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学科主题: 药物依赖
题名:
Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats
作者: Li, Su-xia1; Zou, Yan2; Liu, Li-jing1; Wu, Ping1; Lu, Lin1
关键词: Aripiprazole ; Morphine ; Dopamine ; Serotonin ; Reinstatement ; Conditioned preference place
刊名: PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
发表日期: 2009-04-01
DOI: 10.1016/j.pbb.2009.01.014
卷: 92, 期:2, 页:370-375
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]: Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]: ATYPICAL ANTIPSYCHOTIC-DRUG ; NUCLEUS-ACCUMBENS DOPAMINE ; COCAINE-SEEKING ; D-AMPHETAMINE ; 5,7-DIHYDROXYTRYPTAMINE LESIONS ; RECEPTOR ACTIVATION ; INCREASES DOPAMINE ; ALCOHOL DEPENDENCE ; PREFRONTAL CORTEX ; SEROTONIN RELEASE
英文摘要:

Aripiprazole is an atypical antipsychotic drug primarily characterized by partial agonist activity at dopamine (DA) D(2) receptors and serotonin-1A (5-hydroxytryptamine, 5-HT(1A)) receptors and minimal side effects. Based on its pharmacological profile, including stabilization of mesocorticolimbic DA activity (a pathway implicated in drug addiction), we investigated the effects of aripiprazole on relapse to morphine seeking in rats. In experiment 1, rats underwent morphine-induced conditioned place preference (CPP) training with alternate injections of morphine (5 mg/kg, s.c.) and saline (1 ml/kg, s.c.) for 8 consecutive days. To examine the effect of aripiprazole on the expression of morphine-induced CPP, rats received aripiprazole (0, 0.03, 0.1, and 0.3 mg/kg. i.p.) 30 min before testing for the expression of CPP. In experiment 2, rats underwent the same CPP training as in experiment 1 and subsequent extinction training. To examine the effect of aripiprazole on reinstatement of morphine-induced CPP, rats received aripiprazole 30 min before testing for reinstatement of CPP. In experiment 3. to assess the effects of aripiprazole on locomotor activity. aripiprazole was administered 30 min before testing for locomotor activity. Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity. The D(2) and 5-HT(1A) partial agonist and 5-HT(2A) antagonist properties of aripiprazole likely account for the blockade of relapse to drug seeking. These findings suggest that aripiprazole may have therapeutic value for reducing craving and preventing relapse to drug seeking. (C) 2009 Published by Elsevier Inc.

语种: 英语
所属项目编号: 2007CB512302 ; 2009CB522004 ; 2006AA02Z4D1 ; 30670713 ; 30725016
项目资助者: National Basic Research Program of China ; National High Technology Research and Development Program of China ; Natural Science Foundation of China
WOS记录号: WOS:000264255300026
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66732
Appears in Collections:中国药物依赖性研究所_期刊论文

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作者单位: 1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China

Recommended Citation:
Li, Su-xia,Zou, Yan,Liu, Li-jing,et al. Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(2):370-375.
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