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学科主题: 临床医学
题名:
No regional difference in cisatracurium dose-response and time-course-of-action between patients in China and Bosnia
作者: Dahaba, A. A.1; Suljevic, I.2; Bornemann, H.1; Wu, X. -M.3; Metzler, H.1
关键词: equipment, mechanomyograph ; monitoring, neuromuscular function ; neuromuscular block, cisatracurium
刊名: BRITISH JOURNAL OF ANAESTHESIA
发表日期: 2011-03-01
DOI: 10.1093/bja/aeq369
卷: 106, 期:3, 页:331-335
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Anesthesiology
研究领域[WOS]: Anesthesiology
关键词[WOS]: NEUROMUSCULAR BLOCKING-AGENTS ; CLINICAL-RESEARCH PRACTICE ; RELAXOMETER MECHANOMYOGRAPH ; ADDUCTOR POLLICIS ; ROCURONIUM ; PROPOFOL ; ANESTHESIA ; PHARMACOLOGY ; COMBINATION ; CAUCASIANS
英文摘要:

Background. Variability in drug response could result from a variety of genetic and environmental factors that are often hard to define or quantify. A number of studies demonstrated regional geographic variations in potency of neuromuscular blocking agents (NMBAs). The aim of our study was to compare dose-response and time-course-of-action of cisatracurium besylate, an NMBA eliminated via the Hoffman degradation, in two countries with different life habits, diet, and ambient conditions; being Han Chinese in China and Caucasians in Bosnia.

Methods. Neuromuscular block of cisatracurium 20 mu g kg(-1), followed by four incremental 10 mu g kg(-1) doses, and the remainder of 100 mu g kg(-1) was evaluated using the Relaxometer mechanomyograph (Groningen University, Groningen, The Netherlands). Dose-response curves were created using log-dose-probit-response transformation.

Results. There were no significant differences in cisatracurium mean (95% confidence intervals) ED50, ED90, and ED95 (effective doses for 50%, 90%, and 95% first twitch depression) in Caucasian [39.1 (35.7-42.3), 50.6 (45.5-54.3), and 54.4 (49.8-58.9) mu g kg(-1)] compared with Chinese patients [39.2 (35.1-43.1), 52.4 (47.9-56.8), and 56.9 (52.8-61.9) mu g kg(-1)], respectively. There were no significant differences in mean (SD) Dur(25) and Dur(0.9) (time until 25% first twitch and 0.9 train-of-four ratio recoveries) in Caucasian [47.1 (6.4) and 77.5 (9.1) min)] compared with Chinese patients [(45.9 (4.7) and 72.3 (9.1) min)], respectively.

Conclusions. Cisatracurium dose-response relationship and time-course-of-action were not influenced by geographic location. Thus, cisatracurium would not require dose adjustments between patients living in the two geographic locations.

语种: 英语
项目资助者: Medical University of Graz
WOS记录号: WOS:000287246700008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66626
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.Med Univ Graz, Dept Anaesthesiol & Intens Care Med, A-8036 Graz, Austria
2.Univ Sarajevo, Dept Anaesthesiol, Ctr Clin, Sarajevo 71000, Bosnia & Herceg
3.Peking Univ, Dept Anaesthesiol, Affiliated Hosp 1, Beijing 100871, Peoples R China

Recommended Citation:
Dahaba, A. A.,Suljevic, I.,Bornemann, H.,et al. No regional difference in cisatracurium dose-response and time-course-of-action between patients in China and Bosnia[J]. BRITISH JOURNAL OF ANAESTHESIA,2011,106(3):331-335.
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