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Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats
Li, Su-xia1; Zou, Yan2; Liu, Li-jing1; Wu, Ping1; Lu, Lin1
关键词Aripiprazole Morphine Dopamine Serotonin Reinstatement Conditioned preference place
刊名PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR
2009-04-01
DOI10.1016/j.pbb.2009.01.014
92期:2页:370-375
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Behavioral Sciences ; Neurosciences ; Pharmacology & Pharmacy
研究领域[WOS]Behavioral Sciences ; Neurosciences & Neurology ; Pharmacology & Pharmacy
关键词[WOS]ATYPICAL ANTIPSYCHOTIC-DRUG ; NUCLEUS-ACCUMBENS DOPAMINE ; COCAINE-SEEKING ; D-AMPHETAMINE ; 5,7-DIHYDROXYTRYPTAMINE LESIONS ; RECEPTOR ACTIVATION ; INCREASES DOPAMINE ; ALCOHOL DEPENDENCE ; PREFRONTAL CORTEX ; SEROTONIN RELEASE
英文摘要

Aripiprazole is an atypical antipsychotic drug primarily characterized by partial agonist activity at dopamine (DA) D(2) receptors and serotonin-1A (5-hydroxytryptamine, 5-HT(1A)) receptors and minimal side effects. Based on its pharmacological profile, including stabilization of mesocorticolimbic DA activity (a pathway implicated in drug addiction), we investigated the effects of aripiprazole on relapse to morphine seeking in rats. In experiment 1, rats underwent morphine-induced conditioned place preference (CPP) training with alternate injections of morphine (5 mg/kg, s.c.) and saline (1 ml/kg, s.c.) for 8 consecutive days. To examine the effect of aripiprazole on the expression of morphine-induced CPP, rats received aripiprazole (0, 0.03, 0.1, and 0.3 mg/kg. i.p.) 30 min before testing for the expression of CPP. In experiment 2, rats underwent the same CPP training as in experiment 1 and subsequent extinction training. To examine the effect of aripiprazole on reinstatement of morphine-induced CPP, rats received aripiprazole 30 min before testing for reinstatement of CPP. In experiment 3. to assess the effects of aripiprazole on locomotor activity. aripiprazole was administered 30 min before testing for locomotor activity. Aripiprazole significantly decreased the reinstatement of CPP induced by a priming injection of morphine but had no effect on the expression of morphine-induced CPP or locomotor activity. The D(2) and 5-HT(1A) partial agonist and 5-HT(2A) antagonist properties of aripiprazole likely account for the blockade of relapse to drug seeking. These findings suggest that aripiprazole may have therapeutic value for reducing craving and preventing relapse to drug seeking. (C) 2009 Published by Elsevier Inc.

语种英语
WOS记录号WOS:000264255300026
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66732
专题北京大学医学部管理机构_医学部
中国药物依赖性研究所
作者单位1.Peking Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
2.Natl Res Inst Family Planning, Beijing 100081, Peoples R China
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GB/T 7714
Li, Su-xia,Zou, Yan,Liu, Li-jing,et al. Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats[J]. PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,2009,92(2):370-375.
APA Li, Su-xia,Zou, Yan,Liu, Li-jing,Wu, Ping,&Lu, Lin.(2009).Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats.PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR,92(2),370-375.
MLA Li, Su-xia,et al."Aripiprazole blocks reinstatement but not expression of morphine conditioned place preference in rats".PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR 92.2(2009):370-375.
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