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A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel
Yang, Yang; Wang, JianCheng; Zhang, Xuan; Lu, WangLiang; Zhang, Qiang
关键词Mixed micelle gel Thermo-sensitive Anti-tumor effect Peritumoral Intratumoral
刊名JOURNAL OF CONTROLLED RELEASE
2009-04-17
DOI10.1016/j.jconrel.2009.01.007
135期:2页:175-182
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]BIODEGRADABLE BLOCK-COPOLYMERS ; SUSTAINED-RELEASE ; IN-VITRO ; DRUG-DELIVERY ; BREAST-CANCER ; TRIBLOCK COPOLYMERS ; OVARIAN-CARCINOMA ; AQUEOUS-SOLUTIONS ; CELL-LINES ; PACLITAXEL
英文摘要

In the present study, we incorporated docetaxel (DTX) into an injectable thermo-sensitive mixed micelle gel (MMG). It was found that the mixed micelle composed Of Pluronic F127 (PF127) and Tween 80 overcame the problem of PF127 micelle on physical stability and drug release due to the low solubilization capacity of PF127 for the high lipophility of DTX molecules. Then, DTX MMG was characterized in vitro and in vivo, compared with DTX PF127 gel and free DTX. The sulforhodamine B (SRB) staining assay in both human breast cancer MCF-7 and ovarian cancer SKOV-3 cell lines revealed that DTX loaded mixed micelles generated the highest cytotoxicity. Different local administrations, including intratumoral (i.t.), peritumoral (p.t.) and subcutaneous (s.c.) injections were compared and optimized in SKOV-3 ovarian tumor-xenograft bearing mice. Among these, the i.t. delivery of DTX MMG proved to be most effective. Moreover, it was demonstrated in the pharmacokinetic evaluation of DTX MMG that DTX remained in the tumor mass for more than six days post i.t. injection; likewise, we found that it correlated well with the in vitro release. During the observation period, there were no deaths, visible toxicity, nor obvious necrosis at the injection sites observed in all the animals tested. These results suggested that this injectable MMG system, provided a promising locally delivered vehicle for hydrophobic anti-tumor agents to increase their efficacy and thereby improved their therapeutic effect for clinical treatment. (c) 2009 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000265503900011
项目编号2007CB935901 ; 2009CB930300
资助机构National Basic Research Program
引用统计
被引频次:83[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66609
专题北京大学药学院
北京大学药学院_药剂学系
作者单位Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100083, Peoples R China
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GB/T 7714
Yang, Yang,Wang, JianCheng,Zhang, Xuan,et al. A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel[J]. JOURNAL OF CONTROLLED RELEASE,2009,135(2):175-182.
APA Yang, Yang,Wang, JianCheng,Zhang, Xuan,Lu, WangLiang,&Zhang, Qiang.(2009).A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel.JOURNAL OF CONTROLLED RELEASE,135(2),175-182.
MLA Yang, Yang,et al."A novel mixed micelle gel with thermo-sensitive property for the local delivery of docetaxel".JOURNAL OF CONTROLLED RELEASE 135.2(2009):175-182.
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