IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population
Chen, Xiangmei1,2; Zhang, Ling3; Chang, Yibin1,2; Shen, Tao1,2; Wang, Ling1,2; Zhuang, Hui1,2; Lu, Fengmin1,2
关键词Hepatitis B virus Hepatocellular carcinoma Polymorphism Tumor necrosis factor-alpha
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
2011-07-01
DOI10.5301/JBM.2011.8580
26期:3页:181-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]HEPATITIS-B-VIRUS ; NECROSIS-FACTOR-ALPHA ; RISK ; INFECTION ; PROMOTER ; CYTOKINE ; LIVER ; CANCER ; CLEARANCE ; DISEASE
英文摘要

The single nucleotide polymorphisms (SNPs) within the tumor necrosis factor-alpha (TNF-alpha) gene promoter region have been reported to be associated with susceptibility to various types of cancers. A case-control study (126 hepatocellular carcinoma [HCC] patients and 126 normal controls) was conducted to elucidate their possible association with the risk of hepatitis B virus (HBV)-related HCC in a Han Chinese population. TNF-alpha polymorphisms -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped by polymerase chain reaction (PCR) and direct DNA sequencing. Disease associations were analyzed by the chi-square test or Fisher′s exact test. When analyzed by overall groups, no significant differences in genotype and allele distributions were observed between the control and cases. However, stratified analysis according to sex showed that the frequency of the homozygous C allele of the -857 polymorphism was lower in female cases than in female controls (62.9% vs. 88.9%, p = 0.026). In addition, further haplotype analysis revealed that the TCCGA (-1031/-863/-857/-308/-238) was more frequent in controls than cases (p = 0.018; odds ratio = 0.266; 95% confidence interval, 0.083-0.857). These results indicated that the TNF-alpha-857C/T polymorphism may modify HBV-related HCC risk among women, and the haplotype TCCGA (-1031/-863/-857/-308/-238) may account for a decreased susceptibility to HCC development in the Han Chinese population. Additional studies in patients with different ethnic backgrounds are needed to validate these finding and to further explore the genetic pathogenesis of HBV-related HCC.

语种英语
WOS记录号WOS:000297972200006
项目编号2009ZX10004-903
资助机构National S &amp ; T Major Project for Infectious Diseases Control
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66583
专题北京大学基础医学院_病原生物学系
北京大学基础医学院
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Henan Canc Hosp, Dept Hepatobiliary Pancreat Surg, Zhengzhou, Peoples R China
推荐引用方式
GB/T 7714
Chen, Xiangmei,Zhang, Ling,Chang, Yibin,et al. Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2011,26(3):181-187.
APA Chen, Xiangmei.,Zhang, Ling.,Chang, Yibin.,Shen, Tao.,Wang, Ling.,...&Lu, Fengmin.(2011).Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,26(3),181-187.
MLA Chen, Xiangmei,et al."Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 26.3(2011):181-187.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Chen, Xiangmei]的文章
[Zhang, Ling]的文章
[Chang, Yibin]的文章
百度学术
百度学术中相似的文章
[Chen, Xiangmei]的文章
[Zhang, Ling]的文章
[Chang, Yibin]的文章
必应学术
必应学术中相似的文章
[Chen, Xiangmei]的文章
[Zhang, Ling]的文章
[Chang, Yibin]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。