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学科主题: 临床医学
题名:
Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection
作者: Rao, Huiying1; Wei, Lai1; Carlos Lopez-Talavera, Juan30; Shang, Jia4; Chen, Hong6; Li, Jun7; Xie, Qing8; Gao, Zhiliang10; Wang, Lei12; Wei, Jia13; Jiang, Jianning14; Sun, Yongtao15; Yang, Ruifeng1; Li, Hong30; Zhang, Haiying1; Gong, Zuojiong16; Zhang, Lunli18; Zhao, Longfeng19; Dou, Xiaoguang20; Niu, Junqi21; You, Hong2; Chen, Zhi22; Ning, Qin17; Gong, Guozhong23; Wu, Shuhuan5; Ji, Wei24; Mao, Qing25; Tang, Hong26; Li, Shuchen27; Wei, Shaofeng28; Sun, Jian11; Jiang, Jiaji29; Lu, Lungen9; Jia, Jidong2; Zhuang, Hui3
关键词: China ; cirrhosis ; epidemiology ; HPV ; IL28B ; natural history
刊名: JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
发表日期: 2014-03-01
DOI: 10.1111/jgh.12398
卷: 29, 期:3, 页:545-553
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: LIVER-DISEASE ; HEPATOCELLULAR-CARCINOMA ; VIROLOGICAL RESPONSE ; RIBAVIRIN THERAPY ; HCV INFECTION ; SPONTANEOUS CLEARANCE ; PEGYLATED INTERFERON ; GENETIC-VARIATION ; PLUS RIBAVIRIN ; IL28B
英文摘要:

Background and AimChronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral and host genetic characteristics that may influence disease manifestations and clinical management.

MethodsIn this cross-sectional observational study, treatment-naive Han ethnic adults with recently confirmed chronic HCV infection were enrolled at 28 hospitals across China. HCV genotype and host interleukin 28B (IL28B) genotypes were determined and compared with patient demographic parameters and medical status.

ResultsAmong the 997 HCV-positive patients analyzed, 56.8% were infected with HCV genotype 1b, followed in prevalence by genotypes 2, 3, and 6, with substantial regional variation. Overall, 84.1% of patients were IL28B genotype CC (rs12979860), with little regional variation. Cirrhosis was reported in 10.1% of patients and was significantly associated with hepatitis B virus coinfection, low HCV viral load, low serum alanine aminotransferase, high serum aspartate aminotransferase, diabetes, and high pickled food consumption. Medical procedures were common transmission risk factors; however, lifestyle-associated risk factors, including intravenous drug abuse and tattoos or piercings, were more common in patients with HCV genotype 3 or 6.

ConclusionsMost HCV-infected Han Chinese patients were IL28B genotype CC (rs12979860). HCV genotypes varied by geographic region, and disease characteristics differed according to HCV genotype. Relatively frequent detection of advanced liver disease may reflect limitations on access to antiviral therapy, and suggests that greater awareness of factors that influence HCV-associated disease may help avoid clinical complications and improve patient outcomes.

语种: 英语
所属项目编号: 2008ZX10002-013 ; 2008ZX10002-012 ; 2012ZX10002003
项目资助者: China National Science and Technology Major Project for Infectious Diseases Control ; Bristol-Myers Squibb
WOS记录号: WOS:000331469400023
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66700
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

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作者单位: 1.West China Hosp, Chengdu, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China
4.Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Peoples R China
5.Bristol Myers Squibb Co, Wallingford, CT 06492 USA
6.Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China
8.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
9.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China
10.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
11.Shanghai Ruijin Hosp, Shanghai, Peoples R China
12.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Sch Med, Shanghai 200030, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
14.Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
15.Shandong Univ, Hosp 2, Jinan 250100, Peoples R China
16.Kunming Med Coll, Affiliated Hosp 1, Kunming, Peoples R China
17.Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China
18.Fourth Mil Med Univ, Tangdu Hosp, Xian 710032, Peoples R China
19.Hubei Wuhan Univ, Peoples Hosp, Wuhan, Peoples R China
20.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Tongji Hosp, Wuhan 430074, Peoples R China
21.Nanchang Univ, Affiliated Hosp 1, Nanchang, Peoples R China
22.Shanxi Med Univ, Affiliated Hosp 1, Taiyuan, Peoples R China
23.China Med Univ, Shengjing Hosp, Shenyang, Peoples R China
24.Jilin Univ, Hosp 1, Changchun 130023, Peoples R China
25.Ningxia Peoples Hosp, Yinchuan, Peoples R China
26.Southwest Hosp, Chongqing, Peoples R China
27.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310027, Peoples R China
28.Cent S Univ, Xiangya Hosp 2, Changsha 410083, Hunan, Peoples R China
29.Henan Prov Peoples Hosp, Zhengzhou, Peoples R China
30.Peking Univ Hlth Sci Ctr, Beijing, Peoples R China

Recommended Citation:
Rao, Huiying,Wei, Lai,Carlos Lopez-Talavera, Juan,et al. Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2014,29(3):545-553.
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