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学科主题基础医学
Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain
Mu, Hong-Na1,2,3; Li, Quan2,3; Pan, Chun-Shui2,3; Liu, Yu-Ying2,3; Yan, Li2,3; Hu, Bai-He2,3; Sun, Kai2,3; Chang, Xin2,3; Zhao, Xin-Rong2,3; Fan, Jing-Yu2,3; Han, Jing-Yan1,2,3
关键词Superoxide anion Liver microcirculatory disturbance Leukocyte adherence Apoptosis Salvia miltiorrhiza
刊名FREE RADICAL BIOLOGY AND MEDICINE
2015-08-01
DOI10.1016/j.freeradbiomed.2015.04.033
85页:237-249
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
资助者Production of New Medicine Program of the Ministry of Science and Technology of China ; Production of New Medicine Program of the Ministry of Science and Technology of China
研究领域[WOS]Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]CARDIAC ISCHEMIA-REPERFUSION ; IN-VITRO ; MICROCIRCULATORY DISTURBANCE ; ISCHEMIA/REPERFUSION INJURY ; NOTOGINSENOSIDE R1 ; CARDIOTONIC PILLS ; OXIDATIVE INJURY ; PHENETHYL ESTER ; SIR2 HOMOLOG ; COMPLEX-II
英文摘要

Sirtuin 3 (Sirt3) plays critical roles in regulating mitochondrial oxidative metabolism. However, whether Sirt3 is involved in liver ischemia and reperfusion (I/R) injury remains elusive. Caffeic acid (CA) is a natural antioxidant derived from Salvia rniltiorrhiza. Whether CA protects against liver I/R injury through regulating Sirt3 and the mitochondrial respiratory chain (MRC) is unclear. This study investigated the effect of CA on liver I/R. injury, microcirculatory disturbance, and potential mechanisms, particularly focusing on Sirt3-dependent MRC. Liver I/R of male Sprague-Dawley rats was established by occlusion of portal area vessels for 30 min followed by 120 min of reperfusion. CA (15 mg/kg/h) was continuously infused via the femoral vein starting 30 min before ischemia. After I/R, Sirt3 expression, and MRC activity decreased, acetylation of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 and succinate dehydrogenase complex, subunit A, flavoprotein variant provoked, and the liver microcirculatory disturbance and injury were observed. Treatment with CA attenuated liver injury, inhibited Sirt3 down expression, and up regulated MRC activity. CA attenuated rat liver rnicrocirculatory disturbance and oxidative injury through regulation of Sirt3 and the rnitochondrial respiratory chain. (C) 2015 Elsevier Inc. All rights reserved.

语种英语
所属项目编号2013ZX09402202
资助者Production of New Medicine Program of the Ministry of Science and Technology of China ; Production of New Medicine Program of the Ministry of Science and Technology of China
WOS记录号WOS:000358198000023
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66577
专题北京大学基础医学院
作者单位1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.State Adm Tradit Chinese Med, Key Lab Stasis & Phlegm, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Mu, Hong-Na,Li, Quan,Pan, Chun-Shui,et al. Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,85:237-249.
APA Mu, Hong-Na.,Li, Quan.,Pan, Chun-Shui.,Liu, Yu-Ying.,Yan, Li.,...&Han, Jing-Yan.(2015).Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain.FREE RADICAL BIOLOGY AND MEDICINE,85,237-249.
MLA Mu, Hong-Na,et al."Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain".FREE RADICAL BIOLOGY AND MEDICINE 85(2015):237-249.
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