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学科主题: 临床医学
题名:
Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia
作者: Yang, Ting1,2,3,4; Zhuang, Lei1,2; Fidalgo, Antonio M. Rei1,2; Petrides, Evgenia1,2; Terrando, Niccolo4; Wu, Xinmin4; Sanders, Robert D.1,2; Robertson, Nicola J.5; Johnson, Mark R.1,2; Maze, Mervyn4; Ma, Daqing1,2
刊名: PLOS ONE
发表日期: 2012-05-17
DOI: 10.1371/journal.pone.0037020
卷: 7, 期:5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: D-ASPARTATE RECEPTOR ; NITROUS-OXIDE ; NEONATAL ASPHYXIA ; COMPETITIVE-INHIBITION ; GLYCINE SITE ; IN-VITRO ; INJURY ; ISOFLURANE ; DAMAGE ; ENCEPHALOPATHY
英文摘要:

It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agents with presumptive analgesic activity and known preconditioning-neuroprotective properties (sevoflurane or xenon), in reducing hypoxia-induced brain damage in a model of intrauterine perinatal asphyxia. The analgesic and neuroprotective effects at subanesthetic levels of sevoflurane (0.35%) or xenon (35%) were tested in a rat model of intrauterine perinatal asphyxia. Analgesic effects were measured by assessing maternal behavior and spinal cord dorsal horn neuronal activation using c-Fos. In separate experiments, intrauterine fetal asphyxia was induced four hours after gas exposure; on post-insult day 3 apoptotic cell death was measured by caspase-3 immunostaining in hippocampal neurons and correlated with the number of viable neurons on postnatal day (PND) 7. A separate cohort of pups was nurtured by a surrogate mother for 50 days when cognitive testing with Morris water maze was performed. Both anesthetic agents provided analgesia as reflected by a reduction in the number of stretching movements and decreased c-Fos expression in the dorsal horn of the spinal cord. Both agents also reduced the number of caspase-3 positive (apoptotic) neurons and increased cell viability in the hippocampus at PND7. These acute histological changes were mirrored by improved cognitive function measured remotely after birth on PND 50 compared to control group. Subanesthetic doses of sevoflurane or xenon provided both analgesia and neuroprotection in this model of intrauterine perinatal asphyxia. These data suggest that anesthetic agents with neuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the future.

语种: 英语
所属项目编号: SP4385
项目资助者: Action Medical Research, West Sussex, UK ; Chinese Society of Anesthesiology, Beijing, China
WOS记录号: WOS:000305341200034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66642
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: 1.UCL, Inst Womens Hlth, London, England
2.Chelsea & Westminster Hosp, London, England
3.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London, England
4.Beijing Univ, Dept Anesthesia & Intens Care, Hosp 1, Beijing 100871, Peoples R China
5.Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA

Recommended Citation:
Yang, Ting,Zhuang, Lei,Fidalgo, Antonio M. Rei,et al. Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia[J]. PLOS ONE,2012,7(5).
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