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学科主题临床医学
Pattern and risk factors of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: A large Chinese center experience
Fang, Dong; Xiong, Geng-Yan; Li, Xue-Song; Chen, Xiao-Peng; Zhang, Lei; Yao, Lin; He, Zhi-Song; Zhou, Li-Qun
关键词bladder tumor nephroureterectomy recurrence risk factors upper tract urothelial carcinoma (UTUC)
刊名JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION
2014-11-01
DOI10.1016/j.jfma.2013.11.004
113期:11页:820-827
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, General & Internal
研究领域[WOS]General & Internal Medicine
关键词[WOS]UPPER URINARY-TRACT ; TRANSITIONAL-CELL-CARCINOMA ; BLADDER RECURRENCE ; CANCER ; CHEMOTHERAPY ; MANAGEMENT ; RESECTION ; ORIGIN ; TUMORS
英文摘要

Background/purpose: There is currently no consensus about the pattern and risk factors of bladder recurrence after nephroureterectomy, especially in the Chinese population. We evaluated the pattern and risk factors based on data from a large Chinese center.

Methods: The clinical and pathological data of 438 patients with upper tract urothelial carcinoma (UTUC), who underwent nephroureterectomy at Peking University First Hospital, Beijing, China between 2000 and 2010, was retrospectively analyzed. Univariate analysis by log-rank test and multivariate analysis by Cox proportional hazards regression model were used to determine the independent risk factors.

Results: A total of 135 patients (30.8%) developed intravesical recurrence within a median follow-up of 45 months (range: 12-144 months). The median interval of bladder recurrence was 15 months (range: 2.0-98.0 months), and the two peaks for recurrence were 4-6 months and 17-19 months. Lower tumor grade, tumor multifocality, concomitant carcinoma in situ (CIS) and tumors located in the lower ureter were significant risk factors by univariate and multivariate analysis. A risk-scoring system was developed and a significant difference was found between different risk evaluations. Patients with concomitant CIS tended to develop a late bladder recurrence. One hundred and eighteen patients (87.4%) received transurethral resection after bladder tumor recurrence.

Conclusion: Lower tumor grade, tumor multifocality, concomitant CIS and tumors located in the lower ureter tend to be predictive for bladder recurrence after nephroureterectomy, although the underlying mechanism is not fully elucidated, and the scoring system could help risk stratification. Most recurrent tumors could be treated by transurethral resection and there were two peaks for recurrence, which is probably related to the mechanisms and may be unique to the Chinese population. Copyright (C) 2013, Elsevier Taiwan LLC & Formosan Medical Association. All rights reserved.

语种英语
WOS记录号WOS:000345557100007
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66663
专题北京大学第一临床医学院_泌尿外科
作者单位Peking Univ, Hosp 1, Natl Urol Canc Ctr, Inst Urol,Dept Urol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Fang, Dong,Xiong, Geng-Yan,Li, Xue-Song,et al. Pattern and risk factors of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: A large Chinese center experience[J]. JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION,2014,113(11):820-827.
APA Fang, Dong.,Xiong, Geng-Yan.,Li, Xue-Song.,Chen, Xiao-Peng.,Zhang, Lei.,...&Zhou, Li-Qun.(2014).Pattern and risk factors of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: A large Chinese center experience.JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION,113(11),820-827.
MLA Fang, Dong,et al."Pattern and risk factors of intravesical recurrence after nephroureterectomy for upper tract urothelial carcinoma: A large Chinese center experience".JOURNAL OF THE FORMOSAN MEDICAL ASSOCIATION 113.11(2014):820-827.
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