IR@PKUHSC  > 北京大学基础医学院  > 病原生物学系
学科主题基础医学
Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population
Chen, Xiangmei1,2; Zhang, Ling3; Chang, Yibin1,2; Shen, Tao1,2; Wang, Ling1,2; Zhuang, Hui1,2; Lu, Fengmin1,2
关键词Hepatitis B virus Hepatocellular carcinoma Polymorphism Tumor necrosis factor-alpha
刊名INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS
2011-07-01
DOI10.5301/JBM.2011.8580
26期:3页:181-187
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Oncology
资助者National S &amp ; T Major Project for Infectious Diseases Control ; National S &amp ; T Major Project for Infectious Diseases Control
研究领域[WOS]Biotechnology & Applied Microbiology ; Oncology
关键词[WOS]HEPATITIS-B-VIRUS ; NECROSIS-FACTOR-ALPHA ; RISK ; INFECTION ; PROMOTER ; CYTOKINE ; LIVER ; CANCER ; CLEARANCE ; DISEASE
英文摘要

The single nucleotide polymorphisms (SNPs) within the tumor necrosis factor-alpha (TNF-alpha) gene promoter region have been reported to be associated with susceptibility to various types of cancers. A case-control study (126 hepatocellular carcinoma [HCC] patients and 126 normal controls) was conducted to elucidate their possible association with the risk of hepatitis B virus (HBV)-related HCC in a Han Chinese population. TNF-alpha polymorphisms -1031T/C, -863C/A, -857C/T, -308G/A, and -238G/A were genotyped by polymerase chain reaction (PCR) and direct DNA sequencing. Disease associations were analyzed by the chi-square test or Fisher′s exact test. When analyzed by overall groups, no significant differences in genotype and allele distributions were observed between the control and cases. However, stratified analysis according to sex showed that the frequency of the homozygous C allele of the -857 polymorphism was lower in female cases than in female controls (62.9% vs. 88.9%, p = 0.026). In addition, further haplotype analysis revealed that the TCCGA (-1031/-863/-857/-308/-238) was more frequent in controls than cases (p = 0.018; odds ratio = 0.266; 95% confidence interval, 0.083-0.857). These results indicated that the TNF-alpha-857C/T polymorphism may modify HBV-related HCC risk among women, and the haplotype TCCGA (-1031/-863/-857/-308/-238) may account for a decreased susceptibility to HCC development in the Han Chinese population. Additional studies in patients with different ethnic backgrounds are needed to validate these finding and to further explore the genetic pathogenesis of HBV-related HCC.

语种英语
所属项目编号2009ZX10004-903
资助者National S &amp ; T Major Project for Infectious Diseases Control ; National S &amp ; T Major Project for Infectious Diseases Control
WOS记录号WOS:000297972200006
Citation statistics
Cited Times:17[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66583
Collection北京大学基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Ctr Infect Dis, Beijing 100191, Peoples R China
3.Henan Canc Hosp, Dept Hepatobiliary Pancreat Surg, Zhengzhou, Peoples R China
Recommended Citation
GB/T 7714
Chen, Xiangmei,Zhang, Ling,Chang, Yibin,et al. Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,2011,26(3):181-187.
APA Chen, Xiangmei.,Zhang, Ling.,Chang, Yibin.,Shen, Tao.,Wang, Ling.,...&Lu, Fengmin.(2011).Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population.INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS,26(3),181-187.
MLA Chen, Xiangmei,et al."Association of TNF-alpha genetic polymorphisms with hepatocellular carcinoma susceptibility: a case-control study in a Han Chinese population".INTERNATIONAL JOURNAL OF BIOLOGICAL MARKERS 26.3(2011):181-187.
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