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Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases
Cui, Yong1; Zhang, Xiao-Peng1; Sun, Ying-Shi1; Tang, Lei1; Shen, Lin2
刊名RADIOLOGY
2008-09-01
DOI10.1148/radiol.2483071407
248期:3页:894-900
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]EARLY SURROGATE MARKER ; IN-VIVO ; TUMOR NECROSIS ; HEPATOCELLULAR-CARCINOMA ; THERAPEUTIC-EFFICACY ; COLORECTAL-CANCER ; LIVER METASTASES ; GASTRIC-CANCER ; BREAST-CANCER ; RABBIT MODEL
英文摘要

Purpose: To evaluate the ability of the apparent diffusion coefficient (ADC) to help predict response to chemotherapy in patients with colorectal and gastric hepatic metastases.

Materials and Methods: Institutional review board approval was obtained; all patients provided informed consent. Standard magnetic resonance (MR) imaging and diffusion-weighted (DW) MR imaging were performed before and 3, 7, and 42 days after initiating chemotherapy for 87 hepatic metastases in 23 colorectal and gastric cancer patients (16 men, seven women; mean age, 55.7 years; range, 33-71 years). Lesions were classified as either responding or nonresponding, according to changes in size at the end of therapy. Linear mixed-effects modeling was applied to analyze change in ADCs and size following treatment. The Pearson correlation test was calculated between those ADC parameters and tumor response.

Results: Thirty-eight responding and 49 nonresponding metastatic lesions were evaluated. Pretherapy mean ADCs in responding lesions were significantly lower than those of nonresponding lesions (P = .003). An early increase in ADCs (on day 3 or 7) was observed in responding lesions but not in nonresponding lesions (P = .002). Weak but significant correlations were found between final tumor size reduction and both pretreatment ADCs (P < .006) and early ADC changes (day 3, P = .004; day 7, P < .001).

Conclusion: ADC seems to be a promising tool for helping predict and monitor the early response to chemotherapy of hepatic metastases from colorectal and gastric carcinomas. (C) RSNA, 2008.

语种英语
WOS记录号WOS:000258541500026
项目编号2006CB705706
资助机构National Basic Research Program of China
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被引频次:237[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66719
专题北京大学临床肿瘤学院_医学影像科
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Radiol, Beijing 100036, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Digest Dis, Beijing 100036, Peoples R China
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Cui, Yong,Zhang, Xiao-Peng,Sun, Ying-Shi,et al. Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases[J]. RADIOLOGY,2008,248(3):894-900.
APA Cui, Yong,Zhang, Xiao-Peng,Sun, Ying-Shi,Tang, Lei,&Shen, Lin.(2008).Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases.RADIOLOGY,248(3),894-900.
MLA Cui, Yong,et al."Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases".RADIOLOGY 248.3(2008):894-900.
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