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Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy
Sun, Hongqiang2,3; Guo, Song1,4; Chen, Dafang5; Yang, Fude2; Zou, Yizhuang2; Di, Xiaolan2; Cao, Yanjun2; Kosten, Thomas6; Lu, Lin3; Zhang, Xiang Yang2,6,7
关键词Pharmacogenetics COMT Nicotine dependence Smoking Dopamine
刊名JOURNAL OF NEURAL TRANSMISSION
2012-12-01
DOI10.1007/s00702-012-0841-8
119期:12页:1491-1498
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]CATECHOL-O-METHYLTRANSFERASE ; GENETIC-VARIATION ; CONTROLLED TRIAL ; CHINESE SMOKERS ; DOUBLE-BLIND ; DEPENDENCE ; GENOTYPE ; PHARMACOGENETICS ; INHIBITORS ; INITIATION
英文摘要

Nicotine replacement treatment (NRT) can be efficacious for smoking cessation, but used by only a minority of smokers in China. Pharmacogenetic matching may improve treatment outcomes for NRT in subgroups of smokers. We evaluated the efficacy and safety of sublingual nicotine tablets (SNT) for smoking cessation and the association of catechol-O-methyltransferase (COMT) genotype with efficacy in this smoking cessation trial among Chinese smokers. We conducted a double-blind, placebo-controlled, 8-week trial of SNT with a follow-up at week 12 among 250 Chinese smokers. Efficacy and safety were evaluated at day 4 and weeks 2, 4, 6, 8, and 12. Abstinence was biochemically verified by exhaled carbon monoxide (CO) and urine cotinine. The COMT Val108Met genotype was determined as a restriction fragment length polymorphism. Our results showed that the success rates for complete abstinence were greater for active versus placebo treatments at 8 weeks (48 vs. 17 %) and 12 weeks (52 vs. 19 %) (both p < 0.0001). Craving was significantly reduced from week 2 on active treatment compared to placebo. Adverse events were mild and tolerable. We found a genotype by treatment interaction at 12 weeks with greater abstinence rates in the COMT Val/Val (50 vs. 15 %) than the Met/Val + Met/Met genotypes (46 vs. 25 %). We found that SNT significantly increased smoking abstinence, reduced craving and was well tolerated, and the COMT Val/Val genotype was associated with a greater improvement in smoking cessation.

语种英语
WOS记录号WOS:000311509900005
项目编号81071080 ; 2010D003034000026 ; 03T-459 ; 05T-726 ; K05-DA0454 ; P50-DA18827 ; U01-MH79639
资助机构National Natural Science Foundation of China ; Training Program Foundation for Excellent Talents by the Beijing Municipal Government, China ; Stanley Medical research Institute ; Department of Veterans Affairs, VISN 16, Mental Illness Research, Education and Clinical Center (MIRECC), United States National Institute of Health
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66689
专题中国药物依赖性研究所
北京大学基础医学院
北京大学精神卫生研究所_精神科
作者单位1.Capital Univ Med Sci, Beijing Anding Hosp, Natl Drug Abuse Treatment Ctr, Beijing 100009, Peoples R China
2.Beijing Hui Long Guan Hosp, Beijing, Peoples R China
3.Peking Univ, Natl Inst Drug Dependence, Beijing 100871, Peoples R China
4.Inst Mental Hlth, Addict Med Dept, Singapore, Singapore
5.Peking Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Beijing 100871, Peoples R China
6.Baylor Coll Med, Dept Psychiat & Behav Sci, Houston, TX 77030 USA
7.VA Med Ctr, Houston, TX 77030 USA
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GB/T 7714
Sun, Hongqiang,Guo, Song,Chen, Dafang,et al. Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy[J]. JOURNAL OF NEURAL TRANSMISSION,2012,119(12):1491-1498.
APA Sun, Hongqiang.,Guo, Song.,Chen, Dafang.,Yang, Fude.,Zou, Yizhuang.,...&Zhang, Xiang Yang.(2012).Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy.JOURNAL OF NEURAL TRANSMISSION,119(12),1491-1498.
MLA Sun, Hongqiang,et al."Association of functional COMT Val108/Met polymorphism with smoking cessation in a nicotine replacement therapy".JOURNAL OF NEURAL TRANSMISSION 119.12(2012):1491-1498.
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