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Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics
Xiang, Qian; Cui, Yimin; Zhao, Xia; Zhao, Nan
关键词Chinese genetic polymorphism PEAR1 pharmacodynamics prasugrel
刊名PHARMACOGENOMICS
2013-07-01
DOI10.2217/PGS.13.108
14期:10页:1179-1189
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]PLATELET REACTIVITY ; LOCI ; AGGREGABILITY ; AGGREGATION ; VARIABILITY ; ACTIVATION ; OUTCOMES ; VARIANT ; IMPACT ; GENE
英文摘要

Aim: The present study aimed to investigate PEAR1 genetic polymorphisms and pharmacogenetic variability in the pharmacodynamics of prasugrel, a new oral antiplatelet agent, in healthy Han Chinese subjects. Patients & methods: The inhibition of adenosine diphosphate-induced platelet aggregation was measured pre- and post-administration using the VerifyNow (R) P2Y12 assay. The genetic sequence of PEAR1 exons and previously reported SNPs in the PEAR1 gene were investigated. Results: A total of 28 variations were identified in PEAR1. The SNPs in two regions of the PEAR1 gene, from rs3737224 to rs822442, and from rs1214331 to rs12566888, probably play important roles in prasugrel pharmacodynamics. Conclusion: Further studies with larger sample sizes are recommended to explore the clinical importance of PEAR1 SNPs in prasugrel and other antiplatelet therapies.

语种英语
WOS记录号WOS:000330375800013
项目编号81273592 ; 81202592
资助机构National Natural Science Foundation of PR China
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66630
专题北京大学第一临床医学院
北京大学第一临床医学院_药剂科
北京大学第二临床医学院_党委院长办公室
作者单位Peking Univ, Hosp 1, Dept Pharm Base Clin Trial, Beijing 100034, Peoples R China
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GB/T 7714
Xiang, Qian,Cui, Yimin,Zhao, Xia,et al. Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics[J]. PHARMACOGENOMICS,2013,14(10):1179-1189.
APA Xiang, Qian,Cui, Yimin,Zhao, Xia,&Zhao, Nan.(2013).Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics.PHARMACOGENOMICS,14(10),1179-1189.
MLA Xiang, Qian,et al."Identification of PEAR1 SNPs and their influences on the variation in prasugrel pharmacodynamics".PHARMACOGENOMICS 14.10(2013):1179-1189.
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