学科主题基础医学
Molecular pathology in the lungs of severe acute respiratory syndrome patients
Ye, Juxiang; Zhang, Bo; Xu, Jian; Chang, Qing; McNutt, Michael A.; Korteweg, Christine; Gong, Encong; Gu, Jiang
刊名AMERICAN JOURNAL OF PATHOLOGY
2007-02-01
DOI10.2353/ajpath.2007.060469
170期:2页:538-545
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pathology
研究领域[WOS]Pathology
关键词[WOS]SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; FUNCTIONAL RECEPTOR ; DC-SIGN ; DENDRITIC CELL ; CATHEPSIN-L ; PATHOGENESIS ; PROTEIN ; GLYCOPROTEIN ; VIRUS
英文摘要

Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. in addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in sAlts.

语种英语
WOS记录号WOS:000243951000013
引用统计
被引频次:30[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66692
专题北京大学基础医学院_北京大学感染病研究中心
作者单位1.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Dept Pathol,Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Histol & Embryol, Beijing 100871, Peoples R China
3.SUNY Hlth Sci Ctr, Dept Pathol, Brooklyn, NY 11203 USA
推荐引用方式
GB/T 7714
Ye, Juxiang,Zhang, Bo,Xu, Jian,et al. Molecular pathology in the lungs of severe acute respiratory syndrome patients[J]. AMERICAN JOURNAL OF PATHOLOGY,2007,170(2):538-545.
APA Ye, Juxiang.,Zhang, Bo.,Xu, Jian.,Chang, Qing.,McNutt, Michael A..,...&Gu, Jiang.(2007).Molecular pathology in the lungs of severe acute respiratory syndrome patients.AMERICAN JOURNAL OF PATHOLOGY,170(2),538-545.
MLA Ye, Juxiang,et al."Molecular pathology in the lungs of severe acute respiratory syndrome patients".AMERICAN JOURNAL OF PATHOLOGY 170.2(2007):538-545.
条目包含的文件 下载所有文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
Molecular pathology (600KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 下载
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Ye, Juxiang]的文章
[Zhang, Bo]的文章
[Xu, Jian]的文章
百度学术
百度学术中相似的文章
[Ye, Juxiang]的文章
[Zhang, Bo]的文章
[Xu, Jian]的文章
必应学术
必应学术中相似的文章
[Ye, Juxiang]的文章
[Zhang, Bo]的文章
[Xu, Jian]的文章
相关权益政策
暂无数据
收藏/分享
文件名: Molecular pathology in the lungs of severe acute respiratory syndrome patients.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。