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学科主题基础医学
The immunosuppressive tumor microenvironment in hepatocellular carcinoma
Pang, Yan-Li1; Zhang, Hua-Gang1; Peng, Ji-Run2; Pang, Xue-Wen1; Yu, Shu1; Xing, Qiao1; Yu, Xin2; Gong, Lei2; Yin, Yan-Hui1; Zhang, Yu1; Chen, Wei-Feng1
关键词Tumor infiltrating lymphocytes Immunosuppressive factors Foxp3(+) cells Tumor microenvironment Hepatocellular carcinoma
刊名CANCER IMMUNOLOGY IMMUNOTHERAPY
2009-06-01
DOI10.1007/s00262-008-0603-5
58期:6页:877-886
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology ; Immunology
资助者Beijing Municipal Government Foundation for Natural Sciences ; National 863 High Technology Program of China ; Beijing Municipal Government Foundation for Natural Sciences ; National 863 High Technology Program of China
研究领域[WOS]Oncology ; Immunology
关键词[WOS]REGULATORY T-CELLS ; TRANSCRIPTION FACTOR FOXP3 ; CANCER-PATIENTS ; TGF-BETA ; TRANSFORMING GROWTH-FACTOR-BETA-1 ; ANTITUMOR IMMUNITY ; OVARIAN-CANCER ; IN-VIVO ; IMMUNOTHERAPY ; RESPONSES
英文摘要

Increasing evidence indicates the immunosuppressive nature of the local environment in tumor. The present study was focused on analyzing the immune status within hepatocellular carcinoma. In contrast to the increasing number of CD4(+) T cells, CD8(+), CD3(-)CD56(+), CD3(+)CD56(+), and gamma delta T cells were all found to be under-represented in tumor infiltrating lymphocytes. Notably, the relative abundance of CD3(+)CD56(+) cells appeared to be correlated with patient survival. Functional analysis demonstrated that CD4(+) cells in the tumor tended to produce more IL-10 but less IFN-gamma, whereas CD8(+) cells showed impaired capacity for the production of both IFN-gamma and perforin. Consistent with previous reports, we observed a significant increase of Foxp3(+) cells in the tumor tissue. Intriguingly, although over 90% of CD4(+)CD25(high) cells were found to be Foxp3(+), the majority of Foxp3(+) cells were identified in the CD4(+)CD25(medium) and CD4(+)CD25(-) subsets. In support of its role as a negative regulator, CD4(+)CD25(high) cells suppressed the proliferation of CD4(+)CD25(-) cells isolated from the same tissues in an APC dependent manner. In conclusion, the tumor microenvironment of hepatocellular carcinoma is featured by the presence of multiple immunosuppressive factors.

语种英语
所属项目编号7071006 ; 7061003 ; 2006AA02Z486
资助者Beijing Municipal Government Foundation for Natural Sciences ; National 863 High Technology Program of China ; Beijing Municipal Government Foundation for Natural Sciences ; National 863 High Technology Program of China
WOS记录号WOS:000264832700005
引用统计
被引频次:27[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66723
专题基础医学院_免疫学系
作者单位1.Peking Univ, Hlth Sci Ctr, Dept Immunol, Beijing 100191, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Peoples Hosp, Ctr Hepatobiliary Surg, Beijing 100044, Peoples R China
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GB/T 7714
Pang, Yan-Li,Zhang, Hua-Gang,Peng, Ji-Run,et al. The immunosuppressive tumor microenvironment in hepatocellular carcinoma[J]. CANCER IMMUNOLOGY IMMUNOTHERAPY,2009,58(6):877-886.
APA Pang, Yan-Li.,Zhang, Hua-Gang.,Peng, Ji-Run.,Pang, Xue-Wen.,Yu, Shu.,...&Chen, Wei-Feng.(2009).The immunosuppressive tumor microenvironment in hepatocellular carcinoma.CANCER IMMUNOLOGY IMMUNOTHERAPY,58(6),877-886.
MLA Pang, Yan-Li,et al."The immunosuppressive tumor microenvironment in hepatocellular carcinoma".CANCER IMMUNOLOGY IMMUNOTHERAPY 58.6(2009):877-886.
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