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学科主题: 基础医学
题名:
IMPROVING EFFECT OF PRETREATMENT WITH YIQIFUMAI ON LPS-INDUCED MICROCIRCULATORY DISTURBANCE IN RAT MESENTERY
作者: Yuan, Qing4; Liu, Yu-Ying3; Sun, Kai3; Chen, Chun-Hua2; Zhou, Chang-Man2; Wang, Chuan-She1,3; Li, Ang4; Zhang, Shu-Wen4; Ye, Zheng-Liang3; Fan, Jing-Yu3; Han, Jing-Yan1,3
关键词: Microcirculatory disturbance ; leukocyte adhesion ; reactive oxygen species ; mast cell degranulation LPS ; Chinese medicine
刊名: SHOCK
发表日期: 2009-09-01
DOI: 10.1097/SHK.0b013e31819c36e8
卷: 32, 期:3, 页:310-316
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Hematology ; Surgery ; Peripheral Vascular Disease
研究领域[WOS]: General & Internal Medicine ; Hematology ; Surgery ; Cardiovascular System & Cardiology
关键词[WOS]: ENDOTHELIAL-CELL-ADHESION ; CHINESE HERBAL MEDICINE ; SEVERE SEPSIS ; SHENGMAI-SAN ; MAST-CELLS ; LIPOPOLYSACCHARIDE ; ENDOTOXEMIA ; INJURY ; BRAIN ; REPERFUSION
英文摘要:

Yiqifumai is a traditional Chinese medicine compound preparation used for the treatment of various vascular diseases in China. However, little is known regarding its role in microcirculation. The present study investigated the effect of pretreatment of Yiqifumai on rat mesentery microcirculatory disturbance induced by LPS. Male Wistar rats were continuously infused with LPS (5 mg kg(-1) h(-1)). The parameters evaluated included diameter of and red blood cell velocity in venules, leukocyte adhesion to venular wall, dihydrorhodamine 123 (DHR) fluorescence in the venular walls, fluorescein isothiocyanate-albumin leakage, and mast cell degranulation, which were observed by an inverted intravital microscope. CD11b/CD18 expression on neutrophils was examined using flow cytometry. In some rats, Yiqifumai (5, 30, or 80 mg kg(-1)) was given in one shot 10 min before LPS infusion. After infusion of LIPS, the number of leukocytes adherent to venular wall, the intensity of DHR fluorescence in the venular walls, albumin leakage from venules, and degranulated mast cells were significantly increased, whereas the red blood cell velocity in venule was decreased. Pretreatment with high-dose Yiqifumai (80 mg kg(-1)) significantly reduced the number of adherent leukocytes, the intensity of DHR fluorescence, degranulation of mast cell, albumin leakage, and the expression of CD11b/CD18, whereas the Yiqifumai of medium dose (30 mg kg(-1)) only inhibited leukocyte adhesion to the venular wall. The results suggested that pretreatment with Yiqifumai attenuated microcirculatory disturbance induced by LIPS. This effect may be associated with Yiqifumai′s inhibition effect on reactive oxygen species production, leukocyte adhesion, and mast cell degranulation.

语种: 英语
项目资助者: Tianjin Tasly Group, Tianjin, China
WOS记录号: WOS:000269226000013
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66606
Appears in Collections:基础医学院_期刊论文

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作者单位: 1.Peking Univ, Sch Basic Med Sci, Dept Integrat Chinese & Western Med, Beijing 100871, Peoples R China
2.Peking Univ, Sch Basic Med Sci, Dept Anat, Beijing 100083, Peoples R China
3.Peking Univ, Hlth Sci Ctr, Tasly Microcirculat Res Ctr, Beijing 100083, Peoples R China
4.Capital Univ Med Sci, Beijing Friendship Hosp Affiliated, Dept Intens Care Unit, Beijing, Peoples R China

Recommended Citation:
Yuan, Qing,Liu, Yu-Ying,Sun, Kai,et al. IMPROVING EFFECT OF PRETREATMENT WITH YIQIFUMAI ON LPS-INDUCED MICROCIRCULATORY DISTURBANCE IN RAT MESENTERY[J]. SHOCK,2009,32(3):310-316.
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