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学科主题: 基础医学
题名:
Molecular pathology in the lungs of severe acute respiratory syndrome patients
作者: Ye, Juxiang; Zhang, Bo; Xu, Jian; Chang, Qing; McNutt, Michael A.; Korteweg, Christine; Gong, Encong; Gu, Jiang
刊名: AMERICAN JOURNAL OF PATHOLOGY
发表日期: 2007-02-01
DOI: 10.2353/ajpath.2007.060469
卷: 170, 期:2, 页:538-545
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pathology
研究领域[WOS]: Pathology
关键词[WOS]: SARS-ASSOCIATED CORONAVIRUS ; IN-SITU HYBRIDIZATION ; FUNCTIONAL RECEPTOR ; DC-SIGN ; DENDRITIC CELL ; CATHEPSIN-L ; PATHOGENESIS ; PROTEIN ; GLYCOPROTEIN ; VIRUS
英文摘要:

Severe acute respiratory syndrome (SARS) is a novel infectious disease with disastrous clinical consequences, in which the lungs are the major target organs. Previous studies have described the general pathology in the lungs of SARS patients and have identified some of the cell types infected by SARS coronavirus (SARS-CoV). However, at the time of this writing, there were no comprehensive reports of the cellular distribution of the virus in lung tissue. In this study, we have performed double labeling combining in situ hybridization with immunohistochemistry and alternating each of these techniques separately in consecutive sections to evaluate the viral distribution on various cell types in the lungs of seven patients affected with SARS. We found that SARS-CoV was present in bronchial epithelium, type I and II pneumocytes, T lymphocytes, and macrophages/monocytes. For pneumocytes, T lymphocytes, and macrophages, the infection rates were calculated. in addition, our present study is the first to demonstrate infection of endothelial cells and fibroblasts in sAlts.

语种: 英语
WOS记录号: WOS:000243951000013
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66692
Appears in Collections:基础医学院_北京大学感染病研究中心_期刊论文

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作者单位: 1.Peking Univ, Ctr Infect Dis, Sch Basic Med Sci, Dept Pathol,Hlth Sci Ctr, Beijing 100083, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Histol & Embryol, Beijing 100871, Peoples R China
3.SUNY Hlth Sci Ctr, Dept Pathol, Brooklyn, NY 11203 USA

Recommended Citation:
Ye, Juxiang,Zhang, Bo,Xu, Jian,et al. Molecular pathology in the lungs of severe acute respiratory syndrome patients[J]. AMERICAN JOURNAL OF PATHOLOGY,2007,170(2):538-545.
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