IR@PKUHSC  > 北京大学深圳医院  > 肾内科
学科主题临床医学
Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk
Xu, Hong1,2,4; Huang, Xiaoyan1,2,5; Riserus, Ulf6; Krishnamurthy, Vidya M.1,2; Cederholm, Tommy6; Arnlov, Johan7,8; Lindholm, Bengt1,2; Sjogren, Per6; Carrero, Juan Jesus1,2,3
刊名CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY
2014-12-01
DOI10.2215/CJN.02260314
9期:12页:2104-2110
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]CHRONIC-RENAL-FAILURE ; GLOMERULAR-FILTRATION-RATE ; ALL-CAUSE MORTALITY ; C-REACTIVE PROTEIN ; CARDIOVASCULAR-DISEASE ; NITROGEN-EXCRETION ; FERMENTABLE CARBOHYDRATE ; DIABETIC-PATIENTS ; SERUM CREATININE ; CYSTATIN-C
英文摘要

Background and objectives In the United States population, high dietary fiber intake has been associated with a lower risk of inflammation and mortality in individuals with kidney dysfunction. This study aimed to expand such findings to a Northern European population.

Design, setting, participants, & measurements Dietary fiber intake was calculated from 7-day dietary records in 1110 participants aged 70-71 years from the Uppsala Longitudinal Study of Adult Men (examinations performed during 1991-1995). Dietary fiber was adjusted for total energy intake by the residual method. Renal function was estimated from the concentration of serum cystatin C, and deaths were registered prospectively during a median follow-up of 10.0 years.

Results Dietary fiber independently and directly associated with eGFR (adjusted difference, 2.6 ml/min per 1.73 m(2) per 10 g/d higher; 95% confidence interval [95% CI], 0.3 to 4.9). The odds of C-reactive protein >3 mg/L were lower (linear trend, P=0.002) with higher fiber quartiles. During follow-up, 300 participants died (incidence rate of 2.87 per 100 person-years at risk). Multiplicative interactions were observed between dietary fiber intake and kidney dysfunction in the prediction of mortality. Higher dietary fiber was associated with lower mortality in unadjusted analysis. These associations were stronger in participants with kidney dysfunction (eGFR<60 ml/min per 1.73 m2) (hazard ratio [HR], 0.58; 95% CI, 0.35 to 0.98) than in those without (HR, 1.30; 95% CI, 0.76 to 2.22; P value for interaction, P=0.04), and were mainly explained by a lower incidence of cancer-related deaths (0.25; 95% CI, 0.10 to 0.65) in individuals with kidney dysfunction versus individuals with an eGFR >= 60 ml/min per 1.73 m(2) (1.61; 95% CI, 0.69 to 3.74; P value for interaction, P=0.01).

Conclusions High dietary fiber was associated with better kidney function and lower inflammation in community-dwelling elderly men from Sweden. High dietary fiber was also associated with lower (cancer) mortality risk, especially in individuals with kidney dysfunction.

语种英语
WOS记录号WOS:000345947800014
Citation statistics
Cited Times:19[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66600
Collection北京大学深圳医院_肾内科
作者单位1.Karolinska Inst, Div Renal Med, SE-14186 Stockholm, Sweden
2.Karolinska Inst, Div Baxter Novum, Dept Clin Sci Intervent & Technol, SE-14186 Stockholm, Sweden
3.Karolinska Inst, Ctr Mol Med, SE-14186 Stockholm, Sweden
4.Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
5.Chinese Acad Med Sci, Peking Union Med Coll Hosp, Dept Nephrol, Beijing 100730, Peoples R China
6.Peking Univ, Shenzhen Hosp, Div Nephrol, Shenzhen, Peoples R China
7.Uppsala Univ, Sect Clin Nutr & Metab, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
8.Uppsala Univ, Sect Geriatr, Dept Publ Hlth & Caring Sci, Uppsala, Sweden
Recommended Citation
GB/T 7714
Xu, Hong,Huang, Xiaoyan,Riserus, Ulf,et al. Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk[J]. CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,2014,9(12):2104-2110.
APA Xu, Hong.,Huang, Xiaoyan.,Riserus, Ulf.,Krishnamurthy, Vidya M..,Cederholm, Tommy.,...&Carrero, Juan Jesus.(2014).Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk.CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY,9(12),2104-2110.
MLA Xu, Hong,et al."Dietary Fiber, Kidney Function, Inflammation, and Mortality Risk".CLINICAL JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 9.12(2014):2104-2110.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
谷歌学术
谷歌学术Similar articles in
[Xu, Hong]'s Articles
[Huang, Xiaoyan]'s Articles
[Riserus, Ulf]'s Articles
百度学术
百度学术Similar articles in
[Xu, Hong]'s Articles
[Huang, Xiaoyan]'s Articles
[Riserus, Ulf]'s Articles
必应学术
必应学术Similar articles in
[Xu, Hong]'s Articles
[Huang, Xiaoyan]'s Articles
[Riserus, Ulf]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.