IR@PKUHSC  > 基础医学院  > 病原生物学系
学科主题基础医学
Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China
Geng, J.1,2; Wang, L.1; Wang, X.1; Fu, H.1; Bu, Q.1; Liu, P.1; Zhu, Y.1; Wang, M.2; Sui, Y.2; Zhuang, H.1
关键词anti-hepatitis E virus genotype hepatitis E virus zoonotic transmission
刊名JOURNAL OF VIRAL HEPATITIS
2011-10-01
DOI10.1111/j.1365-2893.2011.01472.x
18期:10页:E583-E590
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
资助者863 National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; 863 National High Technology Research and Development Program of China ; National Natural Science Foundation of China
研究领域[WOS]Gastroenterology & Hepatology ; Infectious Diseases ; Virology
关键词[WOS]LIVER-TRANSPLANT RECIPIENTS ; CROSS-SPECIES INFECTION ; EASTERN CHINA ; DOMESTIC-ANIMALS ; ENDEMIC AREA ; PREVALENCE ; HEV ; GENOME ; JAPAN ; SEROPREVALENCE
英文摘要

The aim of this study was to further investigate the prevalence of infection and genotype of hepatitis E virus (HEV) among different species of animals, people whose works are related to pigs and the general population in the suburb of Beijing, China. Serum and faecal samples were collected from 10 animal species and humans. Anti-HEV was detected by enzyme immunoassays (EIA); HEV RNA was amplified by reverse transcription-nested polymerase chain reaction (RT-nPCR) method. PCR products were cloned and sequenced. The isolated swine HEV sequences were analysed phylogenetically. The positive rates of serum anti-HEV in swine, cattle, milk cow, horse, sheep, donkey, dog, duck, chicken, pig farm workers and slaughterhouse workers, and general population were 81.17% (802/988), 25.29% (66/261), 14.87% (40/269), 14.29% (40/280), 9.30% (53/514), 0 (0/25), 0 (0/20), 2.53% (8/316), 3.03% (7/231), 58.73% (37/63), 35.87% (66/184) and 20.06% (538/2682), respectively. The anti-HEV prevalence in adult swine (6 months) and younger swine (<= 3 months) was 91.49% (591/646) and 61.7% (211/342), respectively. The positive rate of HEV RNA in young swine faeces was 47.94% (93/194). All 93 isolates from the younger swine shared 87.8100% nucleotide homology with each other and had identities of 75.6-78.9%, 73.9-76.1%, 76.4-80.6% and 83.1-95.0% with the corresponding regions of genotypes 1-4 HEV, respectively. Phylogenetic analysis showed that all HEV isolates belong to genotype 4, subgenotype 4d. These results suggest a potential risk of zoonotic transmission of HEV from younger swine to farmers who rear pigs.

语种英语
所属项目编号2006A02Z453 ; 30570063
资助者863 National High Technology Research and Development Program of China ; National Natural Science Foundation of China ; 863 National High Technology Research and Development Program of China ; National Natural Science Foundation of China
WOS记录号WOS:000295091500024
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66595
专题基础医学院_病原生物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Microbiol, Beijing 100191, Peoples R China
2.81st Hosp PLA, Inst Hepatol, Nanjing, Peoples R China
推荐引用方式
GB/T 7714
Geng, J.,Wang, L.,Wang, X.,et al. Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China[J]. JOURNAL OF VIRAL HEPATITIS,2011,18(10):E583-E590.
APA Geng, J..,Wang, L..,Wang, X..,Fu, H..,Bu, Q..,...&Zhuang, H..(2011).Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China.JOURNAL OF VIRAL HEPATITIS,18(10),E583-E590.
MLA Geng, J.,et al."Potential risk of zoonotic transmission from young swine to human: seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China".JOURNAL OF VIRAL HEPATITIS 18.10(2011):E583-E590.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Potential risk of zo(170KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Geng, J.]的文章
[Wang, L.]的文章
[Wang, X.]的文章
百度学术
百度学术中相似的文章
[Geng, J.]的文章
[Wang, L.]的文章
[Wang, X.]的文章
必应学术
必应学术中相似的文章
[Geng, J.]的文章
[Wang, L.]的文章
[Wang, X.]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Potential risk of zoonotic transmission from young swine to human seroepidemiological and genetic characterization of hepatitis E virus in human and various animals in Beijing, China.pdf
格式: Adobe PDF
此文件暂不支持浏览
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。