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The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes
Hao, Yang1; Yang, Junyu1; Yin, Shenyi1; Zhang, Hanshuo1; Fan, Yu1; Sun, Changhong1; Gu, Jin2; Xi, Jianzhong Jeff1,3
关键词miR-190 VEGF angiogenesis synergistic effect metastasis
刊名RNA-A PUBLICATION OF THE RNA SOCIETY
2014-08-01
DOI10.1261/rna.044651.114
20期:8页:1328-1336
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]ENDOTHELIAL-CELLS ; GROWTH-FACTOR ; MICRORNA ; CANCER ; EXPRESSION ; METASTASIS ; TUMORIGENESIS ; INTEGRATION ; DELIVERY ; INSIGHTS
英文摘要

VEGF is a major contributor to angiogenesis, a vital process in normal growth and development and tumor transition. However, the current clinical efficacy of VEGF inhibitors is limited, and the molecular mechanism underlying VEGF regulation remains to be elucidated. Here we show that miR-190 directly targets a group of angiogenic effectors besides VEGF per se. Noted, these effectors can transcriptionally regulate VEGF expression in an intracellular or intercellular manner, thus demonstrating that miR-190 modulates the VEGF-mediated tumor angiogenesis at three levels. The synergistic effect of miR-190 and its target genes demonstrates a complex but apparently more stable system, allowing for the tight control of the level of VEGF. Finally, we showed that miR-190 significantly suppresses tumor metastasis, especially angiogenesis. Together, these results indicate that miR-190 is a promising antitumor target in clinical applications.

语种英语
WOS记录号WOS:000339176800014
项目编号2011CB809106 ; 2013CB917803 ; 81030040 ; 31371443 ; 30600142
资助机构MOST ; NSFC
引用统计
被引频次:14[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66640
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_结直肠肿瘤外科
作者单位1.Peking Univ, Engn Coll, Biomed Engn Dept, Beijing 100871, Peoples R China
2.Peking Univ, Beijing Canc Hosp, Sch Oncol, Beijing 100142, Peoples R China
3.Peking Univ, Inst Mol Med, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100871, Peoples R China
推荐引用方式
GB/T 7714
Hao, Yang,Yang, Junyu,Yin, Shenyi,et al. The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes[J]. RNA-A PUBLICATION OF THE RNA SOCIETY,2014,20(8):1328-1336.
APA Hao, Yang.,Yang, Junyu.,Yin, Shenyi.,Zhang, Hanshuo.,Fan, Yu.,...&Xi, Jianzhong Jeff.(2014).The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes.RNA-A PUBLICATION OF THE RNA SOCIETY,20(8),1328-1336.
MLA Hao, Yang,et al."The synergistic regulation of VEGF-mediated angiogenesis through miR-190 and target genes".RNA-A PUBLICATION OF THE RNA SOCIETY 20.8(2014):1328-1336.
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