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学科主题: 基础医学
题名:
The immunosuppressive tumor microenvironment in hepatocellular carcinoma
作者: Pang, Yan-Li1; Zhang, Hua-Gang1; Peng, Ji-Run2; Pang, Xue-Wen1; Yu, Shu1; Xing, Qiao1; Yu, Xin2; Gong, Lei2; Yin, Yan-Hui1; Zhang, Yu1; Chen, Wei-Feng1
关键词: Tumor infiltrating lymphocytes ; Immunosuppressive factors ; Foxp3(+) cells ; Tumor microenvironment ; Hepatocellular carcinoma
刊名: CANCER IMMUNOLOGY IMMUNOTHERAPY
发表日期: 2009-06-01
DOI: 10.1007/s00262-008-0603-5
卷: 58, 期:6, 页:877-886
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology ; Immunology
研究领域[WOS]: Oncology ; Immunology
关键词[WOS]: REGULATORY T-CELLS ; TRANSCRIPTION FACTOR FOXP3 ; CANCER-PATIENTS ; TGF-BETA ; TRANSFORMING GROWTH-FACTOR-BETA-1 ; ANTITUMOR IMMUNITY ; OVARIAN-CANCER ; IN-VIVO ; IMMUNOTHERAPY ; RESPONSES
英文摘要:

Increasing evidence indicates the immunosuppressive nature of the local environment in tumor. The present study was focused on analyzing the immune status within hepatocellular carcinoma. In contrast to the increasing number of CD4(+) T cells, CD8(+), CD3(-)CD56(+), CD3(+)CD56(+), and gamma delta T cells were all found to be under-represented in tumor infiltrating lymphocytes. Notably, the relative abundance of CD3(+)CD56(+) cells appeared to be correlated with patient survival. Functional analysis demonstrated that CD4(+) cells in the tumor tended to produce more IL-10 but less IFN-gamma, whereas CD8(+) cells showed impaired capacity for the production of both IFN-gamma and perforin. Consistent with previous reports, we observed a significant increase of Foxp3(+) cells in the tumor tissue. Intriguingly, although over 90% of CD4(+)CD25(high) cells were found to be Foxp3(+), the majority of Foxp3(+) cells were identified in the CD4(+)CD25(medium) and CD4(+)CD25(-) subsets. In support of its role as a negative regulator, CD4(+)CD25(high) cells suppressed the proliferation of CD4(+)CD25(-) cells isolated from the same tissues in an APC dependent manner. In conclusion, the tumor microenvironment of hepatocellular carcinoma is featured by the presence of multiple immunosuppressive factors.

语种: 英语
所属项目编号: 7071006 ; 7061003 ; 2006AA02Z486
项目资助者: Beijing Municipal Government Foundation for Natural Sciences ; National 863 High Technology Program of China
WOS记录号: WOS:000264832700005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66723
Appears in Collections:基础医学院_免疫学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China

Recommended Citation:
Pang, Yan-Li,Zhang, Hua-Gang,Peng, Ji-Run,et al. The immunosuppressive tumor microenvironment in hepatocellular carcinoma[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2009,58(6):877-886.
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