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学科主题: 基础医学
题名:
Ca2+ modulation in dorsal raphe plays an important role in NREM and REM sleep regulation during pentobarbital hypnosis
作者: Cui, Su-Ying; Cui, Xiang-Yu; Zhang, Juan; Wang, Zi-Jun; Yu, Bin; Sheng, Zhao-Fu; Zhang, Xue-Qiong; Shi, Xiao-Lei; Zhang, Yong-He
关键词: Calcium ; Dorsal raphe nucleus ; Pentobarbital ; Sleep
刊名: BRAIN RESEARCH
发表日期: 2011-07-27
DOI: 10.1016/j.brainres.2011.05.064
卷: 1403, 页:12-18
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: CENTRAL NERVOUS-SYSTEM ; SEROTONERGIC NEURONS ; SUPRACHIASMATIC NUCLEUS ; TRYPTOPHAN-HYDROXYLASE ; GABAERGIC NEURONS ; CHANNEL BLOCKERS ; CALCIUM ; RAT ; RECEPTORS ; TEGMENTUM
英文摘要:

Our previous studies indicated that L-type calcium channel blocker diltiazem could potentiate pentobarbital-induced hypnosis through serotonergic system. In view of the important role of dorsal raphe nucleus (DRN) on the sleep regulation and the pharmacological actions of calcium channel blocker, we presumed that Ca2+ in the DRN may play an important role in sleep regulation in pentobarbital treated rats. Therefore, we investigated whether the Ca2+ modulation in DRN by the microinjection of L-type Ca2+ channel antagonist diltiazem, agonist BAY-K-8644, Ca2+ chelator EGTA and CaCl2 would alter the sleep parameters in pentobarbital treated rats. Results showed that perfusion of the agents attenuating Ca2+ function, such as diltiazem (5 or 20 nmol) or EGTA (3 or 6 pmol) into DRN significantly increased pentobarbital (35 mg/kg, i.p.)-induced total sleep (TS), non-rapid eye movement (NREM) sleep and the slow wave sleep (SWS) ratio in NREM sleep. On the contrary, the DRN injection of the agents improving Ca2+-function, such as BAY-K-8644 (10 nmol) or CaCl2 (50 or 100 nmol) significantly reduced pentobarbital (35 mg/kg, i.p.)induced TS, NREM sleep, rapid eye movement (REM) sleep and REM sleep ratio in TS without influence on SWS. These results suggested that the suppression of Ca2+ function in DRN could increase NREM sleep including SWS, and the elevation of Ca2+ function could reduce both NREM and REM sleep in pentobarbital treated rats. (C) 2011 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 2009ZX09103-124 ; 30640070 ; 30772556 ; 20100001110048
项目资助者: National Scientific &amp ; Technological major special project ; National Natural Science Foundation of China ; Ministry of Education of China ; Peking University
WOS记录号: WOS:000293156800002
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66708
Appears in Collections:基础医学院_药理学系_期刊论文

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作者单位: Peking Univ, Dept Pharmacol, Sch Basic Med Sci, Beijing 100191, Peoples R China

Recommended Citation:
Cui, Su-Ying,Cui, Xiang-Yu,Zhang, Juan,et al. Ca2+ modulation in dorsal raphe plays an important role in NREM and REM sleep regulation during pentobarbital hypnosis[J]. BRAIN RESEARCH,2011,1403:12-18.
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