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学科主题: 临床医学
题名:
The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes
作者: Hao, Yang1; Yang, Junyu1; Yin, Shenyi1; Zhang, Hanshuo1; Fan, Yu1; Sun, Changhong1; Gu, Jin2; Xi, Jianzhong Jeff1,3
关键词: miR-190 ; VEGF ; angiogenesis ; synergistic effect ; metastasis
刊名: RNA-A PUBLICATION OF THE RNA SOCIETY
发表日期: 2014-08-01
DOI: 10.1261/rna.044651.114
卷: 20, 期:8, 页:1328-1336
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: ENDOTHELIAL-CELLS ; GROWTH-FACTOR ; MICRORNA ; CANCER ; EXPRESSION ; METASTASIS ; TUMORIGENESIS ; INTEGRATION ; DELIVERY ; INSIGHTS
英文摘要:

VEGF is a major contributor to angiogenesis, a vital process in normal growth and development and tumor transition. However, the current clinical efficacy of VEGF inhibitors is limited, and the molecular mechanism underlying VEGF regulation remains to be elucidated. Here we show that miR-190 directly targets a group of angiogenic effectors besides VEGF per se. Noted, these effectors can transcriptionally regulate VEGF expression in an intracellular or intercellular manner, thus demonstrating that miR-190 modulates the VEGF-mediated tumor angiogenesis at three levels. The synergistic effect of miR-190 and its target genes demonstrates a complex but apparently more stable system, allowing for the tight control of the level of VEGF. Finally, we showed that miR-190 significantly suppresses tumor metastasis, especially angiogenesis. Together, these results indicate that miR-190 is a promising antitumor target in clinical applications.

语种: 英语
所属项目编号: 2011CB809106 ; 2013CB917803 ; 81030040 ; 31371443 ; 30600142
项目资助者: MOST ; NSFC
WOS记录号: WOS:000339176800014
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66640
Appears in Collections:北京大学临床肿瘤学院_期刊论文

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作者单位: 1.Peking Univ, Engn Coll, Biomed Engn Dept, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing 100142, Peoples R China
3.Peking Univ, Inst Mol Med, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China

Recommended Citation:
Hao, Yang,Yang, Junyu,Yin, Shenyi,et al. The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes[J]. RNA-A PUBLICATION OF THE RNA SOCIETY,2014,20(8):1328-1336.
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