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学科主题: 临床医学
题名:
The more, the less: age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies
作者: Yang Shen-miao; Chen Huan; Chen Yu-hong; Zhu Hong-hu; Zhao Ting; Liu Kai-yan
关键词: peripheral blood stem cell mobilization ; granulocyte colony-stimulating factor ; chemotherapy ; hematologic malignancies
刊名: CHINESE MEDICAL JOURNAL
发表日期: 2012-02-20
DOI: 10.3760/cma.j.issn.0366-6999.2012.04.007
卷: 125, 期:4, 页:593-598
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, General & Internal
研究领域[WOS]: General & Internal Medicine
关键词[WOS]: COLONY-STIMULATING FACTOR ; BLOOD PROGENITOR CELLS ; NON-HODGKINS-LYMPHOMA ; AUTOLOGOUS TRANSPLANTATION ; RISK-FACTORS ; RANDOMIZED EVALUATION ; MULTIPLE-MYELOMA ; GROWTH-FACTORS ; G-CSF ; COLLECTION
英文摘要:

Background Intensive treatment such as autologous peripheral blood stem cell (PBSC) transplantation is an important therapeutic strategy in many hematologic malignancies. A number of factors have been reported to impact PBSC mobilization, but the predictive factors varied from one study to another. This retrospective study assessed our current mobilization and collection protocols, and explored the factors predictive of PBSC mobilization in patients with hematologic malignancies.

Methods Data of 64 consecutive patients with hematologic malignancies (multiple myeloma, n=22; acute leukemia, n=27; lymphoma, n=15) who underwent PBSC mobilization for over 1 year were analyzed. Four patients with response to treatment of near complete remission or better were administered granulocyte colony-stimulating factor (G-CSF) to mobilize PBSCs. Sixty patients received G-CSF followed by chemotherapy mobilizing regimens. Poor mobilization (PM) was defined as when <= 2.0x10(6) CD34(+) cells/kg body weight were collected within three leukapheresis procedures.

Results The incidence of PM at the first mobilization attempt was 19% (12/64). The PM group was older than the non-PM group (median age, 51 vs. 40 years; P=0.013). In univariate analysis, there were no significant differences in gender, diagnosis, and body weight between the PM and non-PM groups. A combination of chemotherapy and G-CSF was more effective than G-CSF alone as a mobilizing regimen (P=0.019). Grade III or IV hematopoietic toxicity of chemotherapy had no significant effect on the mobilization efficacy. Supportive care and the incidence of febrile neutropenia were not significantly different between the two groups. In multivariate analysis, age (odds ratio (OR), 9.536; P=0.002) and number of previous chemotherapy courses (OR 3.132; P=0.024) were two independent negative predictive factors for CD34(+) cell yield. PM patients could be managed well by remobilization.

Conclusion Older age and a heavy load of previous chemotherapy are the negative risk factors for PBSC mobilization. Chin Med J 2012;125(4):593-598

语种: 英语
WOS记录号: WOS:000301681700007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66706
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: Peking Univ, Peoples Hosp, Inst Hematol, Beijing 100044, Peoples R China

Recommended Citation:
Yang Shen-miao,Chen Huan,Chen Yu-hong,et al. The more, the less: age and chemotherapy load are predictive of poor stem cell mobilization in patients with hematologic malignancies[J]. CHINESE MEDICAL JOURNAL,2012,125(4):593-598.
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