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学科主题: 药学
题名:
Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells
作者: Shi, Tian-Xing1; Wang, Shu2; Zeng, Ke-Wu1; Tu, Peng-Fei1; Jiang, Yong1
关键词: Polygala tenuifolia ; Glycosides ; Absolute configuration ; NO inhibition
刊名: BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
发表日期: 2013-11-01
DOI: 10.1016/j.bmcl.2013.08.085
卷: 23, 期:21, 页:5904-5908
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]: Pharmacology & Pharmacy ; Chemistry
关键词[WOS]: O-GLYCOSIDES ; XANTHONES ; ROOTS ; IDENTIFICATION ; GLUCOSIDES ; NEOLIGNANS ; SIBIRICA ; ESTER ; NMR
英文摘要:

Five new phenolic glycosides, tenuisides A-E (1-5), and a new megastigmane glycoside, tenuiside F (6), along with seventeen known compounds (7-23) were isolated from the aerial parts of Polygala tenuifolia Willd. Their structures were established by detailed analysis of NMR and HRESIMS spectroscopic data, and the absolute configurations of compounds 5 and 6 were determined by CD spectra and in-NMR-tube Mosher′s method. The inhibitory effects of these compounds were evaluated on NO production in LPS-activated BV-2 microglia cells. Compound 17 showed the strongest activity, with an IC50 value of 7.4 mu M, while compounds 1, 8, 14, and 18 showed the moderate activities, with IC50 values of 16.2-38.5 mu M. And their primary structure-activity relationships (SARs) of NO inhibitory effects were also briefly discussed. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81222051 ; 2012ZX09301002-002-002 ; 2012ZX09304-005
项目资助者: National Science Fund for Excellent Young Scholars ; National Key Technology R&amp ; D Program &prime ; New Drug Innovation&prime ; of China
WOS记录号: WOS:000325483000030
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66664
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Peoples Armed Police Forces, Logist Coll, Dept Med Chem & Pharmaceut Anal, Tianjin 300162, Peoples R China

Recommended Citation:
Shi, Tian-Xing,Wang, Shu,Zeng, Ke-Wu,et al. Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(21):5904-5908.
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