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学科主题: 基础医学
题名:
Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain
作者: Mu, Hong-Na1,2,3; Li, Quan2,3; Pan, Chun-Shui2,3; Liu, Yu-Ying2,3; Yan, Li2,3; Hu, Bai-He2,3; Sun, Kai2,3; Chang, Xin2,3; Zhao, Xin-Rong2,3; Fan, Jing-Yu2,3; Han, Jing-Yan1,2,3
关键词: Superoxide anion ; Liver microcirculatory disturbance ; Leukocyte adherence ; Apoptosis ; Salvia miltiorrhiza
刊名: FREE RADICAL BIOLOGY AND MEDICINE
发表日期: 2015-08-01
DOI: 10.1016/j.freeradbiomed.2015.04.033
卷: 85, 页:237-249
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
研究领域[WOS]: Biochemistry & Molecular Biology ; Endocrinology & Metabolism
关键词[WOS]: CARDIAC ISCHEMIA-REPERFUSION ; IN-VITRO ; MICROCIRCULATORY DISTURBANCE ; ISCHEMIA/REPERFUSION INJURY ; NOTOGINSENOSIDE R1 ; CARDIOTONIC PILLS ; OXIDATIVE INJURY ; PHENETHYL ESTER ; SIR2 HOMOLOG ; COMPLEX-II
英文摘要:

Sirtuin 3 (Sirt3) plays critical roles in regulating mitochondrial oxidative metabolism. However, whether Sirt3 is involved in liver ischemia and reperfusion (I/R) injury remains elusive. Caffeic acid (CA) is a natural antioxidant derived from Salvia rniltiorrhiza. Whether CA protects against liver I/R injury through regulating Sirt3 and the mitochondrial respiratory chain (MRC) is unclear. This study investigated the effect of CA on liver I/R. injury, microcirculatory disturbance, and potential mechanisms, particularly focusing on Sirt3-dependent MRC. Liver I/R of male Sprague-Dawley rats was established by occlusion of portal area vessels for 30 min followed by 120 min of reperfusion. CA (15 mg/kg/h) was continuously infused via the femoral vein starting 30 min before ischemia. After I/R, Sirt3 expression, and MRC activity decreased, acetylation of NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 9 and succinate dehydrogenase complex, subunit A, flavoprotein variant provoked, and the liver microcirculatory disturbance and injury were observed. Treatment with CA attenuated liver injury, inhibited Sirt3 down expression, and up regulated MRC activity. CA attenuated rat liver rnicrocirculatory disturbance and oxidative injury through regulation of Sirt3 and the rnitochondrial respiratory chain. (C) 2015 Elsevier Inc. All rights reserved.

语种: 英语
所属项目编号: 2013ZX09402202
项目资助者: Production of New Medicine Program of the Ministry of Science and Technology of China
WOS记录号: WOS:000358198000023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66577
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100871, Peoples R China
3.State Adm Tradit Chinese Med, Key Lab Stasis & Phlegm, Beijing, Peoples R China

Recommended Citation:
Mu, Hong-Na,Li, Quan,Pan, Chun-Shui,et al. Caffeic acid attenuates rat liver reperfusion injury through sirtuin 3-dependent regulation of mitochondrial respiratory chain[J]. FREE RADICAL BIOLOGY AND MEDICINE,2015,85:237-249.
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