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Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis
Liu Li-Jia1; Wu Xiu-Wen1; Wang Ru-Feng1; Peng Yu-Shuai1; Yang Xin1; Liu Jun-Xiu2
关键词Trolline veratric acid Trollius chinensis absorption Caco-2 cell monolayer model
刊名CHINESE JOURNAL OF NATURAL MEDICINES
2014-09-01
DOI10.3724/SP.J.1009.2014.00700
12期:9页:700-704
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
资助者National Sciences Foundation of China ; National Sciences Foundation of China
研究领域[WOS]Integrative & Complementary Medicine ; Pharmacology & Pharmacy
关键词[WOS]C-GLYCOSIDES
英文摘要

AIM: To study the absorption properties and mechanism of two important components, trolline and veratric acid, from the flowers of Trollius chinensis, in order to better understand the contribution of these two compounds to the effectiveness of these flowers.

METHOD: The human Caco-2 cell monolayer model was employed to study the transport of trolline and veratric acid from apical side (AP) to basal side (BL), and from BL to AP by determining the transport rates as the function of time and concentration and calculating apparent permeability coefficients (P-app).

RESULTS: Trolline and veratric acid were transported across Caco-2 cell monolayer through different mechanisms in a concentration dependent manner. Trolline was transported at a P-app level of 10(-6) cm.s(-1) with a P-app (AP -> BL)/P-app BL -> AP ratio of more than 1.8 or less than 0.8, while veratric acid was transported at a P-app level of 10(-5) cm.s(-1) with a P-app AP -> BL/P-app (BL -> AP) ratio of close to 1.0.

CONCLUSION: Trolline is moderately absorbed through an associative mechanism involving active and passive transport, and veratric acid is well-absorbed mainly through passive diffusion. These factors should be taken into account when chemically assessing the pharmacodynamic material basis of the flowers of T. chinensis.

语种英语
所属项目编号81073018 ; 81274044
资助者National Sciences Foundation of China ; National Sciences Foundation of China
WOS记录号WOS:000343192100011
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66662
专题北京大学第三临床医学院_耳鼻喉科
作者单位1.Beijing Univ Chinese Med, Sch Chinese Mat Med, Beijing 100102, Peoples R China
2.Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Liu Li-Jia,Wu Xiu-Wen,Wang Ru-Feng,et al. Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2014,12(9):700-704.
APA Liu Li-Jia,Wu Xiu-Wen,Wang Ru-Feng,Peng Yu-Shuai,Yang Xin,&Liu Jun-Xiu.(2014).Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis.CHINESE JOURNAL OF NATURAL MEDICINES,12(9),700-704.
MLA Liu Li-Jia,et al."Absorption properties and mechanism of trolline and veratric acid and their implication to an evaluation of the effective components of the flowers of Trollius chinensis".CHINESE JOURNAL OF NATURAL MEDICINES 12.9(2014):700-704.
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