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Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses
Gao, Ya-Nan1,2; Pei, Xiao-Yan1,2; Jin, Rong1,2; Yin, Chen1,2; Shen, Hui1,2; Sun, Xiu-yuan1,2; Ge, Qing1,2; Zhang, Yu1,2
关键词Thymic involution Thymic emigrant T cell homeostasis Memory T cell Thymectomy Thymic grafting
刊名BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
2014-11-14
DOI10.1016/j.bbrc.2014.10.037
454期:2页:275-281
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]LYMPHOCYTE DEVELOPMENT ; HOMEOSTASIS ; NAIVE ; AGE ; SURVIVAL ; DEFECTS ; INTERLEUKIN-7 ; REPERTOIRE ; CONVERSION ; SELECTION
英文摘要

Thymic involution is evolutionarily conserved and occurs early in life. However, the physiological significance remains elusive of this seemingly detrimental process. The present study investigated the potential impact of altered thymic output on T cell memory using ovalbumin (OVA) expressed by Listeria monocytogenes as a model antigen. Suspension of thymic emigration by thymectomy was shown to lead to a marked increase in the frequency and total number of OVA-specific memory T cells. In contrast, oversupply of thymic emigrants through thymic grafting caused a significant decrease of such cells. When rechallenged with L. monocytogenes expressing OVA, the thymectomized mice mounted a more potent recall response as evidenced by the enlarged population of OVA-specific tetramer(+) cells and the accelerated clearance of the bacteria. Notably, the memory-enhancing effect of thymectomy was abrogated following weekly adoptive transfer of naive T cells. Together, data from the present study indicate that reduced thymic output favors the maintenance of the memory T cell pool. (C) 2014 Elsevier Inc. All rights reserved.

语种英语
WOS记录号WOS:000346955200004
项目编号2011CB946100 ; 31330025 ; B07001
资助机构National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66575
专题北京大学基础医学院_免疫学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Key Lab Med Immunol,Minist Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Mol & Translat Med, Beijing 100083, Peoples R China
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GB/T 7714
Gao, Ya-Nan,Pei, Xiao-Yan,Jin, Rong,et al. Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,454(2):275-281.
APA Gao, Ya-Nan.,Pei, Xiao-Yan.,Jin, Rong.,Yin, Chen.,Shen, Hui.,...&Zhang, Yu.(2014).Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses.BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,454(2),275-281.
MLA Gao, Ya-Nan,et al."Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses".BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 454.2(2014):275-281.
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