|Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions|
|Po, SS; Scherlag, BJ; Yamanashi, WS; Edwards, J; Zhou, J; Wu, R; Geng, N; Lazzara, R; Jackman, WM|
|关键词||paroxysmal atrial fibrillation autonomic nervous system fat pad pulmonary vein rotor complex fractionated atrial electrogram dominant frequency|
|WOS标题词||Science & Technology|
|类目[WOS]||Cardiac & Cardiovascular Systems|
|研究领域[WOS]||Cardiovascular System & Cardiology|
|关键词[WOS]||RADIOFREQUENCY ABLATION ; CATHETER ABLATION ; CANINE SINOATRIAL ; HEART-FAILURE ; STIMULATION ; INITIATION ; SUBSTRATE ; ROTORS ; DOGS|
BACKGROUND The mechanism(s) by which pulmonary veins (PVs) become ectopically active and subsequently initiate and sustain atrial fibrillation (AF) remains poorly understood.
OBJECTIVES The purpose of this study was to produce air acute canine model of paroxysmal AF arising from the PVs.
METHODS In 11 dogs, a thoracotomy was performed and a 26-gauge needle with a polyethylene tube attached was inserted into a fat pad containing autonomic ganglia at the base of the PV. The I I dogs were divided into two groups: acetylcholine (ACh) 1-10 mM (group 1, n = 5) or carbachol (CARB) 1-10 mM (group 11, n = 6) injected (0.5 mL) into the fat pad.
RESULTS Within 2 to 5 minutes after injection of parasympathomimetics into the fat pad, a sequence of heart rate slowing, spontaneous premature depolarizations, and spontaneous AF was observed in four of 11 dogs. In seven dogs, single premature extrastimuli easily induced AF. AF was sustained for an average of 10 minutes (ACh) and 38 minutes (CARB), with the shortest AF cycle length seen at the PV-atrial junction adjacent to the fat pad (AF cycle length 75 +/- 41 ins for ACh and 37 +/- 12 ms for CARB).
CONCLUSION Acute autonomic remodeling produced by injection of parasympathomimetics into the fat pad resulted in spontaneous or easily induced sustained AF with short AF cycle length; the most rapid firing rate was observed in the PV and atria adjacent to the injected fat pad. These findings resemble paroxysmal AF in patients, suggesting that hyperactive autonomic ganglia may be a critical element in patients exhibiting focal AF arising from the PV.
|作者单位||1.Univ Oklahoma, Hlth Sci Ctr, Cardiac Arrhythmia Res Inst, Oklahoma City, OK 73104 USA|
2.Endocardial Solut Inc, St Paul, MN USA
3.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
|Po, SS,Scherlag, BJ,Yamanashi, WS,et al. Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions[J]. HEART RHYTHM,2006,3(2):201-208.|
|APA||Po, SS.,Scherlag, BJ.,Yamanashi, WS.,Edwards, J.,Zhou, J.,...&Jackman, WM.(2006).Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions.HEART RHYTHM,3(2),201-208.|
|MLA||Po, SS,et al."Experimental model for paroxysmal atrial fibrillation arising at the pulmonary vein-atrial junctions".HEART RHYTHM 3.2(2006):201-208.|