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学科主题: 临床医学
题名:
Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model
作者: Yuan, Jing; Ren, Han-yun; Shi, Yong-jin; Liu, Wei
关键词: Graft-versus-host disease ; Murine model ; CCR5 blockade ; Chemotaxis
刊名: INFLAMMATION RESEARCH
发表日期: 2015-02-01
DOI: 10.1007/s00011-014-0793-6
卷: 64, 期:2, 页:137-144
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Immunology
研究领域[WOS]: Cell Biology ; Immunology
关键词[WOS]: STEM-CELL TRANSPLANTATION ; T-CELLS ; EXPRESSION ; MICE ; INFLAMMATION ; MARAVIROC ; RESPONSES ; GVHD
英文摘要:

One characteristic feature of graft-versus-host disease (GVHD) is lymphocytes′ trafficking and recruitment to target tissues, and CCR5 plays a key role in the process. Thus, blockade of lymphocytes′ chemotaxis may attenuate GVHD.

We tested the effects of CCR5 blockade using an established murine model. The mean survival time, body weight change, and clinical GVHD scores were assessed. Concentrations of cytokines and chemokines, the CCR5, CXCR3, and CCR7 expressions on T lymphocytes, and histological changes of visceral organs were also evaluated. Additionally, we assessed the immunophenotype of infiltration cells in liver and intestine.

Mice undergoing total body irradiation and allogenic hematopoietic stem cell transplantation (allo-HSCT) developed typical GVHD. MVC increased CCR5 expression whereas CCR7 and CXCR3 expression were unaffected. MVC also increased plasma levels of the ligands of CCR5. A combination of MVC with CsA significantly alleviated the degree of visceral injuries and prolonged survival time.

MVC has a synergistic effect with CsA. It can attenuate the severity of GVHD and increase survival rate of mice in our murine model. This may offer a novel therapeutic perspective for clinical GVHD after allo-HSCT.

语种: 英语
所属项目编号: 81370667
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000347826400006
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66618
Appears in Collections:北京大学第一临床医学院_血液内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China

Recommended Citation:
Yuan, Jing,Ren, Han-yun,Shi, Yong-jin,et al. Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model[J]. INFLAMMATION RESEARCH,2015,64(2):137-144.
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