|Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China|
|Ji, Linong1; Weng, Jianping2; Lu, Juming3; Guo, Xiaohui4; Yang, Wenying5; Jia, Weiping6; Zou, Dajin7; Zhou, Zhiguang8; Zhu, Dalong9; Ji, Qiuhe10; Shi, Lixin11; Yang, Xilin12|
|关键词||Hyperglycemia LDL cholesterol Triglyceride Type 2 diabetes Chinese|
|刊名||JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION|
|WOS标题词||Science & Technology|
|类目[WOS]||Endocrinology & Metabolism|
|研究领域[WOS]||Endocrinology & Metabolism|
|关键词[WOS]||BLOOD-GLUCOSE CONTROL ; FOLLOW-UP ; PREVALENCE ; ALBUMINURIA ; REGISTRY ; COMPLICATIONS ; DYSLIPIDEMIA ; PREVENTION ; ADVANCE ; DISEASE|
Purpose Type 2 diabetes (T2D) increases the risk of cardiovascular disease (CVD). Achieving glycated hemoglobin (HbA1c) below 7.0 % in newly diagnosed T2D reduced CVD risk. It is uncertain whether HbA1c below 7.0 % in T2D with varying duration of diabetes also reduced CVD risk. This study investigated the associations between hyperglycemia and abnormal lipid metabolism in patients with T2D.
Methods We conducted a survey of 19,757 outpatients with T2D who were 18 years of age or more and treated with oral antidiabetes drugs (OADs) alone or OADs combined with other drugs. The coverage rates of the 3A hospitals were 74.4 % for Beijing (n = 32), 76 % for Shanghai (n = 22), 55 % for Tianjin (n = 11) and 29.3 % for Guangzhou (n = 12). Abnormal lipids were defined as >= 2.6 mmol/L for low-density lipoprotein (LDL) cholesterol, <= 1.0 mmol/L in men and <= 1.3 mmol/L in women for high-density lipoprotein (HDL) cholesterol; >= 1.7 mmol/L for triglyceride. Logistic regression stratified on city and hospital was used to obtain odds ratio (OR) of hyperglycemia for abnormal lipids.
Results The patients had 4.0 (interquartile range 1.7-8.8) years of duration of diabetes. HbA1c >= 7.0 % was associated with increased risk of high LDL cholesterol (multivariable OR of >= 7.0 vs. <6.0 %:1.37, 95 % confidence interval 1.19-1.57). HbA1c >= 6.5 % was associated increased risk of high triglyceride. HbA1c was associated with low HDL cholesterol in a J-shaped manner, whereby HbA1c levels of <6.0 % as well as >= 6.5 % being associated with increased risk of low HDL cholesterol.
Conclusions Hyperglycemia defined as HbA1c >= 7.0 % increased risk of high LDL cholesterol in T2D.
|资助机构||Novo Nordisk, China|
|作者单位||1.Sinojapan Friendship Hosp, Dept Endocrinol, Beijing, Peoples R China|
2.Changhai Hosp Shanghai, Dept Endocrinol, Shanghai, Peoples R China
3.Hosp Guiyang Med Univ, Dept Endocrinol, Guiyang, Guizhou, Peoples R China
4.Peking Univ, Peoples Hosp, Dept Endocrinol, Beijing 100871, Peoples R China
5.Sun Yat Sen Univ, Affiliated Hosp 3, Dept Endocrinol, Guangzhou 510275, Guangdong, Peoples R China
6.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol, Beijing, Peoples R China
7.Peking Univ, Hosp 1, Dept Endocrinol, Beijing 100871, Peoples R China
8.Shanghai Jiao Tong Univ, Shanghai Peoples Hosp 6, Dept Endocrinol, Shanghai 200030, Peoples R China
9.Cent S Univ, Xiangya Hosp 2, Dept Endocrinol, Changsha, Hunan, Peoples R China
10.Nanjing Drum Tower Hosp, Dept Endocrinol, Nanjing, Jiangsu, Peoples R China
11.4th Mil Med Univ, Xijing Hosp, Dept Endocrinol, Xian, Shaanxi, Peoples R China
12.Tianjin Med Univ, Sch Publ Hlth, Dept Epidemiol & Biostat, Tianjin 300070, Peoples R China
|Ji, Linong,Weng, Jianping,Lu, Juming,et al. Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China[J]. JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION,2014,37(9):843-852.|
|APA||Ji, Linong.,Weng, Jianping.,Lu, Juming.,Guo, Xiaohui.,Yang, Wenying.,...&Yang, Xilin.(2014).Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China.JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION,37(9),843-852.|
|MLA||Ji, Linong,et al."Hyperglycemia and duration of diabetes as risk factors for abnormal lipids: a cross sectional survey of 19,757 patients with type 2 diabetes in China".JOURNAL OF ENDOCRINOLOGICAL INVESTIGATION 37.9(2014):843-852.|