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Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study
Lai, Chin-Chih1,2; Sun, Dianjianyi1,3; Cen, Ruiqi1; Wang, Jian4; Li, Shengxu1; Fernandez-Alonso, Camilo1; Chen, Wei1; Srinivasan, Sathanur R.1; Berenson, Gerald S.1
关键词adiposity blood pressure geometric remodeling left ventricular hypertrophy longitudinal analysis
刊名JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
2014-10-14
DOI10.1016/j.jacc.2014.05.072
64期:15页:1580-1587
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]AUTOSOMAL GENOME SCAN ; BODY-MASS INDEX ; ESSENTIAL-HYPERTENSION ; YOUNG-ADULTS ; RISK-FACTORS ; HYPERTROPHY ; OBESITY ; GEOMETRY ; CHILDREN ; CARDIA
英文摘要

BACKGROUND Cardiovascular risk factors are associated with left ventricular hypertrophy (LVH), but little is known regarding related impact of longitudinal measures of childhood adiposity and LV hemodynamic variables.

OBJECTIVES The aim of this study was to examine the impact of cumulative long-term burden and trends of excessive adiposity and elevated blood pressure (BP) during childhood on adulthood LVH and LV geometric remodeling patterns.

METHODS This longitudinal study consisted of 1,061 adults, age 24 to 46 years, who had been examined 4 or more times for body mass index (BMI) and BP starting in childhood, with a mean follow-up of 28.0 years. The area under the curve (AUC) was calculated as a measure of long-term burden (total AUC) and trends (incremental AUC) of BMI and BP from childhood to adulthood. Four LV geometric types were defined-normal, concentric remodeling (CR), eccentric hypertrophy (EH), and concentric hypertrophy (CH)-all on the basis of LV mass indexed for body height (m(2.7)) and relative wall thickness.

RESULTS Higher values of BMI and systolic and diastolic BP in childhood and adulthood, as well as total AUC and incremental AUC, were all significantly associated with higher LV mass index and LVH, adjusted for race, sex, and age. In addition, higher values of BMI and BP in childhood and adulthood, total AUC, and incremental AUC were significantly associated with EH and CH but not with CR. Importantly, all of these measures of BMI had a consistently and significantly greater influence on EH than did measures of BP.

CONCLUSIONS These findings indicate that the adverse influence of excessive adiposity and elevated BP levels on LVH begins in childhood.

语种英语
WOS记录号WOS:000343470400007
项目编号R01ES021724 ; R01AG016592 ; 13SDG14650068
资助机构National Institute of Environmental Health Science ; National Institute on Aging ; American Heart Association
引用统计
被引频次:51[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66675
专题北京大学公共卫生学院
作者单位1.Beijing Union Med Coll Hosp, Dept Cardiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
3.Shanxi Med Univ, Affiliated Hosp 1, Taiyuan, Peoples R China
4.Tulane Univ, Dept Epidemiol, New Orleans, LA 70118 USA
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Lai, Chin-Chih,Sun, Dianjianyi,Cen, Ruiqi,et al. Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study[J]. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,2014,64(15):1580-1587.
APA Lai, Chin-Chih.,Sun, Dianjianyi.,Cen, Ruiqi.,Wang, Jian.,Li, Shengxu.,...&Berenson, Gerald S..(2014).Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study.JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY,64(15),1580-1587.
MLA Lai, Chin-Chih,et al."Impact of Long-Term Burden of Excessive Adiposity and Elevated Blood Pressure From Childhood on Adulthood Left Ventricular Remodeling Patterns The Bogalusa Heart Study".JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY 64.15(2014):1580-1587.
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