北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses
作者: Gao, Ya-Nan1,2; Pei, Xiao-Yan1,2; Jin, Rong1,2; Yin, Chen1,2; Shen, Hui1,2; Sun, Xiu-yuan1,2; Ge, Qing1,2; Zhang, Yu1,2
关键词: Thymic involution ; Thymic emigrant ; T cell homeostasis ; Memory T cell ; Thymectomy ; Thymic grafting
刊名: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
发表日期: 2014-11-14
DOI: 10.1016/j.bbrc.2014.10.037
卷: 454, 期:2, 页:275-281
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Biophysics
研究领域[WOS]: Biochemistry & Molecular Biology ; Biophysics
关键词[WOS]: LYMPHOCYTE DEVELOPMENT ; HOMEOSTASIS ; NAIVE ; AGE ; SURVIVAL ; DEFECTS ; INTERLEUKIN-7 ; REPERTOIRE ; CONVERSION ; SELECTION
英文摘要:

Thymic involution is evolutionarily conserved and occurs early in life. However, the physiological significance remains elusive of this seemingly detrimental process. The present study investigated the potential impact of altered thymic output on T cell memory using ovalbumin (OVA) expressed by Listeria monocytogenes as a model antigen. Suspension of thymic emigration by thymectomy was shown to lead to a marked increase in the frequency and total number of OVA-specific memory T cells. In contrast, oversupply of thymic emigrants through thymic grafting caused a significant decrease of such cells. When rechallenged with L. monocytogenes expressing OVA, the thymectomized mice mounted a more potent recall response as evidenced by the enlarged population of OVA-specific tetramer(+) cells and the accelerated clearance of the bacteria. Notably, the memory-enhancing effect of thymectomy was abrogated following weekly adoptive transfer of naive T cells. Together, data from the present study indicate that reduced thymic output favors the maintenance of the memory T cell pool. (C) 2014 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2011CB946100 ; 31330025 ; B07001
项目资助者: National Basic Research Program of China ; National Natural Sciences Foundation of China ; 111 Project of China
WOS记录号: WOS:000346955200004
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66575
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
1-s2.0-S0006291X1401835X-main.pdf(1317KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Key Lab Med Immunol,Minist Publ Hlth, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Mol & Translat Med, Beijing 100083, Peoples R China

Recommended Citation:
Gao, Ya-Nan,Pei, Xiao-Yan,Jin, Rong,et al. Suspension of thymic emigration promotes the maintenance of antigen-specific memory T cells and the recall responses[J]. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS,2014,454(2):275-281.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Gao, Ya-Nan]'s Articles
[Pei, Xiao-Yan]'s Articles
[Jin, Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Gao, Ya-Nan]‘s Articles
[Pei, Xiao-Yan]‘s Articles
[Jin, Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace