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IR@PKUHSC  > 北京大学临床肿瘤学院  > 肿瘤内科  > 期刊论文
学科主题: 临床医学
题名:
Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences
作者: Ren, Jun1; Di, Lijun1; Song, Guohong1; Yu, Jing1; Jia, Jun1; Zhu, Yuling1; Yan, Ying1; Jiang, Hanfang1; Liang, Xu1; Che, Li1; Zhang, Jie1; Wan, Fengling1; Wang, Xiaoli1; Zhou, Xinna1; Lyerly, Herbert Kim1,2
关键词: Metastatic breast cancer ; High-dose chemotherapy ; Immunotherapy ; Dendritic cells ; Cytokine-induced killers
刊名: CLINICAL & TRANSLATIONAL ONCOLOGY
发表日期: 2013-10-01
DOI: 10.1007/s12094-013-1001-9
卷: 15, 期:10, 页:780-788
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: PHASE-III TRIAL ; RANDOMIZED-TRIAL ; STEM-CELLS ; ADJUVANT TREATMENT ; TRANSPLANTATION ; IMMUNOTHERAPY ; SUPPORT ; DOCETAXEL ; THIOTEPA ; DENSE
英文摘要:

We hypothesized that combination of dendritic cell (DC) with autologous cytokine-induced killer (CIK) immunotherapy in setting of high-dose chemotherapy (HDC) would be effective for selected metastatic breast cancer (MBC) patients.

Our previous work showed thiotepa could eradicate breast cancer stem cells. From 2004 to 2009, 79 patients received standard dose chemotherapy (SDC) of 75 mg/m(2) docetaxel and 75 mg/m(2) thiotepa versus 87 patients of HDC + DC/CIK: 120 mg/m(2) docetaxel to mobilize peripheral CD34(+) progenitor cells, a sequence of HDC (120 mg/m(2) docetaxel, plus 175 mg/m(2) thiotepa) + DC/CIK, with or without 400 mg/m(2) carboplatin depending upon bone marrow function. The endpoints were response rates (RR), progression-free survival (PFS), and overall survival (OS).

Compared with SDC, PFS and OS were improved in HDC + DC/CIK (median PFS 10.2 vs. 3.7 months, P < 0.001; median OS 33.1 vs. 15.2 months, P < 0.001). Patients of pre-menopausal, HDC as first-line treatment after metastasis, or with visceral metastasis showed prolonged PFS and OS. SDC group also achieved the similar response as previous reports.

Our study demonstrated the novel combination of HDC with DC/CIK to be an effective choice for the selected MBC population, in which choosing appropriate chemo regimens played important roles, and also specific HDC regimen plus DC/CIK immunotherapy showed the clinical benefits compared with chemotherapy alone.

语种: 英语
所属项目编号: 81172534 ; 2007-2053
项目资助者: Natural Science Foundation of China ; Beijing Capital Development Grant Beijing ; Duke-PKU Cancer Program
WOS记录号: WOS:000324556600004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66654
Appears in Collections:北京大学临床肿瘤学院_肿瘤内科_期刊论文

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作者单位: 1.Peking Univ, Canc Hosp & Inst, Dept Med Oncol, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
2.Duke Univ, Med Ctr, Durham, NC 27710 USA

Recommended Citation:
Ren, Jun,Di, Lijun,Song, Guohong,et al. Selections of appropriate regimen of high-dose chemotherapy combined with adoptive cellular therapy with dendritic and cytokine-induced killer cells improved progression-free and overall survival in patients with metastatic breast cancer: reargument of such contentious therapeutic preferences[J]. CLINICAL &amp; TRANSLATIONAL ONCOLOGY,2013,15(10):780-788.
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