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学科主题: 口腔医学
题名:
Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling
作者: Zeng, QH; Li, SL; Chepeha, DB; Giordano, TJ; Li, J; Zhang, HL; Polverini, PJ; Nor, J; Kitajewski, J; Wang, CY
刊名: CANCER CELL
发表日期: 2005-07-01
DOI: 10.1016/j.ccr.2005.06.004
卷: 8, 期:1, 页:13-23
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Cell Biology
研究领域[WOS]: Oncology ; Cell Biology
关键词[WOS]: ELEGANS VULVAL DEVELOPMENT ; FACTOR INHIBITS ANOIKIS ; NF-KAPPA-B ; GROWTH-FACTOR ; EMBRYONIC LETHALITY ; ACT UPSTREAM ; ORAL-CANCER ; NECK-CANCER ; HEAD ; EXPRESSION
英文摘要:

While significant progress has been made in understanding the induction of tumor vasculature by secreted angiogenic factors, little is known regarding contact-dependent signals that promote tumor angiogenesis. Here, we report that the Notch ligand Jagged1 induced by growth factors via mitogen-activating protein kinase (MAPK) in head and neck squamous cell carcinoma (HNSCC) cells triggered Notch activation in neighboring endothelial cells (ECs) and promoted capillary-like sprout formation. Jagged1-expressing HNSCC cells significantly enhanced neovascularization and tumor growth in vivo. Moreover, the level of Jagged1 was significantly correlated with tumor blood vessel content and associated with HNSCC development. Our results elucidate a novel mechanism by which the direct interplay between tumor cells and ECs promotes angiogenesis through MAPK and Notch signaling pathways.

语种: 英语
WOS记录号: WOS:000230813800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66620
Appears in Collections:北京大学口腔医学院_期刊论文

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作者单位: 1.Univ Michigan, Sch Med & Dent, Dept Biol & Mat Sci, Lab Mol Signaling & Apoptosis, Ann Arbor, MI 48109 USA
2.Univ Michigan, Sch Med & Dent, Dept Otorhinolaryngol, Ann Arbor, MI 48109 USA
3.Univ Michigan, Sch Med & Dent, Canc Ctr Tissue Core, Ann Arbor, MI 48109 USA
4.Univ Michigan, Sch Med & Dent, Dept Oral Med Pathol & Oncol, Ann Arbor, MI 48109 USA
5.Univ Michigan, Sch Med & Dent, Dept Cariol Restorat Sci & Endodont, Ann Arbor, MI 48109 USA
6.Peking Univ, Sch Stomatol, Dept Oral & Maxillofacial Surg, Beijing 100081, Peoples R China
7.Columbia Univ, Coll Phys & Surg, Dept Pathol & Obstet & Gynecol, New York, NY 10032 USA

Recommended Citation:
Zeng, QH,Li, SL,Chepeha, DB,et al. Crosstalk between tumor and endothelial cells promotes tumor angiogenesis by MAPK activation of Notch signaling[J]. CANCER CELL,2005,8(1):13-23.
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