|Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease|
|Yu Jie1,2,3; Han Jiangli1,2,3; Mao Jieming1,2,3; Guo Lijun1,2,3; Gao Wei1,2,3|
|关键词||serum uric acid obstructive coronary artery disease Syntax score|
|刊名||CHINESE MEDICAL JOURNAL|
|WOS标题词||Science & Technology|
|类目[WOS]||Medicine, General & Internal|
|研究领域[WOS]||General & Internal Medicine|
|关键词[WOS]||PROSPECTIVE OBSERVATIONAL COHORT ; SYNTAX SCORE ; CARDIOVASCULAR-DISEASE ; INDEPENDENT PREDICTOR ; HEART-DISEASE ; RISK-FACTOR ; ALL-CAUSE ; ENDOTHELIAL DYSFUNCTION ; CLINICAL-OUTCOMES ; MORTALITY|
Background Many studies have shown that the serum uric acid (SUA) level is one of the cardiovascular risk factors. The aim of the study is to evaluate the relationship between SUA levels and the severity of coronary artery disease (CAD) assessed by angiography and the Syntax score in patients with obstructive CAD.
Methods Participants who visited our hospital for a coronary angiography, from December 2007 to September 2012, were eligible for this analysis. SUA and other blood parameters after at least 12-hour fast were determined. First, the patients were divided into tertiles according to their Syntax scores (low Syntax score group: Syntax score <= 10.0; moderate Syntax score group: 10.0
Results A total of 347 patients were registered for the study. The SUA levels in the high Syntax score group were significantly higher than that of the moderate Syntax score group and the low Syntax score group ((392.3 +/- 81.6) mu mol/L vs. (329.9 +/- 71.0) mu mol/L, P<0.001; (392.3 +/- 81.6) mu mol/L vs. (311.4 +/- 64.7) mu mol/L, P <0.001). The SUA level was positively correlated not only with the Syntax score (r=0.421, P <0.001; 95% Cl: 0.333-0.512), but also with the number of diseased vessels (r=0.298, P <0.001; 95% Cl: 0.194-0.396). After multiple linear regression analysis, SUA levels were identified to be independently correlated with a high Syntax score (B=0.033, 95% Cl 0.023-0.042, P <0.001). Compared with the normal SUA subgroup, the high SUA subgroup tended to have a higher Syntax score (19.9 +/- 8.7 vs. 13.6 +/- 7.5, P <0.001) and more multi-vessel disease (70.8% vs. 46.6%, P <0.001). Follow-up data showed a higher incidence of MACE in the high SUA subgroup (20.8% vs. 6.0%, P <0.001). Binary Logistic regression analysis indicated that the elevated SUA can predict the long-term prognosis of patients with obstructive CAD (OR=2.968, 95% Cl 1.256-7.011, P=0.013). Kaplan-Meier analysis showed a significantly lower event-free survival rate in patients with high SUA levels than in the normal SUA subgroup (79.2% vs. 94.0%, Log rank=17.645, P<0.001).
Conclusions SUA levels were independently associated with the severity of CAD in patients with obstructive CAD. An elevated SUA is associated with cardiovascular events and may be useful as a biomarker of the severity of CAD.
|作者单位||1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China|
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
|Yu Jie,Han Jiangli,Mao Jieming,et al. Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease[J]. CHINESE MEDICAL JOURNAL,2014,127(6):1039-1045.|
|APA||Yu Jie,Han Jiangli,Mao Jieming,Guo Lijun,&Gao Wei.(2014).Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease.CHINESE MEDICAL JOURNAL,127(6),1039-1045.|
|MLA||Yu Jie,et al."Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease".CHINESE MEDICAL JOURNAL 127.6(2014):1039-1045.|