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Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis
Shi, Chuan1,2,3,4; Yu, Xin3,4; Cheung, Eric F. C.5; Shum, David H. K.6; Chan, Raymond C. K.1,2
关键词Negative symptoms Repetitive transcranial magnetic stimulation Schizophrenia Intervention Meta-analysis
刊名PSYCHIATRY RESEARCH
2014-03-30
DOI10.1016/j.psychres.2013.12.019
215期:3页:505-513
收录类别SCI ; SSCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Psychiatry
研究领域[WOS]Psychiatry
关键词[WOS]TRANSCRANIAL MAGNETIC STIMULATION ; DORSOLATERAL PREFRONTAL CORTEX ; DOUBLE-BLIND ; 1ST-EPISODE SCHIZOPHRENIA ; POSITIVE SYMPTOMS ; DEFICIT SYNDROME ; CONTROLLED-TRIAL ; PSYCHOSIS ; HYPOFRONTALITY ; INSTRUMENT
英文摘要

This study sought to determine the moderators in the treatment effect of repetitive transcranial magnetic stimulation (rTMS) on negative symptoms in schizophrenia. We performed a meta-analysis of prospective studies on the therapeutic application of rTMS in schizophrenia assessing the effects of both low-frequency and high-frequency rTMS on negative symptoms. Results indicate that rTMS is effective in alleviating negative symptoms in schizophrenia. The effect size was moderate (0.63 and 0.53, respectively). The effect size of rTMS on negative symptoms in sham-controlled trials was 0.80 as measured by the SANS and 0.41 as measured by the PANSS. A longer duration of illness was associated with poorer efficacy of rTMS on negative symptoms. A 10 Hz setting, at least 3 consecutive weeks of treatment, treatment site at the left dorsolateral prefrontal cortex (DLPFC) and a 110% motor threshold (MT) were found to be the best rTMS parameters for the treatment of negative symptoms. The results of our meta-analysis suggest that rTMS is an effective treatment option for negative symptoms in schizophrenia. The moderators of rTMS on negative symptoms included duration of illness, stimulus frequency, duration of illness, position and intensity of treatment as well as the type of outcome measures used. (C) 2013 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000333776500002
项目编号XDB02030200 ; 81088001 ; 91132701 ; O7CX031003 ; KSCX2-EW-J-8 ; 2007BAI17B04 ; Y2CX131003 ; D43TW5809
资助机构Chinese Academy of Sciences ; National Science Fund China ; Project-Oriented Hundred Talents Programme ; Knowledge Innovation Project of the Chinese Academy of Sciences ; National Key Project of Scientific and Technical Supporting Programs ; Ministry of Science &amp ; Technology of China ; CAS/SAFEA International Partnership Programme for Creative Research Teams ; Fogarty training Grant in Harvard University ; Queensland Smart Futures International Fellowship
引用统计
被引频次:46[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66716
专题北京大学精神卫生研究所
北京大学精神卫生研究所_精神科
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100871, Peoples R China
2.Castle Peak Hosp, Hong Kong, Hong Kong, Peoples R China
3.Chinese Acad Sci, Inst Psychol, Key Lab Mental Hlth, Neuropsychol & Appl Cognit Neurosci Lab, Beijing 100101, Peoples R China
4.Univ Chinese Acad Sci, Beijing, Peoples R China
5.Peking Univ, Minist Hlth, Key Lab Mental Hlth, Beijing 100871, Peoples R China
6.Griffith Univ, Griffith Hlth Inst, Behav Basis Hlth Res Program, Gold Coast, Australia
推荐引用方式
GB/T 7714
Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,et al. Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis[J]. PSYCHIATRY RESEARCH,2014,215(3):505-513.
APA Shi, Chuan,Yu, Xin,Cheung, Eric F. C.,Shum, David H. K.,&Chan, Raymond C. K..(2014).Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis.PSYCHIATRY RESEARCH,215(3),505-513.
MLA Shi, Chuan,et al."Revisiting the therapeutic effect of rTMS on negative symptoms in schizophrenia: A meta-analysis".PSYCHIATRY RESEARCH 215.3(2014):505-513.
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