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学科主题: 临床医学
题名:
Embryo Manipulation and Imprinting
作者: Marchesi, Dennis E.2; Qiao, Jie1; Feng, Huai L.1,3,4,5
关键词: PGD/PGS ; ICSI ; oocyte/embryo culture ; IVF safety ; imprinting diseases
刊名: SEMINARS IN REPRODUCTIVE MEDICINE
发表日期: 2012-08-01
DOI: 10.1055/s-0032-1320013
卷: 30, 期:4, 页:323-333
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: ASSISTED REPRODUCTIVE TECHNOLOGY ; INTRACYTOPLASMIC SPERM INJECTION ; IN-VITRO FERTILIZATION ; PREIMPLANTATION GENETIC DIAGNOSIS ; RANDOMIZED CONTROLLED-TRIAL ; EARLY MAMMALIAN DEVELOPMENT ; DNA METHYLATION PATTERN ; CLEAVAGE-STAGE EMBRYOS ; HUMAN CUMULUS CELLS ; LONG-TERM HEALTH
英文摘要:

As the use of assisted reproductive technologies (ART) continues to rise worldwide, it remains of the upmost importance to maintain the safety of those techniques used in ART. Many of these practices are unique to this discipline; as such, it becomes difficult to assess the true risks that the potential offspring may be subjected to under this type of treatment. Removal of oocytes from a woman′s body during an in vitro fertilization (IVF) cycle offers an increased opportunity for routine cellular processes to go awry. Specifically, epigenetic modifications and imprinting diseases are rare among the general population; however, although their incidence among IVF-conceived children is also rare, their frequency in this population remains elevated compared with universal rates. Recent investigations have directly attributed their occurrences to the use of ART and IVF to achieve a successful pregnancy. This review discusses the major cellular manipulations of a typical IVF cycle to assess the potential risks versus the reported risks. These manipulations include preimplantation genetic diagnosis and screening, intracytoplasmic sperm injection, ooplasmic transfer, embryo culture, in vitro maturation, and cryopreservation. Oocyte and embryo handling is a delicate part of the IVF process that continues to improve. The safety of those potential improvements is also discussed.

语种: 英语
所属项目编号: C120205
项目资助者: Overseas Outstanding Young Scientist Project
WOS记录号: WOS:000305755300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66589
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.N Shore Univ Hosp LIJ Hlth Syst, Dept Obstet & Gynecol, Manhasset, NY USA
3.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Lab Med, Flushing, NY USA
4.Univ Texas SW Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX 75390 USA
5.Reprobiotech, NHP, New York, NY USA

Recommended Citation:
Marchesi, Dennis E.,Qiao, Jie,Feng, Huai L.. Embryo Manipulation and Imprinting[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2012,30(4):323-333.
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