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Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo
Huang, Yue1; Chen, Xiao-Mei1; Zhao, Bing-Xiang1; Ke, Xi-Yu1; Zhao, Bo-Jun1; Zhao, Xin1; Wang, Ying1; Zhang, Xuan1; Zhang, Qiang1,2
关键词antiangiogenic activity migration paclitaxel proliferation sterically stabilized liposomes
刊名AAPS PHARMSCITECH
2010-06-01
DOI10.1208/s12249-010-9430-z
11期:2页:752-759
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pharmacology & Pharmacy
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]ALBUMIN-BOUND PACLITAXEL ; HUMAN TUMOR XENOGRAFT ; CATIONIC LIPOSOMES ; BREAST-CANCER ; METRONOMIC CHEMOTHERAPY ; CREMOPHOR EL ; DRUG-DELIVERY ; FORMULATION ; EFFICACY ; INHIBITION
英文摘要

The purpose of this present study was to evaluate the antiangiogenic activity of sterically stabilized liposomes containing paclitaxel (SSL-PTX). The SSL-PTX was prepared by the thin-film method. The release of paclitaxel from SSL-PTX was analyzed using a dialysis method. The effect of SSL-PTX on endothelial cell proliferation and migration was investigated in vitro. The antitumor and antiangiogenic activity of SSL-PTX was evaluated in MDA-MB-231 tumor xenograft growth in BALB/c nude mice. The release of paclitaxel from SSL-PTX was 22% within 24 h. Our in vitro results indicated that SSL-PTX could effectively inhibit the endothelial cell proliferation and migration at a concentration-dependent manner. We also observed that metronomic SSL-PTX induced marked tumor growth inhibition in MDA-MB-231 xenograft model via the antiangiogenic mechanism, unlike that in paclitaxel injection (Taxol) formulated in Cremophor EL (CrEL). Overall, our results suggested that metronomic chemotherapy with low-dose, CrEL-free SSL-PTX should be feasible and effective.

语种英语
所属项目编号30873170 ; 2007CB935800 ; 2009CB930300
资助者National Natural Science Foundation of China ; National Basic Research Program of China (973 Program) ; National Natural Science Foundation of China ; National Basic Research Program of China (973 Program)
WOS记录号WOS:000278921400031
引用统计
被引频次:18[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66688
专题北京大学药学院_药剂学系
作者单位1.Peking Univ, Dept Pharmaceut, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
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GB/T 7714
Huang, Yue,Chen, Xiao-Mei,Zhao, Bing-Xiang,et al. Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo[J]. AAPS PHARMSCITECH,2010,11(2):752-759.
APA Huang, Yue.,Chen, Xiao-Mei.,Zhao, Bing-Xiang.,Ke, Xi-Yu.,Zhao, Bo-Jun.,...&Zhang, Qiang.(2010).Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo.AAPS PHARMSCITECH,11(2),752-759.
MLA Huang, Yue,et al."Antiangiogenic Activity of Sterically Stabilized Liposomes Containing Paclitaxel (SSL-PTX): In Vitro and In Vivo".AAPS PHARMSCITECH 11.2(2010):752-759.
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