学科主题临床医学
Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection
Rao, Huiying1; Wei, Lai1; Carlos Lopez-Talavera, Juan30; Shang, Jia4; Chen, Hong6; Li, Jun7; Xie, Qing8; Gao, Zhiliang10; Wang, Lei12; Wei, Jia13; Jiang, Jianning14; Sun, Yongtao15; Yang, Ruifeng1; Li, Hong30; Zhang, Haiying1; Gong, Zuojiong16; Zhang, Lunli18; Zhao, Longfeng19; Dou, Xiaoguang20; Niu, Junqi21; You, Hong2; Chen, Zhi22; Ning, Qin17; Gong, Guozhong23; Wu, Shuhuan5; Ji, Wei24; Mao, Qing25; Tang, Hong26; Li, Shuchen27; Wei, Shaofeng28; Sun, Jian11; Jiang, Jiaji29; Lu, Lungen9; Jia, Jidong2; Zhuang, Hui3
关键词China cirrhosis epidemiology HPV IL28B natural history
刊名JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY
2014-03-01
DOI10.1111/jgh.12398
29期:3页:545-553
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]LIVER-DISEASE ; HEPATOCELLULAR-CARCINOMA ; VIROLOGICAL RESPONSE ; RIBAVIRIN THERAPY ; HCV INFECTION ; SPONTANEOUS CLEARANCE ; PEGYLATED INTERFERON ; GENETIC-VARIATION ; PLUS RIBAVIRIN ; IL28B
英文摘要

Background and AimChronic hepatitis C virus (HCV) infection is relatively frequent in China. This study investigated the clinical, demographic, and viral and host genetic characteristics that may influence disease manifestations and clinical management.

MethodsIn this cross-sectional observational study, treatment-naive Han ethnic adults with recently confirmed chronic HCV infection were enrolled at 28 hospitals across China. HCV genotype and host interleukin 28B (IL28B) genotypes were determined and compared with patient demographic parameters and medical status.

ResultsAmong the 997 HCV-positive patients analyzed, 56.8% were infected with HCV genotype 1b, followed in prevalence by genotypes 2, 3, and 6, with substantial regional variation. Overall, 84.1% of patients were IL28B genotype CC (rs12979860), with little regional variation. Cirrhosis was reported in 10.1% of patients and was significantly associated with hepatitis B virus coinfection, low HCV viral load, low serum alanine aminotransferase, high serum aspartate aminotransferase, diabetes, and high pickled food consumption. Medical procedures were common transmission risk factors; however, lifestyle-associated risk factors, including intravenous drug abuse and tattoos or piercings, were more common in patients with HCV genotype 3 or 6.

ConclusionsMost HCV-infected Han Chinese patients were IL28B genotype CC (rs12979860). HCV genotypes varied by geographic region, and disease characteristics differed according to HCV genotype. Relatively frequent detection of advanced liver disease may reflect limitations on access to antiviral therapy, and suggests that greater awareness of factors that influence HCV-associated disease may help avoid clinical complications and improve patient outcomes.

语种英语
WOS记录号WOS:000331469400023
项目编号2008ZX10002-013 ; 2008ZX10002-012 ; 2012ZX10002003
资助机构China National Science and Technology Major Project for Infectious Diseases Control ; Bristol-Myers Squibb
引用统计
被引频次:55[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66700
专题北京大学第二临床医学院_北京大学肝病研究所
北京大学第二临床医学院_心血管内科
作者单位1.West China Hosp, Chengdu, Peoples R China
2.Harbin Med Univ, Affiliated Hosp 2, Harbin, Peoples R China
3.Anhui Med Univ, Affiliated Hosp 1, Hefei, Peoples R China
4.Fujian Med Univ, Affiliated Hosp 1, Fuzhou, Peoples R China
5.Bristol Myers Squibb Co, Wallingford, CT 06492 USA
6.Peking Univ Peoples Hosp, Peking Univ Hepatol Inst, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100044, Peoples R China
7.Capital Med Univ, Beijing Friendship Hosp, Beijing, Peoples R China
8.Zhengzhou Univ, Affiliated Hosp 1, Zhengzhou 450052, Peoples R China
9.Lanzhou Univ, Hosp 1, Lanzhou 730000, Peoples R China
10.Nanjing Med Univ, Affiliated Hosp 1, Nanjing, Jiangsu, Peoples R China
11.Shanghai Ruijin Hosp, Shanghai, Peoples R China
12.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 1, Sch Med, Shanghai 200030, Peoples R China
13.Sun Yat Sen Univ, Affiliated Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
14.Southern Med Univ, Nanfang Hosp, Guangzhou, Guangdong, Peoples R China
15.Shandong Univ, Hosp 2, Jinan 250100, Peoples R China
16.Kunming Med Coll, Affiliated Hosp 1, Kunming, Peoples R China
17.Guangxi Med Univ, Affiliated Hosp 1, Nanning, Peoples R China
18.Fourth Mil Med Univ, Tangdu Hosp, Xian 710032, Peoples R China
19.Hubei Wuhan Univ, Peoples Hosp, Wuhan, Peoples R China
20.Huazhong Univ Sci & Technol, Tongji Med Coll, Affiliated Tongji Hosp, Wuhan 430074, Peoples R China
21.Nanchang Univ, Affiliated Hosp 1, Nanchang, Peoples R China
22.Shanxi Med Univ, Affiliated Hosp 1, Taiyuan, Peoples R China
23.China Med Univ, Shengjing Hosp, Shenyang, Peoples R China
24.Jilin Univ, Hosp 1, Changchun 130023, Peoples R China
25.Ningxia Peoples Hosp, Yinchuan, Peoples R China
26.Southwest Hosp, Chongqing, Peoples R China
27.Zhejiang Univ, Coll Med, Affiliated Hosp 1, Hangzhou 310027, Peoples R China
28.Cent S Univ, Xiangya Hosp 2, Changsha 410083, Hunan, Peoples R China
29.Henan Prov Peoples Hosp, Zhengzhou, Peoples R China
30.Peking Univ Hlth Sci Ctr, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Rao, Huiying,Wei, Lai,Carlos Lopez-Talavera, Juan,et al. Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection[J]. JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,2014,29(3):545-553.
APA Rao, Huiying.,Wei, Lai.,Carlos Lopez-Talavera, Juan.,Shang, Jia.,Chen, Hong.,...&Zhuang, Hui.(2014).Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection.JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY,29(3),545-553.
MLA Rao, Huiying,et al."Distribution and clinical correlates of viral and host genotypes in Chinese patients with chronic hepatitis C virus infection".JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY 29.3(2014):545-553.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Rao, Huiying]的文章
[Wei, Lai]的文章
[Carlos Lopez-Talavera, Juan]的文章
百度学术
百度学术中相似的文章
[Rao, Huiying]的文章
[Wei, Lai]的文章
[Carlos Lopez-Talavera, Juan]的文章
必应学术
必应学术中相似的文章
[Rao, Huiying]的文章
[Wei, Lai]的文章
[Carlos Lopez-Talavera, Juan]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。