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Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats
Li, Yu-ling1; Liu, Qing1; Gong, Qi1; Li, Jun-xu2; Wei, Shou-peng1; Wang, Yan-ting1; Liang, Hui1; Zhang, Min1; Jing, Li2; Yong, Zheng3; Lawrence, Andrew J.4; Liang, Jian-hui1
关键词alcoholism ethanol brucine glycine receptor antagonist Fawn-Hooded (FH/Wjd) rat
刊名ACTA PHARMACOLOGICA SINICA
2014-07-01
DOI10.1038/aps.2014.28
35期:7页:853-861
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
关键词[WOS]CONDITIONED PLACE PREFERENCE ; GLYCINE RECEPTOR FUNCTION ; STRYCHNOS-NUX-VOMICA ; ANIMAL-MODEL ; FH/WJD RAT ; CONSUMPTION ; ACAMPROSATE ; MORPHINE ; RELAPSE ; SEEKING
英文摘要

Aim: Brucine (BRU) extracted from the seeds of Strychnos nux-vomica L is glycine receptor antagonist. We hypothesize that BRU may modify alcohol consumption by acting at glycine receptors, and evaluated the pharmacodynamic profiles and adverse effects of BRU in rat models of alcohol abuse.

Methods: Alcohol-preferring Fawn-Hooded (FH/Wjd) rats were administered BRU (10, 20 or 30 mg/kg, sc). The effects of BRU on alcohol consumption were examined in ethanol 2-bottle-choice drinking paradigm, ethanol/sucrose operant self-administration paradigm and 5-d ethanol deprivation test. In addition, open field test was used to assess the general locomotor activity of FH/Wjd rats, and conditioned place preference (CPP) was conducted to assess conditioned reinforcing effect.

Results: In ethanol 2-bottle-choice drinking paradigm, treatment with BRU for 10 consecutive days dose-dependently decreased the ethanol intake associated with a compensatory increase of water intake, but unchanged the daily total fluid intake and body weight. In ethanol/sucrose operant self-administration paradigms, BRU (30 mg/kg) administered before each testing session significantly decreased the number of lever presses for ethanol and the ethanol intake, without affecting the number of sucrose (10%) responses, total sucrose intake, and the number of lever presses for water. Acute treatment with BRU (30 mg/kg) completely suppressed the deprivation-induced elevation of ethanol consumption. Treatment with BRU (10, 20, and 30 mg/kg) did not alter locomotion of FH/Wjd rats, nor did it produce place preference or aversion.

Conclusion: BRU selectively decreases ethanol consumption with minimal adverse effects. Therefore, BRU may represent a new pharmacotherapy for alcoholism.

语种英语
WOS记录号WOS:000338910500001
项目编号30870894 ; 81373390 ; 2009CB522000 ; 2011BAK04B08 ; 2009ZDYJHLJT003 ; R01DA034806 ; R21DA033426
资助机构National Natural Science Foundation of China ; National Basic Research Program of China ; National Key Technology R&amp ; D Program of China ; Key Research Items of Ministry of Public Security ; National Institute on Drug Abuse at the National Institutes of Health ; Victorian Government&prime ; s Operational Infrastructure Support Scheme
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66615
专题中国药物依赖性研究所
北京大学药学院_分子与细胞药理学系
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100191, Peoples R China
2.SUNY Buffalo, Sch Med & Biomed Sci, Dept Pharmacol & Toxicol, Buffalo, NY 14214 USA
3.Acad Mil Med Sci, Inst Pharmacol & Toxicol, Beijing 100850, Peoples R China
4.Univ Melbourne, Florey Inst Neurosci & Mental Hlth, Parkville, Vic 3010, Australia
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GB/T 7714
Li, Yu-ling,Liu, Qing,Gong, Qi,et al. Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats[J]. ACTA PHARMACOLOGICA SINICA,2014,35(7):853-861.
APA Li, Yu-ling.,Liu, Qing.,Gong, Qi.,Li, Jun-xu.,Wei, Shou-peng.,...&Liang, Jian-hui.(2014).Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats.ACTA PHARMACOLOGICA SINICA,35(7),853-861.
MLA Li, Yu-ling,et al."Brucine suppresses ethanol intake and preference in alcohol-preferring Fawn-Hooded rats".ACTA PHARMACOLOGICA SINICA 35.7(2014):853-861.
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