IR@PKUHSC  > 北京大学第一临床医学院
学科主题临床医学
Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia
Yang, Ting1,2,3,4; Zhuang, Lei1,2; Fidalgo, Antonio M. Rei1,2; Petrides, Evgenia1,2; Terrando, Niccolo4; Wu, Xinmin4; Sanders, Robert D.1,2; Robertson, Nicola J.5; Johnson, Mark R.1,2; Maze, Mervyn4; Ma, Daqing1,2
刊名PLOS ONE
2012-05-17
DOI10.1371/journal.pone.0037020
7期:5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]D-ASPARTATE RECEPTOR ; NITROUS-OXIDE ; NEONATAL ASPHYXIA ; COMPETITIVE-INHIBITION ; GLYCINE SITE ; IN-VITRO ; INJURY ; ISOFLURANE ; DAMAGE ; ENCEPHALOPATHY
英文摘要

It is not possible to identify all pregnancies at risk of neonatal hypoxic-ischemic encephalopathy (HIE). Many women use some form of analgesia during childbirth and some anesthetic agents have been shown to be neuroprotective when used as analgesics at subanesthetic concentrations. In this study we sought to understand the effects of two anesthetic agents with presumptive analgesic activity and known preconditioning-neuroprotective properties (sevoflurane or xenon), in reducing hypoxia-induced brain damage in a model of intrauterine perinatal asphyxia. The analgesic and neuroprotective effects at subanesthetic levels of sevoflurane (0.35%) or xenon (35%) were tested in a rat model of intrauterine perinatal asphyxia. Analgesic effects were measured by assessing maternal behavior and spinal cord dorsal horn neuronal activation using c-Fos. In separate experiments, intrauterine fetal asphyxia was induced four hours after gas exposure; on post-insult day 3 apoptotic cell death was measured by caspase-3 immunostaining in hippocampal neurons and correlated with the number of viable neurons on postnatal day (PND) 7. A separate cohort of pups was nurtured by a surrogate mother for 50 days when cognitive testing with Morris water maze was performed. Both anesthetic agents provided analgesia as reflected by a reduction in the number of stretching movements and decreased c-Fos expression in the dorsal horn of the spinal cord. Both agents also reduced the number of caspase-3 positive (apoptotic) neurons and increased cell viability in the hippocampus at PND7. These acute histological changes were mirrored by improved cognitive function measured remotely after birth on PND 50 compared to control group. Subanesthetic doses of sevoflurane or xenon provided both analgesia and neuroprotection in this model of intrauterine perinatal asphyxia. These data suggest that anesthetic agents with neuroprotective properties may be effective in preventing HIE and should be tested in clinical trials in the future.

语种英语
WOS记录号WOS:000305341200034
项目编号SP4385
资助机构Action Medical Research, West Sussex, UK ; Chinese Society of Anesthesiology, Beijing, China
引用统计
被引频次:28[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66642
专题北京大学第一临床医学院
北京大学第三临床医学院_呼吸科
作者单位1.UCL, Inst Womens Hlth, London, England
2.Chelsea & Westminster Hosp, London, England
3.Univ London Imperial Coll Sci Technol & Med, Dept Surg & Canc, London, England
4.Beijing Univ, Dept Anesthesia & Intens Care, Hosp 1, Beijing 100871, Peoples R China
5.Univ Calif San Francisco, Dept Anesthesia & Perioperat Care, San Francisco, CA 94143 USA
推荐引用方式
GB/T 7714
Yang, Ting,Zhuang, Lei,Fidalgo, Antonio M. Rei,et al. Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia[J]. PLOS ONE,2012,7(5).
APA Yang, Ting.,Zhuang, Lei.,Fidalgo, Antonio M. Rei.,Petrides, Evgenia.,Terrando, Niccolo.,...&Ma, Daqing.(2012).Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia.PLOS ONE,7(5).
MLA Yang, Ting,et al."Xenon and Sevoflurane Provide Analgesia during Labor and Fetal Brain Protection in a Perinatal Rat Model of Hypoxia-Ischemia".PLOS ONE 7.5(2012).
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, Ting]的文章
[Zhuang, Lei]的文章
[Fidalgo, Antonio M. Rei]的文章
百度学术
百度学术中相似的文章
[Yang, Ting]的文章
[Zhuang, Lei]的文章
[Fidalgo, Antonio M. Rei]的文章
必应学术
必应学术中相似的文章
[Yang, Ting]的文章
[Zhuang, Lei]的文章
[Fidalgo, Antonio M. Rei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。