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学科主题临床医学
Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model
Yuan, Jing; Ren, Han-yun; Shi, Yong-jin; Liu, Wei
关键词Graft-versus-host disease Murine model CCR5 blockade Chemotaxis
刊名INFLAMMATION RESEARCH
2015-02-01
DOI10.1007/s00011-014-0793-6
64期:2页:137-144
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Immunology
研究领域[WOS]Cell Biology ; Immunology
关键词[WOS]STEM-CELL TRANSPLANTATION ; T-CELLS ; EXPRESSION ; MICE ; INFLAMMATION ; MARAVIROC ; RESPONSES ; GVHD
英文摘要

One characteristic feature of graft-versus-host disease (GVHD) is lymphocytes′ trafficking and recruitment to target tissues, and CCR5 plays a key role in the process. Thus, blockade of lymphocytes′ chemotaxis may attenuate GVHD.

We tested the effects of CCR5 blockade using an established murine model. The mean survival time, body weight change, and clinical GVHD scores were assessed. Concentrations of cytokines and chemokines, the CCR5, CXCR3, and CCR7 expressions on T lymphocytes, and histological changes of visceral organs were also evaluated. Additionally, we assessed the immunophenotype of infiltration cells in liver and intestine.

Mice undergoing total body irradiation and allogenic hematopoietic stem cell transplantation (allo-HSCT) developed typical GVHD. MVC increased CCR5 expression whereas CCR7 and CXCR3 expression were unaffected. MVC also increased plasma levels of the ligands of CCR5. A combination of MVC with CsA significantly alleviated the degree of visceral injuries and prolonged survival time.

MVC has a synergistic effect with CsA. It can attenuate the severity of GVHD and increase survival rate of mice in our murine model. This may offer a novel therapeutic perspective for clinical GVHD after allo-HSCT.

语种英语
WOS记录号WOS:000347826400006
项目编号81370667
资助机构National Natural Science Foundation of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66618
专题北京大学第一临床医学院_血液内科
作者单位Peking Univ, Hosp 1, Dept Hematol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yuan, Jing,Ren, Han-yun,Shi, Yong-jin,et al. Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model[J]. INFLAMMATION RESEARCH,2015,64(2):137-144.
APA Yuan, Jing,Ren, Han-yun,Shi, Yong-jin,&Liu, Wei.(2015).Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model.INFLAMMATION RESEARCH,64(2),137-144.
MLA Yuan, Jing,et al."Prophylaxis of acute graft-versus-host disease by CCR5 blockade combined with cyclosporine A in a murine model".INFLAMMATION RESEARCH 64.2(2015):137-144.
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