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学科主题: 临床医学
题名:
Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases
作者: Cui, Yong1; Zhang, Xiao-Peng1; Sun, Ying-Shi1; Tang, Lei1; Shen, Lin2
刊名: RADIOLOGY
发表日期: 2008-09-01
DOI: 10.1148/radiol.2483071407
卷: 248, 期:3, 页:894-900
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: EARLY SURROGATE MARKER ; IN-VIVO ; TUMOR NECROSIS ; HEPATOCELLULAR-CARCINOMA ; THERAPEUTIC-EFFICACY ; COLORECTAL-CANCER ; LIVER METASTASES ; GASTRIC-CANCER ; BREAST-CANCER ; RABBIT MODEL
英文摘要:

Purpose: To evaluate the ability of the apparent diffusion coefficient (ADC) to help predict response to chemotherapy in patients with colorectal and gastric hepatic metastases.

Materials and Methods: Institutional review board approval was obtained; all patients provided informed consent. Standard magnetic resonance (MR) imaging and diffusion-weighted (DW) MR imaging were performed before and 3, 7, and 42 days after initiating chemotherapy for 87 hepatic metastases in 23 colorectal and gastric cancer patients (16 men, seven women; mean age, 55.7 years; range, 33-71 years). Lesions were classified as either responding or nonresponding, according to changes in size at the end of therapy. Linear mixed-effects modeling was applied to analyze change in ADCs and size following treatment. The Pearson correlation test was calculated between those ADC parameters and tumor response.

Results: Thirty-eight responding and 49 nonresponding metastatic lesions were evaluated. Pretherapy mean ADCs in responding lesions were significantly lower than those of nonresponding lesions (P = .003). An early increase in ADCs (on day 3 or 7) was observed in responding lesions but not in nonresponding lesions (P = .002). Weak but significant correlations were found between final tumor size reduction and both pretreatment ADCs (P < .006) and early ADC changes (day 3, P = .004; day 7, P < .001).

Conclusion: ADC seems to be a promising tool for helping predict and monitor the early response to chemotherapy of hepatic metastases from colorectal and gastric carcinomas. (C) RSNA, 2008.

语种: 英语
所属项目编号: 2006CB705706
项目资助者: National Basic Research Program of China
WOS记录号: WOS:000258541500026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66719
Appears in Collections:北京大学临床肿瘤学院_医学影像科_期刊论文

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作者单位: 1.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Radiol, Beijing 100036, Peoples R China
2.Peking Univ, Beijing Canc Hosp & Inst, Sch Oncol, Dept Digest Dis, Beijing 100036, Peoples R China

Recommended Citation:
Cui, Yong,Zhang, Xiao-Peng,Sun, Ying-Shi,et al. Apparent diffusion coefficient: Potential imaging biomarker for prediction and early detection of response to chemotherapy in hepatic metastases[J]. RADIOLOGY,2008,248(3):894-900.
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