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学科主题: 药学
题名:
Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)
作者: Zhang, Liang1; Shao, Wan-fang2; Yuan, Li-feng3; Tu, Peng-fei1; Ma, Zhi-zhong4
关键词: Immunosenescence ; Naive T lymphocytes ; NK cells ; Interleukin-6 ; Pu-erh tea ; Immune function
刊名: FOOD CHEMISTRY
发表日期: 2012-12-15
DOI: 10.1016/j.foodchem.2012.07.033
卷: 135, 期:4, 页:2222-2228
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Applied ; Food Science & Technology ; Nutrition & Dietetics
研究领域[WOS]: Chemistry ; Food Science & Technology ; Nutrition & Dietetics
关键词[WOS]: MOLECULAR-MECHANISMS ; CANCER PREVENTION ; POLYPHENOLS ; FERMENTATION ; RESTRICTION ; LYMPHOCYTES
英文摘要:

Immunosenescence, the progressive decline of adaptive immunity and chronic inflammation with ageing has been demonstrated to be the main factor responsible for infections, cancer and autoimmune conditions in the elderly. Senescence-accelerated mouse (SAM) was used to study the protective effects of Pu-erh tea in the elderly. The senile-prone sub-strain, SAM-P8 mice were administered individually with ripened or crude Pu-erh tea at 125, 250 or 500 mg/kg. The results showed that Pu-erh tea significantly increased the fractions of naive T lymphocytes, CD8(+)CD28(+) T lymphocytes and NK cells in the peripheral blood, but decreased the levels of IL-6 in aged mice. These data suggested that the Pu-erh tea reversed the immunosenescence by restoring the immune deficiency and decreasing pro-inflammatory cytokine. Thus, long term drinking of Pu-erh tea may be beneficial for the aged population in terms of increasing the body′s resistance to infection and cancer. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2007BAD58B04-2
项目资助者: &prime ; National Tea Industrial Science and Technology System&prime ; from Modern Agriculture Industrial Technology System
WOS记录号: WOS:000309786400017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66578
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Beijing 100191, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, Dept Nat Med, Beijing 100191, Peoples R China
3.Yunnan Agr Univ, Coll Long Run Pu Erh Tea, Kunming 650201, Yunnan, Peoples R China
4.Purdue Univ, Dept Biochem, W Lafayette, IN 47907 USA

Recommended Citation:
Zhang, Liang,Shao, Wan-fang,Yuan, Li-feng,et al. Decreasing pro-inflammatory cytokine and reversing the immunosenescence with extracts of Pu-erh tea in senescence accelerated mouse (SAM)[J]. FOOD CHEMISTRY,2012,135(4):2222-2228.
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