IR@PKUHSC  > 北京大学临床肿瘤学院
学科主题临床医学
A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation
Hu, Lelin1,2; Wang, Jiangnan1,2; Liu, Yun1,2; Zhang, Ying1,4; Zhang, Liangliang1,2; Kong, Ruirui1,4; Zheng, Zongfang1,4; Du, Xiaojuan1,2; Ke, Yang1,3,4
刊名JOURNAL OF BIOLOGICAL CHEMISTRY
2011-01-28
DOI10.1074/jbc.M110.157842
286期:4页:3119-3128
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]DNA-DAMAGE ; PROTEASOMAL DEGRADATION ; CELL-CYCLE ; RNA ; MDM2 ; INHIBITION ; PATHWAY ; BIOGENESIS ; RETROGENE ; DEPLETION
英文摘要

Ribosome biogenesis is required for normal cell function, and aberrant ribosome biogenesis can lead to p53 activation. However, how p53 is activated by defects of ribosome biogenesis remains to be determined. Here, we identified human UTP14a as an SSU processome component by showing that hUTP14a is nucleolar, associated with U3 snoRNA and involved in 18 S rRNA processing. Interestingly, ectopic expression of hUTP14a resulted in a decrease and knockdown of hUTP14a led to an increase of p53 protein levels. We showed that hUTP14a physically interacts with p53 and functionally promotes p53 turn-over, and that hUTP14a promotion of p53 destabilization is sensitive to a proteasome inhibitor but independent of ubiquitination. Significantly, knockdown of hUTP14a led to cell cycle arrest and apoptosis. Our data identified a novel pathway for p53 activation through a defect in rRNA processing and suggest that a ribosome biogenesis factor itself could act as a sensor for nucleolar stress to regulate p53.

语种英语
WOS记录号WOS:000286464300073
项目编号30571038 ; 30771224 ; 985-2-016-24 ; 2008AA02Z131 ; 2006AA02A402 ; 2010CB529303
资助机构National Natural Science Foundation of China ; Key Construction Program of the National "985" Project ; National High Technology Research and Development Program of China (863 Program) ; National Basic Research Program of China (973 Program)
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66698
专题北京大学临床肿瘤学院
北京大学医学部管理机构_医学部
北京大学基础医学院
北京大学临床肿瘤学院_遗传学研究室
作者单位1.Peking Univ, Hlth Sci Ctr, Canc Res Ctr, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Cell Biol, Beijing 100191, Peoples R China
3.Peking Univ, Sch Oncol, Genet Lab, Beijing Canc Hosp & Inst, Beijing 100142, Peoples R China
4.Peking Univ, Sch Oncol, Beijing Canc Hosp & Inst, Key Lab Carcinogenesis & Translat Res,Minist Educ, Beijing 100142, Peoples R China
推荐引用方式
GB/T 7714
Hu, Lelin,Wang, Jiangnan,Liu, Yun,et al. A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation[J]. JOURNAL OF BIOLOGICAL CHEMISTRY,2011,286(4):3119-3128.
APA Hu, Lelin.,Wang, Jiangnan.,Liu, Yun.,Zhang, Ying.,Zhang, Liangliang.,...&Ke, Yang.(2011).A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation.JOURNAL OF BIOLOGICAL CHEMISTRY,286(4),3119-3128.
MLA Hu, Lelin,et al."A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation".JOURNAL OF BIOLOGICAL CHEMISTRY 286.4(2011):3119-3128.
条目包含的文件
文件名称/大小 文献类型 版本类型 开放类型 使用许可
A Small Ribosomal Su(2062KB)期刊论文出版稿开放获取CC BY-NC-SA浏览 请求全文
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hu, Lelin]的文章
[Wang, Jiangnan]的文章
[Liu, Yun]的文章
百度学术
百度学术中相似的文章
[Hu, Lelin]的文章
[Wang, Jiangnan]的文章
[Liu, Yun]的文章
必应学术
必应学术中相似的文章
[Hu, Lelin]的文章
[Wang, Jiangnan]的文章
[Liu, Yun]的文章
相关权益政策
暂无数据
收藏/分享
文件名: A Small Ribosomal Subunit (SSU) Processome Component, the Human U3 Protein 14A (hUTP14A) Binds p53 and Promotes p53 Degradation.pdf
格式: Adobe PDF
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。