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学科主题: 临床医学
题名:
Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis
作者: Liu Li-Jia1; Wu Xiu-Wen1; Wang Ru-Feng1; Peng Yu-Shuai1; Yang Xin1; Liu Jun-Xiu2
关键词: Trolline ; veratric acid ; Trollius chinensis ; absorption ; Caco-2 cell monolayer model
刊名: CHINESE JOURNAL OF NATURAL MEDICINES
发表日期: 2014-09-01
DOI: 10.3724/SP.J.1009.2014.00700
卷: 12, 期:9, 页:700-704
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine ; Pharmacology & Pharmacy
研究领域[WOS]: Integrative & Complementary Medicine ; Pharmacology & Pharmacy
关键词[WOS]: C-GLYCOSIDES
英文摘要:

AIM: To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers.

METHOD: The human Caco-2 cell monolayer model was employed to study the transport of trolline and veratric acid from apical side (AP) to basal side (BL), and from BL to AP by determining the transport rates as the function of time and concentration and calculating apparent permeability coefficients (P-app).

RESULTS: Trolline and veratric acid were transported across Caco-2 cell monolayer through different mechanisms in a concentration dependent manner. Trolline was transported at a P-app level of 10(-6) cm.s(-1) with a P-app (AP -> BL)/P-app BL -> AP ratio of more than 1.8 or less than 0.8, while veratric acid was transported at a P-app level of 10(-5) cm.s(-1) with a P-app AP -> BL/P-app (BL -> AP) ratio of close to 1.0.

CONCLUSION: Trolline is moderately absorbed through an associative mechanism involving active and passive transport, and veratric acid is well-absorbed mainly through passive diffusion. These factors should be taken into account when chemically assessing the pharmacodynamic material basis of the flowers of T. chinensis.

语种: 英语
所属项目编号: 81073018 ; 81274044
项目资助者: National Sciences Foundation of China
WOS记录号: WOS:000343192100011
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66662
Appears in Collections:北京大学第三临床医学院_耳鼻喉科_期刊论文

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作者单位: 1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China

Recommended Citation:
Liu Li-Jia,Wu Xiu-Wen,Wang Ru-Feng,et al. Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(9):700-704.
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