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Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice
He, Yue-Ying; Zhang, Bao-Xu; Jia, Feng-Lan
关键词2,4-dihydroxybenzophenone Acetaminophen Hepatotoxicity
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2011-06-07
DOI10.3748/wjg.v17.i21.2663
17期:21页:2663-2666
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
资助者Drug Innovation Program of National Science and Technology Project ; Drug Innovation Program of National Science and Technology Project
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]GLUTATHIONE ; MECHANISMS
英文摘要

AIM: To examine the effects of 2,4-dihydroxybenzophenone (BP-1), a benzophenone derivative used as an ultraviolet light absorbent, on acetaminophen (APAP)induced hepatotoxicity in C57BL/63 mice.

METHODS: Mice were administered orally with BP-1 at doses of 200, 400 and 800 mg/kg body weight respectively every morning for 4 d before a hepatotoxic dose of APAP (350 mg/kg body weight) was given subcutaneously. Twenty four hours after APAP intoxication, the serum enzyme including serum alaine aminotransferase (ALT), aspartate aminotransferase (AST), lactate dehydrogenase (LDH) were measured and liver histopathologic changes were examined.

RESULTS: BP-1 administration dramatically reduced serum ALT, AST and LDH levels. Liver histopathological examination showed that BP-1 administration antagonized APAP-induced liver pathological damage in a dose-dependent manner. Further tests showed that APAP-induced hepatic lipid peroxidation was reduced significantly by BP-1 pretreatment, and glutathione depletion was ameliorated obviously.

CONCLUSION: BP-1 can effectively protect C57BL/6J mice from APAP-induced hepatotoxicity, and reduction of oxidative stress might be part of the protection mechanism. (C) 2011 Baishideng. All rights reserved.

语种英语
所属项目编号2009ZX09103-007
资助者Drug Innovation Program of National Science and Technology Project ; Drug Innovation Program of National Science and Technology Project
WOS记录号WOS:000291618900014
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66672
专题北京大学公共卫生学院_毒理学系
作者单位Peking Univ, Sch Publ Hlth, Dept Toxicol, Beijing 100191, Peoples R China
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He, Yue-Ying,Zhang, Bao-Xu,Jia, Feng-Lan. Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2011,17(21):2663-2666.
APA He, Yue-Ying,Zhang, Bao-Xu,&Jia, Feng-Lan.(2011).Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice.WORLD JOURNAL OF GASTROENTEROLOGY,17(21),2663-2666.
MLA He, Yue-Ying,et al."Protective effects of 2,4-dihydroxybenzophenone against acetaminophen-induced hepatotoxicity in mice".WORLD JOURNAL OF GASTROENTEROLOGY 17.21(2011):2663-2666.
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