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Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents
Yan, Hao1,2,3; Tian, Lin1,2,3; Wang, Qifeng4; Zhao, Qiang5; Yue, Weihua1,2,3; Yan, Jun1,2,3; Liu, Bing4; Zhang, Dai1,2,3,6,7
关键词network analysis diffusion tensor imaging tractography white matter small-world architecture
刊名NEUROSCIENCE BULLETIN
2015-06-01
DOI10.1007/s12264-014-1518-0
31期:3页:275-287
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]GRAPH-THEORETICAL ANALYSIS ; HUMAN CEREBRAL-CORTEX ; WHITE-MATTER ; FUNCTIONAL NETWORKS ; CORTICAL NETWORKS ; FIBER INTEGRITY ; GENETIC RISK ; CONNECTIVITY ; RELATIVES ; SIBLINGS
英文摘要

Several lines of evidence suggest that efficient information integration between brain regions is disrupted in schizophrenia. Abnormalities in white matter tracts that interconnect brain regions may be directly relevant to this pathophysiological process. As a complex mental disorder with high heritability, mapping abnormalities in patients and their first-degree relatives may help to disentangle the risk factors for schizophrenia. We established a weighted network model of white matter connections using diffusion tensor imaging in 25 nuclear families with schizophrenic probands (19 patients and 41 unaffected parents) and two unrelated groups of normal controls (24 controls matched with patients and 26 controls matched with relatives). The patient group showed lower global efficiency and local efficiency. The decreased regional efficiency was localized in hubs such as the bilateral frontal cortices, bilateral anterior cingulate cortices, and left precuneus. The global efficiency was negatively correlated with cognition scores derived from a 5-factor model of schizophrenic psychopathology. We also found that unaffected parents displayed decreased regional efficiency in the right temporal cortices, left supplementary motor area, left superior temporal pole, and left thalamus. The global efficiency tended to be lower in unaffected parents. Our data suggest that (1) the global efficiency loss in neuroanatomical networks may be associated with the cognitive disturbances in schizophrenia; and (2) genetic vulnerability to schizophrenia may influence the anatomical organization of an individual′s brain networks.

语种英语
WOS记录号WOS:000355619700001
项目编号2011CB707805 ; 81370032 ; 91232305 ; 81361120395 ; 91432304 ; 2010DFB30820
资助机构National Basic Research Program of China ; National Natural Science Foundation of China ; International Science &amp ; Technology Cooperation Program of China
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66696
专题北京大学精神卫生研究所
北京大学第一临床医学院_妇产科
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Hosp 6, Beijing 100191, Peoples R China
2.Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China
3.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100191, Peoples R China
4.Chinese Acad Sci, Inst Automat, Natl Lab Pattern Recognit, LIAMA Ctr Computat Med, Beijing 100190, Peoples R China
5.Peking Univ, Hosp 3, Dept Radiol, Beijing 100191, Peoples R China
6.Peking Tsinghua Ctr Life Sci, Beijing 100871, Peoples R China
7.Peking Univ, PKU IDG McGovern Inst Brain Res, Beijing 100871, Peoples R China
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GB/T 7714
Yan, Hao,Tian, Lin,Wang, Qifeng,et al. Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents[J]. NEUROSCIENCE BULLETIN,2015,31(3):275-287.
APA Yan, Hao.,Tian, Lin.,Wang, Qifeng.,Zhao, Qiang.,Yue, Weihua.,...&Zhang, Dai.(2015).Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents.NEUROSCIENCE BULLETIN,31(3),275-287.
MLA Yan, Hao,et al."Compromised small-world efficiency of structural brain networks in schizophrenic patients and their unaffected parents".NEUROSCIENCE BULLETIN 31.3(2015):275-287.
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