学科主题 | 公共卫生 |
Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study | |
Lai, Chin-Chih1,2; Sun, Dianjianyi1,3; Cen, Ruiqi1; Wang, Jian4; Li, Shengxu1; Fernandez-Alonso, Camilo1; Chen, Wei1; Srinivasan, Sathanur R.1; Berenson, Gerald S.1 | |
关键词 | adiposity blood pressure geometric remodeling left ventricular hypertrophy longitudinal analysis |
刊名 | JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
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2014-10-14 | |
DOI | 10.1016/j.jacc.2014.05.072 |
卷 | 64期:15页:1580-1587 |
收录类别 | SCI |
文章类型 | Article |
WOS标题词 | Science & Technology |
类目[WOS] | Cardiac & Cardiovascular Systems |
资助者 | National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association ; National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association |
研究领域[WOS] | Cardiovascular System & Cardiology |
关键词[WOS] | AUTOSOMAL GENOME SCAN ; BODY-MASS INDEX ; ESSENTIAL-HYPERTENSION ; YOUNG-ADULTS ; RISK-FACTORS ; HYPERTROPHY ; OBESITY ; GEOMETRY ; CHILDREN ; CARDIA |
英文摘要 | BACKGROUND Cardiovascular risk factors are associated with left ventricular hypertrophy (LVH), but little is known regarding related impact of longitudinal measures of childhood adiposity and LV hemodynamic variables. OBJECTIVES The aim of this study was to examine the impact of cumulative long-term burden and trends of excessive adiposity and elevated blood pressure (BP) during childhood on adulthood LVH and LV geometric remodeling patterns. METHODS This longitudinal study consisted of 1,061 adults, age 24 to 46 years, who had been examined 4 or more times for body mass index (BMI) and BP starting in childhood, with a mean follow-up of 28.0 years. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI and BP from childhood to adulthood. Four LV geometric types were defined-normal, concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH)-all on the basis of LV mass indexed for body height (m(2.7)) and relative wall thickness. RESULTS Higher values of BMI and systolic and diastolic BP in childhood and adulthood, as well as total AUC and incremental AUC, were all significantly associated with higher LV mass index and LVH, adjusted for race, sex, and age. In addition, higher values of BMI and BP in childhood and adulthood, total AUC, and incremental AUC were significantly associated with EH and CH but not with CR. Importantly, all of these measures of BMI had a consistently and significantly greater influence on EH than did measures of BP. CONCLUSIONS These findings indicate that the adverse influence of excessive adiposity and elevated BP levels on LVH begins in childhood. |
语种 | 英语 |
所属项目编号 | R01ES021724 ; R01AG016592 ; 13SDG14650068 |
资助者 | National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association ; National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association |
WOS记录号 | WOS:000343470400007 |
Citation statistics | |
文献类型 | 期刊论文 |
条目标识符 | http://ir.bjmu.edu.cn/handle/400002259/66675 |
Collection | 北京大学公共卫生学院 |
作者单位 | 1.Beijing Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China 2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China 3.Shanxi Med Univ, Affiliated Hosp 1, Taiyuan, Peoples R China 4.Tulane Univ, Dept Epidemiol, New Orleans, LA 70118 USA |
Recommended Citation GB/T 7714 | Lai, Chin-Chih,Sun, Dianjianyi,Cen, Ruiqi,et al. Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2014,64(15):1580-1587. |
APA | Lai, Chin-Chih.,Sun, Dianjianyi.,Cen, Ruiqi.,Wang, Jian.,Li, Shengxu.,...&Berenson, Gerald S..(2014).Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,64(15),1580-1587. |
MLA | Lai, Chin-Chih,et al."Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 64.15(2014):1580-1587. |
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