IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer
Zhong, X-Y1; Zhang, L-H1; Jia, S-Q1; Shi, T.; Niu, Z-J2; Du, H.3; Zhang, G-G3; Hu, Y.3; Lu, A-P4; Li, J-Y4; Ji, J-F1
关键词Cripto-1 E-cadherin metastasis prognosis stomach neoplasms
刊名HISTOPATHOLOGY
2008-04-01
DOI10.1111/j.1365-2559.2008.02971.x
52期:5页:560-568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Pathology
研究领域[WOS]Cell Biology ; Pathology
关键词[WOS]EPIDERMAL-GROWTH-FACTOR ; MAMMARY-GLAND DEVELOPMENT ; FACTOR-RELATED PROTEINS ; EGF-CFC FAMILY ; COLORECTAL TUMORS ; EPITHELIAL-CELLS ; CARCINOMA-CELLS ; TRANSGENIC MICE ; BETA-CATENIN ; FACTOR-ALPHA
英文摘要

Aims: Cripto-1 may be capable of up-regulating signalling molecules associated with epithelial-to-mesenchymal transition (EMT), an important event characterized by loss of E-cadherin during malignant tumour progression and metastasis. The aim was to investigate the expression of Cripto-1 and E-cadherin in relation to clinicopathological features and patient prognosis of gastric cancer.

Methods and results: The expression of Cripto-1 and E-cadherin was studied by immunohistochemistry in 118 gastric cancer cases. Up-regulated Cripto-1 (CR+) was found in 54% (64/118) of cases, whereas down-regulated E-cadherin (E-cad-) was found in 70% (83/118) of cases. Either CR+ or E-cad- was associated with lymph node metastasis, liver metastasis and late TNM stage (P < 0.05). Patients with either CR- or E-cad+ showed higher 5-year survival rates than those with CR+ or E-cad- (P = 0.0012 and P = 0.0017, respectively). When combined, evaluation of these two proteins, simultaneous CR+ and E-cad- (CR+/E-cad-) in cancer was strongly associated with the above three aggressive clinicopathological features (P < 0.001) and indicated the worst patient survival (P = 0.0001). Multivariate analysis revealed that CR+/E-cad- was an independent prognostic factor in gastric cancer.

Conclusions: Combined analysis of Cripto-1 and E-cadherin has significant value in evaluating the metastatic potential of gastric cancer and predicting patient prognosis.

语种英语
WOS记录号WOS:000254414700003
引用统计
被引频次:52[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66582
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_标本库
作者单位1.Peking Univ, Beijing Canc Hosp, Sch Oncol,Inst Canc Res, Dept Surg, Beijing 100036, Peoples R China
2.Shandong Univ, Qilu Hosp, Dept Gen Surg, Jinan, Shandong Prov, Peoples R China
3.Peking Univ, Beijing Canc Hosp, Sch Oncol,Inst Canc Res, Tissue Bank, Beijing 100036, Peoples R China
4.Peking Univ, Beijing Canc Hosp, Sch Oncol,Inst Canc Res, Dept Pathol, Beijing 100036, Peoples R China
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GB/T 7714
Zhong, X-Y,Zhang, L-H,Jia, S-Q,et al. Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer[J]. HISTOPATHOLOGY,2008,52(5):560-568.
APA Zhong, X-Y.,Zhang, L-H.,Jia, S-Q.,Shi, T..,Niu, Z-J.,...&Ji, J-F.(2008).Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer.HISTOPATHOLOGY,52(5),560-568.
MLA Zhong, X-Y,et al."Positive association of up-regulated Cripto-1 and down-regulated E-cadherin with tumour progression and poor prognosis in gastric cancer".HISTOPATHOLOGY 52.5(2008):560-568.
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