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L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice
Zhang, Q; Li, JX; Zheng, JW; Liu, RK; Liang, JH
关键词morphine locomotor activity behavioral sensitization nifedipine nimodipine verapamil
刊名EUROPEAN JOURNAL OF PHARMACOLOGY
2003-04-25
DOI10.1016/S0014-2999(03)01576-X
467期:1-3页:145-150
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]VENTRAL TEGMENTAL AREA ; BEHAVIORAL SENSITIZATION ; LOCOMOTOR-ACTIVITY ; DIHYDROPYRIDINE BINDING ; INDUCED HYPERMOTILITY ; CALCIUM CHANNELS ; RATS ; NIFEDIPINE ; ANALGESIA ; DRUG
英文摘要

The relationship between opioid actions and L-type Ca2+ channel blockers has been well documented. However, there is no report relevant to L-type Ca2+ channel blockers and morphine sensitization, which is suggested to be an analog of behaviors that are characteristic of drug addiction. We now studied systematically the effects of three L-type Ca2+ channel blockers, nimodipine, nifedipine and verapamil, on morphine-induced locomotor activity, the development and the expression of sensitization to morphine. The results showed that both nimodipine and verapamil attenuated, while nifedipine had only a tendency to decrease morphine-induced locomotor activity. All three drugs inhibited the development of sensitization to morphine. However, none of them showed any effects on the expression of morphine sensitization. These results indicate that blocking L-type Ca2+ channel attenuates the locomotor-stimulating effects of morphine and inhibits the development but not the expression of morphine sensitization. (C) 2003 Elsevier Science B.V. All rights reserved.

语种英语
WOS记录号WOS:000182554700020
引用统计
被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66602
专题中国药物依赖性研究所
作者单位Peking Univ, Natl Inst Drug Dependence, Dept Neuropharmacol, Beijing 100083, Peoples R China
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GB/T 7714
Zhang, Q,Li, JX,Zheng, JW,et al. L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice[J]. EUROPEAN JOURNAL OF PHARMACOLOGY,2003,467(1-3):145-150.
APA Zhang, Q,Li, JX,Zheng, JW,Liu, RK,&Liang, JH.(2003).L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice.EUROPEAN JOURNAL OF PHARMACOLOGY,467(1-3),145-150.
MLA Zhang, Q,et al."L-type Ca2+ channel blockers inhibit the development but not the expression of sensitization to morphine in mice".EUROPEAN JOURNAL OF PHARMACOLOGY 467.1-3(2003):145-150.
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