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学科主题: 药学
题名:
Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs
作者: Zhang, Liangren1; Yang, Zhenjun1; Guse, Andreas H.2; Zhang, Lihe1
关键词: cADPR analogs ; agonists ; nucleotides ; synthesis ; signal messengers
刊名: PURE AND APPLIED CHEMISTRY
发表日期: 2008-08-01
DOI: 10.1351/pac200880081821
卷: 80, 期:8, 页:1821-1825
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: RELEASE ACTIVITY ; CARBOCYCLIC-RIBOSE ; NORTHERN RIBOSE ; DERIVATIVES ; POTENT ; DIPHOSPHORIBOSE ; MOIETY ; MIMICS ; CELLS
英文摘要:

A series of cyclic ADP-ribose (cADPR) analogs, in which modifications mainly focused on riboses, was synthesized in order to explore the molecular mechanism Of calcium release regulated by cADPR. Biological activities investigated in intact T-lymphocytes showed that the structurally simplified analogs, NI-ethoxyrnethyl-substituted cyclic inosine diphosphoribose (cIDPRE), N1,N9-diethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPDE), and N1-ethoxymethil-substituted cyclic adenosine diphosphoribose (cADPRE) in which the northern ribose or both northern and southern riboses were replaced by ether linkages are membrane-permeant and induce calcium release from intracellular stores. This research has provided novel molecules to probe cADPR-mediated calcium signaling and enlarges Our knowledge of the structure-activity relationships of cADPR analogs.

语种: 英语
WOS记录号: WOS:000258562000019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66676
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Hosp Hamburg Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol I Cellular Signal Transdu, D-20246 Hamburg, Germany

Recommended Citation:
Zhang, Liangren,Yang, Zhenjun,Guse, Andreas H.,et al. Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs[J]. PURE AND APPLIED CHEMISTRY,2008,80(8):1821-1825.
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