IR@PKUHSC  > 北京大学第三临床医学院  > 心血管内科
学科主题临床医学
Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease
Yu Jie1,2,3; Han Jiangli1,2,3; Mao Jieming1,2,3; Guo Lijun1,2,3; Gao Wei1,2,3
关键词serum uric acid obstructive coronary artery disease Syntax score
刊名CHINESE MEDICAL JOURNAL
2014-03-20
DOI10.3760/cma.j.issn.0366-6999.20133024
127期:6页:1039-1045
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]PROSPECTIVE OBSERVATIONAL COHORT ; SYNTAX SCORE ; CARDIOVASCULAR-DISEASE ; INDEPENDENT PREDICTOR ; HEART-DISEASE ; RISK-FACTOR ; ALL-CAUSE ; ENDOTHELIAL DYSFUNCTION ; CLINICAL-OUTCOMES ; MORTALITY
英文摘要

Background Many studies have shown that the serum uric acid (SUA) level is one of the cardiovascular risk factors. The aim of the study is to evaluate the relationship between SUA levels and the severity of coronary artery disease (CAD) assessed by angiography and the Syntax score in patients with obstructive CAD.

Methods Participants who visited our hospital for a coronary angiography, from December 2007 to September 2012, were eligible for this analysis. SUA and other blood parameters after at least 12-hour fast were determined. First, the patients were divided into tertiles according to their Syntax scores (low Syntax score group: Syntax score <= 10.0; moderate Syntax score group: 10.0 18.0). Second, to clarify the association between SUA levels and major adverse cardiovascular events (MACEs), all patients were divided into two subgroups on the basis of SUA levels. The cutoff value of SUA was defined by diagnostic criteria of hyperuricemia. Patients were separated into normal SUA group (n=251, with SUA <416 mu mol/L for men and SUA <357 mu mol/L for women) and high SUA group (n=96, with SUA >= 416 mu mol/L for men and SUA >= 357 mu mol/L for women). All participants were followed for a mean of 22.0 months (1-75 months, interquartile range: 28 months) for major adverse cardiovascular events (MACEs), including all-cause death, recurrent nonfatal myocardial infarction (re-MI) and recurrent percutaneous coronary intervention (re-PC!).

Results A total of 347 patients were registered for the study. The SUA levels in the high Syntax score group were significantly higher than that of the moderate Syntax score group and the low Syntax score group ((392.3 +/- 81.6) mu mol/L vs. (329.9 +/- 71.0) mu mol/L, P<0.001; (392.3 +/- 81.6) mu mol/L vs. (311.4 +/- 64.7) mu mol/L, P <0.001). The SUA level was positively correlated not only with the Syntax score (r=0.421, P <0.001; 95% Cl: 0.333-0.512), but also with the number of diseased vessels (r=0.298, P <0.001; 95% Cl: 0.194-0.396). After multiple linear regression analysis, SUA levels were identified to be independently correlated with a high Syntax score (B=0.033, 95% Cl 0.023-0.042, P <0.001). Compared with the normal SUA subgroup, the high SUA subgroup tended to have a higher Syntax score (19.9 +/- 8.7 vs. 13.6 +/- 7.5, P <0.001) and more multi-vessel disease (70.8% vs. 46.6%, P <0.001). Follow-up data showed a higher incidence of MACE in the high SUA subgroup (20.8% vs. 6.0%, P <0.001). Binary Logistic regression analysis indicated that the elevated SUA can predict the long-term prognosis of patients with obstructive CAD (OR=2.968, 95% Cl 1.256-7.011, P=0.013). Kaplan-Meier analysis showed a significantly lower event-free survival rate in patients with high SUA levels than in the normal SUA subgroup (79.2% vs. 94.0%, Log rank=17.645, P<0.001).

Conclusions SUA levels were independently associated with the severity of CAD in patients with obstructive CAD. An elevated SUA is associated with cardiovascular events and may be useful as a biomarker of the severity of CAD.

语种英语
WOS记录号WOS:000334325100008
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66590
Collection北京大学第三临床医学院_心血管内科
作者单位1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100191, Peoples R China
2.Peking Univ, Hosp 3, Dept Cardiol, Beijing 100191, Peoples R China
3.Minist Hlth, Key Lab Cardiovasc Mol Biol & Regulatory Peptides, Beijing 100191, Peoples R China
Recommended Citation
GB/T 7714
Yu Jie,Han Jiangli,Mao Jieming,et al. Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease[J]. CHINESE MEDICAL JOURNAL,2014,127(6):1039-1045.
APA Yu Jie,Han Jiangli,Mao Jieming,Guo Lijun,&Gao Wei.(2014).Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease.CHINESE MEDICAL JOURNAL,127(6),1039-1045.
MLA Yu Jie,et al."Association between serum uric acid level and the severity of coronary artery disease in patients with obstructive coronary artery disease".CHINESE MEDICAL JOURNAL 127.6(2014):1039-1045.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Yu Jie]'s Articles
[Han Jiangli]'s Articles
[Mao Jieming]'s Articles
百度学术
百度学术Similar articles in
[Yu Jie]'s Articles
[Han Jiangli]'s Articles
[Mao Jieming]'s Articles
必应学术
必应学术Similar articles in
[Yu Jie]'s Articles
[Han Jiangli]'s Articles
[Mao Jieming]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.