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学科主题: 临床医学
题名:
Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients
作者: Zhai, Guojun1; Yang, Hua2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5; Li, Xuan1
关键词: LAPTM4B ; Gene polymorphism ; Susceptibility ; HCC
刊名: MEDICAL ONCOLOGY
发表日期: 2012-12-01
DOI: 10.1007/s12032-011-0139-y
卷: 29, 期:4, 页:2744-2749
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: INDEPENDENT PROGNOSTIC MARKER ; CERVICAL-CARCINOMA ; GENE POLYMORPHISM ; OVEREXPRESSION ; CANCER ; SUSCEPTIBILITY ; PROGRESSION ; EXPRESSION ; SURVIVAL ; PLAY
英文摘要:

Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality in many countries. Evaluation of new susceptibility risk factors is therefore warranted in order to explore means to improve the survival rate. Here, we report on a novel HCC-related gene known as lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in allele *2 in exon 1 of LAPTM4B. In this study, we aimed to investigate the relationship between LAPTM4B allelic variation and HCC susceptibility. The LAPTM4B genotype was analyzed in the blood samples from 102 HCC patients and 135 healthy individuals by PCR. The genotypic distribution of LAPTM4B was analyzed using the chi-squared test. The frequencies of allele *2 were 38.24 and 24.07% in the HCC group and control group, respectively, representing a significant difference between these two groups (P < 0.001). Thus, allele *2 of LAPTM4B appears to be associated with genetic susceptibility of HCC and may therefore be considered as a risk factor.

语种: 英语
WOS记录号: WOS:000309711600066
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66592
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92354 USA
2.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China

Recommended Citation:
Zhai, Guojun,Yang, Hua,Ji, Xiaoxu,et al. Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients[J]. MEDICAL ONCOLOGY,2012,29(4):2744-2749.
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