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Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs
Zhang, Liangren1; Yang, Zhenjun1; Guse, Andreas H.2; Zhang, Lihe1
关键词cADPR analogs agonists nucleotides synthesis signal messengers
刊名PURE AND APPLIED CHEMISTRY
2008-08-01
DOI10.1351/pac200880081821
80期:8页:1821-1825
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]RELEASE ACTIVITY ; CARBOCYCLIC-RIBOSE ; NORTHERN RIBOSE ; DERIVATIVES ; POTENT ; DIPHOSPHORIBOSE ; MOIETY ; MIMICS ; CELLS
英文摘要

A series of cyclic ADP-ribose (cADPR) analogs, in which modifications mainly focused on riboses, was synthesized in order to explore the molecular mechanism Of calcium release regulated by cADPR. Biological activities investigated in intact T-lymphocytes showed that the structurally simplified analogs, NI-ethoxyrnethyl-substituted cyclic inosine diphosphoribose (cIDPRE), N1,N9-diethoxymethyl-substituted cyclic inosine diphosphoribose (cIDPDE), and N1-ethoxymethil-substituted cyclic adenosine diphosphoribose (cADPRE) in which the northern ribose or both northern and southern riboses were replaced by ether linkages are membrane-permeant and induce calcium release from intracellular stores. This research has provided novel molecules to probe cADPR-mediated calcium signaling and enlarges Our knowledge of the structure-activity relationships of cADPR analogs.

语种英语
WOS记录号WOS:000258562000019
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66676
专题北京大学药学院
北京大学药学院_药物化学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China
2.Univ Hosp Hamburg Eppendorf, Ctr Med Expt, Inst Biochem & Mol Biol I Cellular Signal Transdu, D-20246 Hamburg, Germany
推荐引用方式
GB/T 7714
Zhang, Liangren,Yang, Zhenjun,Guse, Andreas H.,et al. Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs[J]. PURE AND APPLIED CHEMISTRY,2008,80(8):1821-1825.
APA Zhang, Liangren,Yang, Zhenjun,Guse, Andreas H.,&Zhang, Lihe.(2008).Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs.PURE AND APPLIED CHEMISTRY,80(8),1821-1825.
MLA Zhang, Liangren,et al."Adenine-based calcium signal pathway messengers: Synthesis and agonistic properties of cyclic ADP-ribose analogs".PURE AND APPLIED CHEMISTRY 80.8(2008):1821-1825.
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