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Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells
Shi, Tian-Xing1; Wang, Shu2; Zeng, Ke-Wu1; Tu, Peng-Fei1; Jiang, Yong1
关键词Polygala tenuifolia Glycosides Absolute configuration NO inhibition
刊名BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
2013-11-01
DOI10.1016/j.bmcl.2013.08.085
23期:21页:5904-5908
收录类别SCI ; IC
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Chemistry, Organic
研究领域[WOS]Pharmacology & Pharmacy ; Chemistry
关键词[WOS]O-GLYCOSIDES ; XANTHONES ; ROOTS ; IDENTIFICATION ; GLUCOSIDES ; NEOLIGNANS ; SIBIRICA ; ESTER ; NMR
英文摘要

Five new phenolic glycosides, tenuisides A-E (1-5), and a new megastigmane glycoside, tenuiside F (6), along with seventeen known compounds (7-23) were isolated from the aerial parts of Polygala tenuifolia Willd. Their structures were established by detailed analysis of NMR and HRESIMS spectroscopic data, and the absolute configurations of compounds 5 and 6 were determined by CD spectra and in-NMR-tube Mosher′s method. The inhibitory effects of these compounds were evaluated on NO production in LPS-activated BV-2 microglia cells. Compound 17 showed the strongest activity, with an IC50 value of 7.4 mu M, while compounds 1, 8, 14, and 18 showed the moderate activities, with IC50 values of 16.2-38.5 mu M. And their primary structure-activity relationships (SARs) of NO inhibitory effects were also briefly discussed. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000325483000030
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66664
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
2.Chinese Peoples Armed Police Forces, Logist Coll, Dept Med Chem & Pharmaceut Anal, Tianjin 300162, Peoples R China
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Shi, Tian-Xing,Wang, Shu,Zeng, Ke-Wu,et al. Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2013,23(21):5904-5908.
APA Shi, Tian-Xing,Wang, Shu,Zeng, Ke-Wu,Tu, Peng-Fei,&Jiang, Yong.(2013).Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,23(21),5904-5908.
MLA Shi, Tian-Xing,et al."Inhibitory constituents from the aerial parts of Polygala tenuifolia on LPS-induced NO production in BV2 microglia cells".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 23.21(2013):5904-5908.
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