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学科主题基础医学
PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability
Liu, Yingying1,2; Lv, Kaosheng1,2; Li, Zenglong1,2; Yu, Albert C. H.4,5; Chen, Jianguo1,2,3; Teng, Junlin1,2
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2012-11-16
DOI10.1074/jbc.M112.403451
287期:47
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]RECEPTOR-MEDIATED ENDOCYTOSIS ; CULTURED HIPPOCAMPAL-NEURONS ; SYNDAPIN-I ; DYNAMIC MICROTUBULES ; PHOSPHORYLATION ; ORGANIZATION ; ACTIN ; MEMBRANE ; ISOFORMS ; TUBULIN
英文摘要

Tau is a major member of the neuronal microtubule-associated proteins. It promotes tubulin assembly and stabilizes axonal microtubules. Previous studies have demonstrated that Tau forms cross-bridges between microtubules, with some particles located on cross-bridges, suggesting that some proteins interact with Tau and might be involved in regulating Tau-related microtubule dynamics. This study reports that PACSIN1 interacts with Tau in axon. PACSIN1 blockade results in impaired axonal elongation and a higher number of primary axonal branches in mouse dorsal root ganglia neurons, which is induced by increasing the binding ability of Tau to microtubules. In PACSIN1-blocked dorsal root ganglia neurons, a greater amount of Tau is inclined to accumulate in the central domain of growth cones, and it promotes the stability of the microtubule network. Taken together, these results suggest that PACSIN1 is an important Tau binding partner in regulating microtubule dynamics and forming axonal plasticity.

语种英语
WOS记录号WOS:000311233800059
项目编号30670659 ; 31071177 ; 2010CB833705
资助机构National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program)
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66649
专题北京大学基础医学院_神经生物学系
作者单位1.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Cell Proliferat & Differentiat, Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, State Key Lab Biomembrane & Membrane Bioengn, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Sch Basic Med Sci,Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
5.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Sch Basic Med Sci,Key Lab Neurosci,Minist Publ Hl, Beijing 100191, Peoples R China
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GB/T 7714
Liu, Yingying,Lv, Kaosheng,Li, Zenglong,et al. PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2012,287(47).
APA Liu, Yingying,Lv, Kaosheng,Li, Zenglong,Yu, Albert C. H.,Chen, Jianguo,&Teng, Junlin.(2012).PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability.JOURNAL OF BIOLOGICAL CHEMISTRY,287(47).
MLA Liu, Yingying,et al."PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability".JOURNAL OF BIOLOGICAL CHEMISTRY 287.47(2012).
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