|Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk|
|Xu, Hong1,2,4; Huang, Xiaoyan1,2,5; Riserus, Ulf6; Krishnamurthy, Vidya M.1,2; Cederholm, Tommy6; Arnlov, Johan7,8; Lindholm, Bengt1,2; Sjogren, Per6; Carrero, Juan Jesus1,2,3|
|刊名||CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY|
|WOS标题词||Science & Technology|
|类目[WOS]||Urology & Nephrology|
|研究领域[WOS]||Urology & Nephrology|
|关键词[WOS]||CHRONIC-RENAL-FAILURE ; GLOMERULAR-FILTRATION-RATE ; ALL-CAUSE MORTALITY ; C-REACTIVE PROTEIN ; CARDIOVASCULAR-DISEASE ; NITROGEN-EXCRETION ; FERMENTABLE CARBOHYDRATE ; DIABETIC-PATIENTS ; SERUM CREATININE ; CYSTATIN-C|
Background and objectives In the United States population, high dietary fiber intake has been associated with a lower risk of inflammation and mortality in individuals with kidney dysfunction. This study aimed to expand such findings to a Northern European population.
Design, setting, participants, & measurements Dietary fiber intake was calculated from 7-day dietary records in 1110 participants aged 70-71 years from the Uppsala Longitudinal Study of Adult Men (examinations performed during 1991-1995). Dietary fiber was adjusted for total energy intake by the residual method. Renal function was estimated from the concentration of serum cystatin C, and deaths were registered prospectively during a median follow-up of 10.0 years.
Results Dietary fiber independently and directly associated with eGFR (adjusted difference, 2.6 ml/min per 1.73 m(2) per 10 g/d higher; 95% confidence interval [95% CI], 0.3 to 4.9). The odds of C-reactive protein >3 mg/L were lower (linear trend, P=0.002) with higher fiber quartiles. During follow-up, 300 participants died (incidence rate of 2.87 per 100 person-years at risk). Multiplicative interactions were observed between dietary fiber intake and kidney dysfunction in the prediction of mortality. Higher dietary fiber was associated with lower mortality in unadjusted analysis. These associations were stronger in participants with kidney dysfunction (eGFR<60 ml/min per 1.73 m2) (hazard ratio [HR], 0.58; 95% CI, 0.35 to 0.98) than in those without (HR, 1.30; 95% CI, 0.76 to 2.22; P value for interaction, P=0.04), and were mainly explained by a lower incidence of cancer-related deaths (0.25; 95% CI, 0.10 to 0.65) in individuals with kidney dysfunction versus individuals with an eGFR >= 60 ml/min per 1.73 m(2) (1.61; 95% CI, 0.69 to 3.74; P value for interaction, P=0.01).
Conclusions High dietary fiber was associated with better kidney function and lower inflammation in community-dwelling elderly men from Sweden. High dietary fiber was also associated with lower (cancer) mortality risk, especially in individuals with kidney dysfunction.
|资助机构||Swedish Research Council ; Karolinska Institute ; Baxter Healthcare Corporation|
|作者单位||1.Karolinska Inst, Div Renal Med, SE-14186 Stockholm, Sweden|
2.Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden
3.Karolinska Inst, Ctr Mol Med, SE-14186 Stockholm, Sweden
4.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nephrol, Beijing 100730, Peoples R China
6.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Peoples R China
7.Uppsala Univ, Sect Clin Nutr & Metab, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
8.Uppsala Univ, Sect Geriatr, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
|Xu, Hong,Huang, Xiaoyan,Riserus, Ulf,et al. Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2014,9(12):2104-2110.|
|APA||Xu, Hong.,Huang, Xiaoyan.,Riserus, Ulf.,Krishnamurthy, Vidya M..,Cederholm, Tommy.,...&Carrero, Juan Jesus.(2014).Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk.CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,9(12),2104-2110.|
|MLA||Xu, Hong,et al."Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk".CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 9.12(2014):2104-2110.|