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学科主题: 临床医学
题名:
Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment
作者: Zhao, Jun1; Du, Chang-Zheng1; Sun, Ying-Shi2; Gu, Jin1
关键词: Rectal cancer ; Local recurrence ; Prognosis ; Survival ; Surgery
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2012-12-21
DOI: 10.3748/wjg.v18.i47.7015
卷: 18, 期:47, 页:7015-7020
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: TOTAL MESORECTAL EXCISION ; COLORECTAL-CANCER ; CURATIVE RESECTION ; PELVIC RECURRENCE ; SURGERY ; MANAGEMENT ; CARCINOMA ; OUTCOMES ; THERAPY ; SALVAGE
英文摘要:

AIM: To investigate the patterns and decisive prognostic factors for local recurrence of rectal cancer treated with a multidisciplinary team (MDT) modality.

METHODS: Ninety patients with local recurrence were studied, out of 1079 consecutive rectal cancer patients who underwent curative surgery from 1999 to 2007. For each patient, the recurrence pattern was assessed by specialist radiologists from the MDT using imaging, and the treatment strategy was decided after discussion by the MDT. The associations between clinicopathological factors and long-term outcomes were evaluated using both univariate and multivariate analysis.

RESULTS: The recurrence pattern was classified as follows: Twenty-seven (30%) recurrent tumors were evaluated as axial type, 21 (23.3%) were anterior type, 8 (8.9%) were posterior type, and 13 (25.6%) were lateral type. Forty-one patients had tumors that were evaluated as resectable by the MDT and ultimately received surgery, and R0 resection was achieved in 36 (87.8%) of these patients. The recurrence pattern was closely associated with resectability and R0 resection rate (P < 0.001). The recurrence pattern, interval to recurrence, and R0 resection were significantly associated with 5-year survival rate in univariate analysis. Multivariate analysis showed that the R0 resection was the unique independent factor affecting long-term survival.

CONCLUSION: The MDT modality improves patient selection for surgery by enabling accurate classification of the recurrence pattern; R0 resection is the most significant factor affecting long-term survival. (C) 2012 Baishideng. All rights reserved.

语种: 英语
WOS记录号: WOS:000313114100021
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66733
Appears in Collections:北京大学临床肿瘤学院_医学影像科_期刊论文

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作者单位: 1.Peking Univ, Key Lab Carcinogenesis & Translat Res, Beijing Canc Hosp & Inst, Dept Colorectal Surg,Minist Educ,Canc Hosp, Beijing 100142, Peoples R China
2.Peking Univ, Canc Hosp, Dept Radiol, Beijing 100142, Peoples R China

Recommended Citation:
Zhao, Jun,Du, Chang-Zheng,Sun, Ying-Shi,et al. Patterns and prognosis of locally recurrent rectal cancer following multidisciplinary treatment[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2012,18(47):7015-7020.
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