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学科主题基础医学
Identification and analysis of tumour-associated antigens in hepatocellular carcinoma
Shi, YY; Wang, HC; Yin, YH; Sun, WS; Li, Y; Zhang, CQ; Wang, Y; Wang, S; Chen, WF
关键词hepatocellular carcinoma serological analysis of recombinant cDNA expression libraries tumour antigens cDNA microarray
刊名BRITISH JOURNAL OF CANCER
2005-03-14
DOI10.1038/sj.bjc.6602460
92期:5页:929-934
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]HUMAN COLON-CANCER ; T-CELL RESPONSES ; GENE-EXPRESSION ; ISCOMATRIX ADJUVANT ; INDUCTION ; PROTEIN ; IMMUNOTHERAPY ; OVEREXPRESSION ; MIGRATION ; MELANOMA
英文摘要

To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libraries (SEREX). The mRNA expression patterns of 14 of these 30 antigens were altered in cancer as further revealed by cDNA microarray, with upregulation for nine and downregulation for five antigens. One of the upregulated antigens was cancer-testis (CT) antigen (CAGE), which had been previously reported to be expressed exclusively in normal gametogenic tissues and aberrantly expressed in a variety of cancer cells. In our study, CAGE mRNA was expressed in 39.4% of HCC patients, 73.3% of patients with gastric cancer and 30.8% of patients with colorectal cancer. Antibodies against CAGE protein were detected in approximately 5.1% of the sera from HCC patients, 8.3% of that from gastric cancer patients and 7.3% of that from colorectal cancer patients. The relative high incidence of CAGE in cancer cells makes it a potential target for vaccine design. Another antigen of great interest is transgelin 2. The overexpression of transgelin 2 mRNA in a large per cent (69%) of HCC points to its potential as a diagnostic marker for HCC.

语种英语
WOS记录号WOS:000227827300023
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被引频次:56[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
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条目标识符http://ir.bjmu.edu.cn/handle/400002259/66721
专题北京大学基础医学院_免疫学系
作者单位1.Sun Yat Sen Univ, Ctr Canc, Guangzhou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Surg 2, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Lab Surg Oncol, Beijing 100871, Peoples R China
5.Beijing Canc Hosp, Canc Biol Therapy & Diag Ctr, Beijing, Peoples R China
6.Shandong Univ, Sch Med, Dept Immunol, Jinan 250100, Peoples R China
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Shi, YY,Wang, HC,Yin, YH,et al. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma[J]. BRITISH JOURNAL OF CANCER,2005,92(5):929-934.
APA Shi, YY.,Wang, HC.,Yin, YH.,Sun, WS.,Li, Y.,...&Chen, WF.(2005).Identification and analysis of tumour-associated antigens in hepatocellular carcinoma.BRITISH JOURNAL OF CANCER,92(5),929-934.
MLA Shi, YY,et al."Identification and analysis of tumour-associated antigens in hepatocellular carcinoma".BRITISH JOURNAL OF CANCER 92.5(2005):929-934.
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