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Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)
Zhang, Liang1; Shao, Wan-fang2; Yuan, Li-feng3; Tu, Peng-fei1; Ma, Zhi-zhong4
关键词Immunosenescence Naive T lymphocytes NK cells Interleukin-6 Pu-erh tea Immune function
刊名FOOD CHEMISTRY
2012-12-15
DOI10.1016/j.foodchem.2012.07.033
135期:4页:2222-2228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]MOLECULAR-MECHANISMS ; CANCER PREVENTION ; POLYPHENOLS ; FERMENTATION ; RESTRICTION ; LYMPHOCYTES
英文摘要

Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for infections, cancer and autoimmune conditions in the elderly. Senescence-accelerated mouse (SAM) was used to study the protective effects of Pu-erh tea in the elderly. The senile-prone sub-strain, SAM-P8 mice were administered individually with ripened or crude Pu-erh tea at 125, 250 or 500 mg/kg. The results showed that Pu-erh tea significantly increased the fractions of naive T lymphocytes, CD8(+)CD28(+) T lymphocytes and NK cells in the peripheral blood, but decreased the levels of IL-6 in aged mice. These data suggested that the Pu-erh tea reversed the immunosenescence by restoring the immune deficiency and decreasing pro-inflammatory cytokine. Thus, long term drinking of Pu-erh tea may be beneficial for the aged population in terms of increasing the body′s resistance to infection and cancer. (C) 2012 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000309786400017
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66578
专题北京大学第三临床医学院_麻醉科
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
3.Yunnan Agr Univ, Coll Long Run Pu Erh Tea, Kunming 650201, Yunnan, Peoples R China
4.Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA
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Zhang, Liang,Shao, Wan-fang,Yuan, Li-feng,et al. Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)[J]. FOOD CHEMISTRY,2012,135(4):2222-2228.
APA Zhang, Liang,Shao, Wan-fang,Yuan, Li-feng,Tu, Peng-fei,&Ma, Zhi-zhong.(2012).Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM).FOOD CHEMISTRY,135(4),2222-2228.
MLA Zhang, Liang,et al."Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)".FOOD CHEMISTRY 135.4(2012):2222-2228.
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