IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Embryo Manipulation and Imprinting
Marchesi, Dennis E.2; Qiao, Jie1; Feng, Huai L.1,3,4,5
关键词PGD/PGS ICSI oocyte/embryo culture IVF safety imprinting diseases
刊名SEMINARS IN REPRODUCTIVE MEDICINE
2012-08-01
DOI10.1055/s-0032-1320013
30期:4页:323-333
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]ASSISTED REPRODUCTIVE TECHNOLOGY ; INTRACYTOPLASMIC SPERM INJECTION ; IN-VITRO FERTILIZATION ; PREIMPLANTATION GENETIC DIAGNOSIS ; RANDOMIZED CONTROLLED-TRIAL ; EARLY MAMMALIAN DEVELOPMENT ; DNA METHYLATION PATTERN ; CLEAVAGE-STAGE EMBRYOS ; HUMAN CUMULUS CELLS ; LONG-TERM HEALTH
英文摘要

As the use of assisted reproductive technologies (ART) continues to rise worldwide, it remains of the upmost importance to maintain the safety of those techniques used in ART. Many of these practices are unique to this discipline; as such, it becomes difficult to assess the true risks that the potential offspring may be subjected to under this type of treatment. Removal of oocytes from a woman′s body during an in vitro fertilization (IVF) cycle offers an increased opportunity for routine cellular processes to go awry. Specifically, epigenetic modifications and imprinting diseases are rare among the general population; however, although their incidence among IVF-conceived children is also rare, their frequency in this population remains elevated compared with universal rates. Recent investigations have directly attributed their occurrences to the use of ART and IVF to achieve a successful pregnancy. This review discusses the major cellular manipulations of a typical IVF cycle to assess the potential risks versus the reported risks. These manipulations include preimplantation genetic diagnosis and screening, intracytoplasmic sperm injection, ooplasmic transfer, embryo culture, in vitro maturation, and cryopreservation. Oocyte and embryo handling is a delicate part of the IVF process that continues to improve. The safety of those potential improvements is also discussed.

语种英语
WOS记录号WOS:000305755300008
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66589
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位1.Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing 100191, Peoples R China
2.N Shore Univ Hosp LIJ Hlth Syst, Dept Obstet & Gynecol, Manhasset, NY USA
3.Cornell Univ, Weill Med Coll, New York Hosp Queens, Dept Lab Med, Flushing, NY USA
4.Univ Texas SW Med Ctr Dallas, Dept Obstet & Gynecol, Dallas, TX 75390 USA
5.Reprobiotech, NHP, New York, NY USA
推荐引用方式
GB/T 7714
Marchesi, Dennis E.,Qiao, Jie,Feng, Huai L.. Embryo Manipulation and Imprinting[J]. SEMINARS IN REPRODUCTIVE MEDICINE,2012,30(4):323-333.
APA Marchesi, Dennis E.,Qiao, Jie,&Feng, Huai L..(2012).Embryo Manipulation and Imprinting.SEMINARS IN REPRODUCTIVE MEDICINE,30(4),323-333.
MLA Marchesi, Dennis E.,et al."Embryo Manipulation and Imprinting".SEMINARS IN REPRODUCTIVE MEDICINE 30.4(2012):323-333.
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