IR@PKUHSC  > 北京大学第二临床医学院  > 肝胆外科
学科主题临床医学
De novo malignancy after liver transplantation: a single-center experience of 14 cases
Gao, Peng Ji; Gao, Jie; Li, Zhao; Hu, Zhi Ping; Zhu, Ji Ye
关键词Liver transplantation Transplant recipients Neoplasms Incidence
刊名ANNALS OF SURGICAL TREATMENT AND RESEARCH
2015-04-01
DOI10.4174/astr.2015.88.4.222
88期:4页:222-228
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Surgery
资助者Beijing Medicine Research and Development Fund ; Health Industry Scientific Research Fund of China ; Beijing Medicine Research and Development Fund ; Health Industry Scientific Research Fund of China
研究领域[WOS]Surgery
关键词[WOS]RISK-FACTORS ; SKIN-CANCER ; RECIPIENTS ; DATABASE
英文摘要

Purpose: The aim of this study is to evaluate the incidence of de nova malignancy after Liver transplantation (LT) and compare with those among the general Chinese population.

Methods: A total of 466 patients who had a minimum follow-up time of 6 months were enrolled in the study. All data of medical records and follow up were retrospectively reviewed.

Results: The incidence rate of de nova malignancy was 3.0% (14 in 466 patients). The median elapsed time from transplant to the diagnosis of de nova malignancy was 42 months (range, 6 to 106 months). The cumulative risk for development of de nova malignancy was 1.6%, 2.7%, and 8.2% at 3, 5 and 10 years after LT, respectively. The patients were all male. The types of de nova tumors included digestive system tumor (8 in 14), lung cancer (2 in 14), urologic neoplasm (2 in 14), and hematologic malignant tumor (2 in 14). Over a mean follow-up of 24 months after diagnosis of de nova malignancy, 7 patients (50.0%) died; the overall 5-year patient survival rate was 54.5%. The relative risk of malignancy following LT was 9.5 folds higher than the general Chinese population.

Conclusion: The relative risk of malignancy following LT was much higher than the general Chinese population. Digestive system tumor is the most common type of de nova malignancy after LT in China.

语种英语
所属项目编号20092029 ; 201002015
资助者Beijing Medicine Research and Development Fund ; Health Industry Scientific Research Fund of China ; Beijing Medicine Research and Development Fund ; Health Industry Scientific Research Fund of China
WOS记录号WOS:000352049900007
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66639
Collection北京大学第二临床医学院_肝胆外科
作者单位Peking Univ, Peoples Hosp, Dept Hepatobiliary Surg, Beijing 100044, Peoples R China
Recommended Citation
GB/T 7714
Gao, Peng Ji,Gao, Jie,Li, Zhao,et al. De novo malignancy after liver transplantation: a single-center experience of 14 cases[J]. ANNALS OF SURGICAL TREATMENT AND RESEARCH,2015,88(4):222-228.
APA Gao, Peng Ji,Gao, Jie,Li, Zhao,Hu, Zhi Ping,&Zhu, Ji Ye.(2015).De novo malignancy after liver transplantation: a single-center experience of 14 cases.ANNALS OF SURGICAL TREATMENT AND RESEARCH,88(4),222-228.
MLA Gao, Peng Ji,et al."De novo malignancy after liver transplantation: a single-center experience of 14 cases".ANNALS OF SURGICAL TREATMENT AND RESEARCH 88.4(2015):222-228.
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