IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients
Zhai, Guojun1; Yang, Hua2; Ji, Xiaoxu3; Xiong, Fuxia4; Su, Jing5; McNutt, Michael A.5; Li, Xuan1
关键词LAPTM4B Gene polymorphism Susceptibility HCC
刊名MEDICAL ONCOLOGY
2012-12-01
DOI10.1007/s12032-011-0139-y
29期:4页:2744-2749
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]INDEPENDENT PROGNOSTIC MARKER ; CERVICAL-CARCINOMA ; GENE POLYMORPHISM ; OVEREXPRESSION ; CANCER ; SUSCEPTIBILITY ; PROGRESSION ; EXPRESSION ; SURVIVAL ; PLAY
英文摘要

Hepatocellular carcinoma (HCC) is the leading cause of cancer mortality in many countries. Evaluation of new susceptibility risk factors is therefore warranted in order to explore means to improve the survival rate. Here, we report on a novel HCC-related gene known as lysosomal protein transmembrane 4 beta (LAPTM4B) that has two alleles designated LAPTM4B*1 and LAPTM4B*2. Allele *1 differs from allele *2 in that it contains one copy of a 19-bp sequence, whereas this sequence is duplicated in allele *2 in exon 1 of LAPTM4B. In this study, we aimed to investigate the relationship between LAPTM4B allelic variation and HCC susceptibility. The LAPTM4B genotype was analyzed in the blood samples from 102 HCC patients and 135 healthy individuals by PCR. The genotypic distribution of LAPTM4B was analyzed using the chi-squared test. The frequencies of allele *2 were 38.24 and 24.07% in the HCC group and control group, respectively, representing a significant difference between these two groups (P < 0.001). Thus, allele *2 of LAPTM4B appears to be associated with genetic susceptibility of HCC and may therefore be considered as a risk factor.

语种英语
WOS记录号WOS:000309711600066
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66592
专题北京大学第三临床医学院
北京大学基础医学院
作者单位1.Loma Linda Univ, Dept Pharmacol, Loma Linda, CA 92354 USA
2.Peking Univ, Hosp 3, Dept Intervent Radiol & Vasc Surg, Beijing 100191, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Dept Cell Biol, Beijing 100191, Peoples R China
4.Peking Univ, Hosp 3, Dept Gen Surg, Beijing 100191, Peoples R China
5.Peking Univ, Sch Basic Med Sci, Dept Pathol, Beijing 100191, Peoples R China
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GB/T 7714
Zhai, Guojun,Yang, Hua,Ji, Xiaoxu,et al. Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients[J]. MEDICAL ONCOLOGY,2012,29(4):2744-2749.
APA Zhai, Guojun.,Yang, Hua.,Ji, Xiaoxu.,Xiong, Fuxia.,Su, Jing.,...&Li, Xuan.(2012).Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients.MEDICAL ONCOLOGY,29(4),2744-2749.
MLA Zhai, Guojun,et al."Correlation of LAPTM4B polymorphisms with hepatocellular carcinoma in Chinese patients".MEDICAL ONCOLOGY 29.4(2012):2744-2749.
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