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学科主题: 药物依赖
题名:
L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice
作者: Zhang, Q; Li, JX; Zheng, JW; Liu, RK; Liang, JH
关键词: morphine ; locomotor activity ; behavioral sensitization ; nifedipine ; nimodipine ; verapamil
刊名: EUROPEAN JOURNAL OF PHARMACOLOGY
发表日期: 2003-04-25
DOI: 10.1016/S0014-2999(03)01576-X
卷: 467, 期:1-3, 页:145-150
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: VENTRAL TEGMENTAL AREA ; BEHAVIORAL SENSITIZATION ; LOCOMOTOR-ACTIVITY ; DIHYDROPYRIDINE BINDING ; INDUCED HYPERMOTILITY ; CALCIUM CHANNELS ; RATS ; NIFEDIPINE ; ANALGESIA ; DRUG
英文摘要:

The relationship between opioid actions and L-type Ca2+ channel blockers has been well documented. However, there is no report relevant to L-type Ca2+ channel blockers and morphine sensitization, which is suggested to be an analog of behaviors that are characteristic of drug addiction. We now studied systematically the effects of three L-type Ca2+ channel blockers, nimodipine, nifedipine and verapamil, on morphine-induced locomotor activity, the development and the expression of sensitization to morphine. The results showed that both nimodipine and verapamil attenuated, while nifedipine had only a tendency to decrease morphine-induced locomotor activity. All three drugs inhibited the development of sensitization to morphine. However, none of them showed any effects on the expression of morphine sensitization. These results indicate that blocking L-type Ca2+ channel attenuates the locomotor-stimulating effects of morphine and inhibits the development but not the expression of morphine sensitization. (C) 2003 Elsevier Science B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000182554700020
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66602
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China

Recommended Citation:
Zhang, Q,Li, JX,Zheng, JW,et al. L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2003,467(1-3):145-150.
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