北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 肾脏内科  > 期刊论文
学科主题: 临床医学
题名:
C-reactive protein enhances the respiratory burst of neutrophils-induced by antineutrophil cytoplasmic antibody
作者: Xu, Peng-cheng1,2,3,4,5; Hao, Jian1,2,3,4; Yang, Xiao-wei1,2,3,4; Chang, Dong-yuan1,2,3,4; Chen, Min1,2,3,4; Zhao, Ming-hui1,2,3,4
关键词: C-reactive protein ; Neutrophil ; Anti-neutrophil cytoplasmic antibody ; Vasculitis
刊名: MOLECULAR IMMUNOLOGY
发表日期: 2012-10-01
DOI: 10.1016/j.molimm.2012.05.012
卷: 52, 期:3-4, 页:148-154
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Immunology
研究领域[WOS]: Biochemistry & Molecular Biology ; Immunology
关键词[WOS]: SERUM-AMYLOID-P ; AORTIC ENDOTHELIAL-CELLS ; APOPTOTIC CELLS ; COMPONENT BINDS ; PENTRAXIN PTX3 ; ACTIVATION ; RISK ; GRANULOMATOSIS ; AUTOANTIBODIES ; REARRANGEMENT
英文摘要:

Serum C-reactive protein (CRP) was one of the useful biomarkers for evaluating the disease activity in antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV). Cumulating studies proved that CRP was pathogenic in a variety of diseases. In the current study, the in vitro effects of CRP to prime neutrophils for ANCA-induced respiratory burst were investigated with flow cytometry. Without TNF-alpha in the reactive system, ANCA could only induce a slight level of respiratory burst of neutrophils. CRP could enhance the respiratory burst of neutrophils induced by ANCA against myeloperoxidse [mean fluorescence intensity (MFI, 68.45 +/- 16.87 vs. 58.65 +/- 15.09, P<0.05) or by ANCA against proteinase 3 (MFI, 79.51 +/- 15.90 vs. 61.73 +/- 14.89, P<0.05). Although CRP (50 mu g/mL, incubating for 30 min) could not active neutrophils alone, after incubation with neutrophils for 10 min, CRP (50 mu g/mL) could increase the expression of membrane proteinase 3 of neutrophils (MFI, 365.27 +/- 143.50 vs. 235.32 +/- 124.65, P<0.05). Heat-treated CRP could not enhance the levels of neutrophils respiratory burst induced by ANCA or increase the expression of membrane proteinase 3 of neutrophils. So CRP can prime neutrophils and enhance the respiratory burst induced by ANCA and might be pathogenic in AAV. (C) 2012 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 2012CB517702 ; 30972733 ; 81021004
项目资助者: Chinese 973 project ; National Natural Science Fund
WOS记录号: WOS:000307489800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66608
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Hosp 1, Dept Med, Div Renal, Beijing 100034, Peoples R China
2.Peking Univ, Inst Nephrol, Beijing 100034, Peoples R China
3.Minist Hlth China, Key Lab Renal Dis, Beijing 100034, Peoples R China
4.Minist Educ China, Key Lab CKD Prevent & Treatment, Beijing 100034, Peoples R China
5.Tianjin Med Univ, Gen Hosp, Dept Nephrol, Tianjin 300052, Peoples R China

Recommended Citation:
Xu, Peng-cheng,Hao, Jian,Yang, Xiao-wei,et al. C-reactive protein enhances the respiratory burst of neutrophils-induced by antineutrophil cytoplasmic antibody[J]. MOLECULAR IMMUNOLOGY,2012,52(3-4):148-154.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Xu, Peng-cheng]'s Articles
[Hao, Jian]'s Articles
[Yang, Xiao-wei]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Xu, Peng-cheng]‘s Articles
[Hao, Jian]‘s Articles
[Yang, Xiao-wei]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace