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学科主题: 口腔医学
题名:
The expression of NF-kappa B, Ki-67 and MMP-9 in CCOT, DGCT and GCOC
作者: Gong, Yanling2,3; Wang, Li1,2; Wang, Hengkun4; Li, Tiejun5; Chen, Xinming1,2
关键词: Calcifying odontogenic cyst ; Nuclear factor kappa B ; Proliferation ; Matrix metalloproteinase ; Calcifying cystic odontogenic tumor (CCOT) ; Dentinogenic ghost cell tumor (DGCT) ; Ghost cell odontogenic carcinoma (GCOC)
刊名: ORAL ONCOLOGY
发表日期: 2009-06-01
DOI: 10.1016/j.oraloncology.2008.07.004
卷: 45, 期:6, 页:515-520
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
研究领域[WOS]: Oncology ; Dentistry, Oral Surgery & Medicine
关键词[WOS]: MATRIX METALLOPROTEINASES ; TUMOR PROGRESSION ; CELL CARCINOMA ; SQUAMOUS-CELL ; CANCER ; AMELOBLASTOMAS ; INHIBITORS ; ALPHA ; ADENOCARCINOMA ; LOCALIZATION
英文摘要:

Calcifying odontogenic cysts (COCs) represent a group of rare odontogenic lesions with a diversity of clinicopathological and behavioral features. According to the WHO classification of head and neck tumors in 2005, COC has been divided into calcifying cystic odontogenic tumor (CCOT), dentinogenic ghost cell tumor (DGCT) and ghost cell odontogenic carcinoma (GCOC). With few reports available on its immunohistochemical pro. le, this study investigated the histopathological features and the expression of nuclear factor kappa B (NF-kappa B), Ki-67 and matrix metalloproteinase-9 (MMP-9) in CCOT, DGCT and GCOC. According to the WHO classification of head and neck tumors in 2005, 26 cases of the so-called COC were diagnosed as CCOT (n = 14), DGCT (n = 7) and GCOC (n = 5), respectively. The specimens of 26 COCs and 10 classic ameloblastomas (as control group) were examined by immunohistochemistry using anti-NF-kappa B p65, anti-Ki67 and anti-MMP-9 antibodies and by in situ hybridization (ISH) using anti-MMP-9 mRNA probes. Immunohistochemical reactivity for NF-kappa B was mainly detected in the cytoplasm of tumor cells, and nuclear reactivity was only seen in few tumor cells in COC and classic ameloblastomas. Rate of nuclear staining was less than 1%. The expression of Ki-67 in GCOC was significantly higher than those in CCOT (p < 0.001), DGCT and ameloblastoma (p < 0.005). In COCs and ameloblastomas, expression of MMP-9 mRNA and protein was detected in tumor cells as well as in stromal cells. The positive staining for MMP-9 protein was detected in stromal cells of all GCOC cases and was significantly stronger than those in CCOT and DGCT groups (p < 0.05). NF-kappa B may minimally affect the progression and local invasiveness of CCOT, DGCT and GCOC. GCOC show significantly higher proliferative activity than CCOT and DGCT. MMP-9 in stroma is associated with invasive ability of the CCOT, DGCT and GCOC. (C) 2008 Elsevier Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000266271100015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66656
Appears in Collections:北京大学口腔医学院_口腔病理科_期刊论文

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作者单位: 1.Wuhan Univ, Sch & Hosp Stomatol, Dept Pathol, Wuhan 430072, Hubei, Peoples R China
2.Wuhan Univ, Sch & Hosp Stomatol, Minist Educ, Key Lab Oral Biomed Engn, Wuhan 430072, Hubei, Peoples R China
3.Second Hosp Weihai, Dept Stomatol, Weihai, Shandong, Peoples R China
4.Weihai Municipal Hosp, Weihai, Shandong, Peoples R China
5.Peking Univ, Sch & Hosp Stomatol, Dept Pathol, Beijing 100871, Peoples R China

Recommended Citation:
Gong, Yanling,Wang, Li,Wang, Hengkun,et al. The expression of NF-kappa B, Ki-67 and MMP-9 in CCOT, DGCT and GCOC[J]. ORAL ONCOLOGY,2009,45(6):515-520.
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