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学科主题临床医学
Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China
Ji, Linong1; Weng, Jianping2; Lu, Juming3; Guo, Xiaohui4; Yang, Wenying5; Jia, Weiping6; Zou, Dajin7; Zhou, Zhiguang8; Zhu, Dalong9; Ji, Qiuhe10; Shi, Lixin11; Yang, Xilin12
关键词Hyperglycemia LDL cholesterol Triglyceride Type 2 diabetes Chinese
刊名JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION
2014-09-01
DOI10.1007/s40618-014-0115-4
37期:9页:843-852
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
资助者Novo Nordisk, China ; Novo Nordisk, China
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]BLOOD-GLUCOSE CONTROL ; FOLLOW-UP ; PREVALENCE ; ALBUMINURIA ; REGISTRY ; COMPLICATIONS ; DYSLIPIDEMIA ; PREVENTION ; ADVANCE ; DISEASE
英文摘要

Purpose Type 2 diabetes (T2D) increases the risk of cardiovascular disease (CVD). Achieving glycated hemoglobin (HbA1c) below 7.0 % in newly diagnosed T2D reduced CVD risk. It is uncertain whether HbA1c below 7.0 % in T2D with varying duration of diabetes also reduced CVD risk. This study investigated the associations between hyperglycemia and abnormal lipid metabolism in patients with T2D.

Methods We conducted a survey of 19,757 outpatients with T2D who were 18 years of age or more and treated with oral antidiabetes drugs (OADs) alone or OADs combined with other drugs. The coverage rates of the 3A hospitals were 74.4 % for Beijing (n = 32), 76 % for Shanghai (n = 22), 55 % for Tianjin (n = 11) and 29.3 % for Guangzhou (n = 12). Abnormal lipids were defined as >= 2.6 mmol/L for low-density lipoprotein (LDL) cholesterol, <= 1.0 mmol/L in men and <= 1.3 mmol/L in women for high-density lipoprotein (HDL) cholesterol; >= 1.7 mmol/L for triglyceride. Logistic regression stratified on city and hospital was used to obtain odds ratio (OR) of hyperglycemia for abnormal lipids.

Results The patients had 4.0 (interquartile range 1.7-8.8) years of duration of diabetes. HbA1c >= 7.0 % was associated with increased risk of high LDL cholesterol (multivariable OR of >= 7.0 vs. <6.0 %:1.37, 95 % confidence interval 1.19-1.57). HbA1c >= 6.5 % was associated increased risk of high triglyceride. HbA1c was associated with low HDL cholesterol in a J-shaped manner, whereby HbA1c levels of <6.0 % as well as >= 6.5 % being associated with increased risk of low HDL cholesterol.

Conclusions Hyperglycemia defined as HbA1c >= 7.0 % increased risk of high LDL cholesterol in T2D.

语种英语
资助者Novo Nordisk, China ; Novo Nordisk, China
WOS记录号WOS:000342063500009
Citation statistics
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66726
Collection北京大学第二临床医学院_内分泌科
作者单位1.Sinojapan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China
2.Changhai Hosp Shanghai, Dept Endocrinol, Shanghai, Peoples R China
3.Hosp Guiyang Med Univ, Dept Endocrinol, Guiyang, Guizhou, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
7.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
8.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Endocrinol, Shanghai 200030, Peoples R China
9.Cent S Univ, Xiangya Hosp 2, Dept Endocrinol, Changsha, Hunan, Peoples R China
10.Nanjing Drum Tower Hosp, Dept Endocrinol, Nanjing, Jiangsu, Peoples R China
11.4th Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China
12.Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Tianjin 300070, Peoples R China
Recommended Citation
GB/T 7714
Ji, Linong,Weng, Jianping,Lu, Juming,et al. Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China[J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION,2014,37(9):843-852.
APA Ji, Linong.,Weng, Jianping.,Lu, Juming.,Guo, Xiaohui.,Yang, Wenying.,...&Yang, Xilin.(2014).Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China.JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION,37(9),843-852.
MLA Ji, Linong,et al."Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China".JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 37.9(2014):843-852.
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