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学科主题临床医学
Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis
Zhang, Lei1; Yin, Wenshi1; Yao, Lin1; Li, Xuesong1; Fang, Dong1; Ren, Da1; Zhang, Zhongyuan1; Fan, Yu1; He, Qun1; Ci, Weimin2; He, Zhisong1; Zhou, Liqun1
刊名BIOMED RESEARCH INTERNATIONAL
2015
DOI10.1155/2015/598134
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biotechnology & Applied Microbiology ; Medicine, Research & Experimental
研究领域[WOS]Biotechnology & Applied Microbiology ; Research & Experimental Medicine
关键词[WOS]NATURAL-HISTORY ; ACTIVE SURVEILLANCE ; CONSERVATIVE MANAGEMENT ; PERCUTANEOUS BIOPSY ; HELICAL CT ; MASSES ; PROLIFERATION ; EXPERIENCE ; APOPTOSIS ; KINETICS
英文摘要

Objectives. Previous studies revealed an unclear correlation between the growth rate of renal cell carcinoma (RCC) and tumor grade and did not focus on certain histological subtype. This report investigated the correlation between the growth rate and tumor grade in clear cell RCC (ccRCC). Methods. We reviewed 60 patients with 61 ccRCC confirmed by delayed surgeries after at least 12 months of active surveillance. The linear growth rate (LGR), volumetric growth rate (VGR), and volume doubling time (VDT) were calculated, and their correlationswith clinicopathologic characteristics were analyzed. Results. The mean LGR, VGR, and VDT were 0.86 (range 0-4.74) cm/year, 20.96 (range 0.31-211.93) cm(3)/year, and 667 (range 33-3321) days, respectively. ccRCCs with high grade had greater LGR (P<0.001) and VGR (P = 0.001) and lower VDT (P = 0.017) than ccRCCs with low grade. Grade (OR = 5.185, P = 0.004) was the only independent risk factor of LGR > 0.5 cm/year, and grade (OR = 3.006, P = 0.046) and initial size (OR = 0.392, P = 0.004) were independent risk factors of VDT < 1 year. Five patients developed metastasis after surgery with LGR > 0.5 cm/yr altogether; of them, four had cancer-related death by the last follow-up. Conclusions. Fast growth rate of ccRCC is significantly correlated with high tumor grade and may result in poor prognosis, especially for those with LGR >0.5 cm/yr.

语种英语
WOS记录号WOS:000361208600001
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66697
专题北京大学第一临床医学院_泌尿外科
北京大学基础医学院
作者单位1.Peking Univ, Natl Urol Canc Ctr, Dept Urol, Hosp 1,Inst Urol, Beijing 100034, Peoples R China
2.Chinese Acad Sci, Beijing Inst Genom, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Lei,Yin, Wenshi,Yao, Lin,et al. Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis[J]. BIOMED RESEARCH INTERNATIONAL,2015.
APA Zhang, Lei.,Yin, Wenshi.,Yao, Lin.,Li, Xuesong.,Fang, Dong.,...&Zhou, Liqun.(2015).Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis.BIOMED RESEARCH INTERNATIONAL.
MLA Zhang, Lei,et al."Growth Pattern of Clear Cell Renal Cell Carcinoma in Patients with Delayed Surgical Intervention: Fast Growth Rate Correlates with High Grade and May Result in Poor Prognosis".BIOMED RESEARCH INTERNATIONAL (2015).
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