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学科主题: 药物依赖
题名:
Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy
作者: Sun, Hongqiang2,3; Guo, Song1,4; Chen, Dafang5; Yang, Fude2; Zou, Yizhuang2; Di, Xiaolan2; Cao, Yanjun2; Kosten, Thomas6; Lu, Lin3; Zhang, Xiang Yang2,6,7
关键词: Pharmacogenetics ; COMT ; Nicotine dependence ; Smoking ; Dopamine
刊名: JOURNAL OF NEURAL TRANSMISSION
发表日期: 2012-12-01
DOI: 10.1007/s00702-012-0841-8
卷: 119, 期:12, 页:1491-1498
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CATECHOL-O-METHYLTRANSFERASE ; GENETIC-VARIATION ; CONTROLLED TRIAL ; CHINESE SMOKERS ; DOUBLE-BLIND ; DEPENDENCE ; GENOTYPE ; PHARMACOGENETICS ; INHIBITORS ; INITIATION
英文摘要:

Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. We evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial among Chinese smokers. We conducted a double-blind, placebo-controlled, 8-week trial of SNT with a follow-up at week 12 among 250 Chinese smokers. Efficacy and safety were evaluated at day 4 and weeks 2, 4, 6, 8, and 12. Abstinence was biochemically verified by exhaled carbon monoxide (CO) and urine cotinine. The COMT Val108Met genotype was determined as a restriction fragment length polymorphism. Our results showed that the success rates for complete abstinence were greater for active versus placebo treatments at 8 weeks (48 vs. 17 %) and 12 weeks (52 vs. 19 %) (both p < 0.0001). Craving was significantly reduced from week 2 on active treatment compared to placebo. Adverse events were mild and tolerable. We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). We found that SNT significantly increased smoking abstinence, reduced craving and was well tolerated, and the COMT Val/Val genotype was associated with a greater improvement in smoking cessation.

语种: 英语
所属项目编号: 81071080 ; 2010D003034000026 ; 03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
项目资助者: National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China ; Stanley Medical research Institute ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health
WOS记录号: WOS:000311509900005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66689
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Capital Univ Med Sci, Beijing Anding Hosp, Natl Drug Abuse Treatment Ctr, Beijing 100009, Peoples R China
2.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
4.Inst Mental Hlth, Addict Med Dept, Singapore, Singapore
5.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
6.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
7.VA Med Ctr, Houston, TX 77030 USA

Recommended Citation:
Sun, Hongqiang,Guo, Song,Chen, Dafang,et al. Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy[J]. JOURNAL OF NEURAL TRANSMISSION,2012,119(12):1491-1498.
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