北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 基础医学院  > 免疫学系  > 期刊论文
学科主题: 基础医学
题名:
Identification and analysis of tumour-associated antigens in hepatocellular carcinoma
作者: Shi, YY; Wang, HC; Yin, YH; Sun, WS; Li, Y; Zhang, CQ; Wang, Y; Wang, S; Chen, WF
关键词: hepatocellular carcinoma ; serological analysis of recombinant cDNA expression libraries ; tumour antigens ; cDNA microarray
刊名: BRITISH JOURNAL OF CANCER
发表日期: 2005-03-14
DOI: 10.1038/sj.bjc.6602460
卷: 92, 期:5, 页:929-934
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: HUMAN COLON-CANCER ; T-CELL RESPONSES ; GENE-EXPRESSION ; ISCOMATRIX ADJUVANT ; INDUCTION ; PROTEIN ; IMMUNOTHERAPY ; OVEREXPRESSION ; MIGRATION ; MELANOMA
英文摘要:

To identify tumour and tumour-associated antigens in patients with hepatocellular carcinoma (HCC) one may find potential diagnostic markers and immunotherapeutic targets. In the current study, 30 distinct antigens reactive with serum IgG from HCC patients were identified by serological analysis of cDNA expression libraries (SEREX). The mRNA expression patterns of 14 of these 30 antigens were altered in cancer as further revealed by cDNA microarray, with upregulation for nine and downregulation for five antigens. One of the upregulated antigens was cancer-testis (CT) antigen (CAGE), which had been previously reported to be expressed exclusively in normal gametogenic tissues and aberrantly expressed in a variety of cancer cells. In our study, CAGE mRNA was expressed in 39.4% of HCC patients, 73.3% of patients with gastric cancer and 30.8% of patients with colorectal cancer. Antibodies against CAGE protein were detected in approximately 5.1% of the sera from HCC patients, 8.3% of that from gastric cancer patients and 7.3% of that from colorectal cancer patients. The relative high incidence of CAGE in cancer cells makes it a potential target for vaccine design. Another antigen of great interest is transgelin 2. The overexpression of transgelin 2 mRNA in a large per cent (69%) of HCC points to its potential as a diagnostic marker for HCC.

语种: 英语
WOS记录号: WOS:000227827300023
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66721
Appears in Collections:基础医学院_免疫学系_期刊论文

Files in This Item:
File Name/ File Size Content Type Version Access License
6602460a.pdf(125KB)期刊论文出版稿限制开放 联系获取全文

作者单位: 1.Sun Yat Sen Univ, Ctr Canc, Guangzhou, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100083, Peoples R China
3.Peking Univ, Peoples Hosp, Dept Surg 2, Beijing 100871, Peoples R China
4.Peking Univ, Peoples Hosp, Lab Surg Oncol, Beijing 100871, Peoples R China
5.Beijing Canc Hosp, Canc Biol Therapy & Diag Ctr, Beijing, Peoples R China
6.Shandong Univ, Sch Med, Dept Immunol, Jinan 250100, Peoples R China

Recommended Citation:
Shi, YY,Wang, HC,Yin, YH,et al. Identification and analysis of tumour-associated antigens in hepatocellular carcinoma[J]. BRITISH JOURNAL OF CANCER,2005,92(5):929-934.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Shi, YY]'s Articles
[Wang, HC]'s Articles
[Yin, YH]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Shi, YY]‘s Articles
[Wang, HC]‘s Articles
[Yin, YH]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace