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学科主题: 基础医学
题名:
PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability
作者: Liu, Yingying1,2; Lv, Kaosheng1,2; Li, Zenglong1,2; Yu, Albert C. H.4,5; Chen, Jianguo1,2,3; Teng, Junlin1,2
刊名: JOURNAL OF BIOLOGICAL CHEMISTRY
发表日期: 2012-11-16
DOI: 10.1074/jbc.M112.403451
卷: 287, 期:47
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology
研究领域[WOS]: Biochemistry & Molecular Biology
关键词[WOS]: RECEPTOR-MEDIATED ENDOCYTOSIS ; CULTURED HIPPOCAMPAL-NEURONS ; SYNDAPIN-I ; DYNAMIC MICROTUBULES ; PHOSPHORYLATION ; ORGANIZATION ; ACTIN ; MEMBRANE ; ISOFORMS ; TUBULIN
英文摘要:

Tau is a major member of the neuronal microtubule-associated proteins. It promotes tubulin assembly and stabilizes axonal microtubules. Previous studies have demonstrated that Tau forms cross-bridges between microtubules, with some particles located on cross-bridges, suggesting that some proteins interact with Tau and might be involved in regulating Tau-related microtubule dynamics. This study reports that PACSIN1 interacts with Tau in axon. PACSIN1 blockade results in impaired axonal elongation and a higher number of primary axonal branches in mouse dorsal root ganglia neurons, which is induced by increasing the binding ability of Tau to microtubules. In PACSIN1-blocked dorsal root ganglia neurons, a greater amount of Tau is inclined to accumulate in the central domain of growth cones, and it promotes the stability of the microtubule network. Taken together, these results suggest that PACSIN1 is an important Tau binding partner in regulating microtubule dynamics and forming axonal plasticity.

语种: 英语
所属项目编号: 30670659 ; 31071177 ; 2010CB833705
项目资助者: National Natural Science Foundation of China ; Major State Basic Research Development Program of China (973 Program)
WOS记录号: WOS:000311233800059
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66649
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Ctr Theoret Biol, Beijing 100871, Peoples R China
2.Peking Univ, Key Lab Cell Proliferat & Differentiat, Minist Educ, Beijing 100871, Peoples R China
3.Peking Univ, State Key Lab Biomembrane & Membrane Bioengn, Coll Life Sci, Beijing 100871, Peoples R China
4.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Sch Basic Med Sci,Key Lab Neurosci,Minist Educ, Beijing 100191, Peoples R China
5.Peking Univ, Neurosci Res Inst, Dept Neurobiol, Sch Basic Med Sci,Key Lab Neurosci,Minist Publ Hl, Beijing 100191, Peoples R China

Recommended Citation:
Liu, Yingying,Lv, Kaosheng,Li, Zenglong,et al. PACSIN1, a Tau-interacting Protein, Regulates Axonal Elongation and Branching by Facilitating Microtubule Instability[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2012,287(47).
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