IR@PKUHSC  > 北京大学第二临床医学院  > 放射科
学科主题临床医学
Diffusion-Weighted MR Imaging in Pancreatic Endocrine Tumors Correlated With Histopathologic Characteristics
Wang, Yi1,2; Chen, Zongming E.3; Yaghmai, Vahid1; Nikolaidis, Paul1; McCarthy, Robert J.4; Merrick, Laura1; Miller, Frank H.1
关键词diffusion pancreatic endocrine tumor pancreas pancreas MR pancreas neoplasms
刊名JOURNAL OF MAGNETIC RESONANCE IMAGING
2011-05-01
DOI10.1002/jmri.22541
33期:5页:1071-1079
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]NEUROENDOCRINE TUMORS ; BREATH-HOLD ; COEFFICIENT ; CELLULARITY ; SYSTEM ; CANCER ; GRADE ; CLASSIFICATION ; PROGNOSIS ; PROPOSAL
英文摘要

Purpose: To retrospectively assess apparent diffusion coefficients (ADCs) of different subtypes of pancreatic endocrine tumors based on the World Health Organization (WHO) classification system and analyze the potentially responsible histopathologic characteristics.

Materials and Methods: Following Institutional Review Board (IRB) approval, 18 patients with surgical pathology-proven pancreatic endocrine tumors were evaluated. Tumors were subcategorized based on the WHO grading classification into well-differentiated tumors with benign and uncertain behavior and endocrine carcinomas with well and poor differentiation. ADCs were measured on diffusion-weighted (DW) images and compared using Student′s t-test and one-way analysis of variance. The correlation between ADCs, tumor cellularity, Ki-67 labeling index (an index of cell growth), and extracellular fibrosis were analyzed.

Results: A difference was demonstrated in mean ADCs between well-differentiated endocrine tumors (1.75 +/- 0.53) and endocrine carcinomas (1.00 +/- 0.19 x 10(-3)mm(2)/sec) (P < 0.01). After excluding the three well-differentiated endocrine tumors with benign behavior and marked fibrosis, a significant inverse correlation between ADC values and cellularity of endocrine tumors was observed. An inverse correlation was seen between Ki-67 labeling index. and ADC values (r = -0.70; P < 0.01).

Conclusion: Tumor cellularity and/or extracellular fibrosis may account for various ADCs in pancreatic endocrine tumors. ADC correlates well with the Ki-67 labeling index and may help predict growth of endocrine tumors.

语种英语
WOS记录号WOS:000289999700008
引用统计
被引频次:67[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66744
专题北京大学第二临床医学院_放射科
作者单位1.Northwestern Univ, Body Imaging Sect, Feinberg Sch Med, Dept Radiol, Chicago, IL 60611 USA
2.Peking Univ, Dept Radiol, Peoples Hosp, Beijing 100871, Peoples R China
3.Northwestern Univ, Dept Pathol, Feinberg Sch Med, Chicago, IL 60611 USA
4.Northwestern Univ, Dept Anesthesiol, Feinberg Sch Med, Chicago, IL 60611 USA
推荐引用方式
GB/T 7714
Wang, Yi,Chen, Zongming E.,Yaghmai, Vahid,et al. Diffusion-Weighted MR Imaging in Pancreatic Endocrine Tumors Correlated With Histopathologic Characteristics[J]. JOURNAL OF MAGNETIC RESONANCE IMAGING,2011,33(5):1071-1079.
APA Wang, Yi.,Chen, Zongming E..,Yaghmai, Vahid.,Nikolaidis, Paul.,McCarthy, Robert J..,...&Miller, Frank H..(2011).Diffusion-Weighted MR Imaging in Pancreatic Endocrine Tumors Correlated With Histopathologic Characteristics.JOURNAL OF MAGNETIC RESONANCE IMAGING,33(5),1071-1079.
MLA Wang, Yi,et al."Diffusion-Weighted MR Imaging in Pancreatic Endocrine Tumors Correlated With Histopathologic Characteristics".JOURNAL OF MAGNETIC RESONANCE IMAGING 33.5(2011):1071-1079.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Yi]的文章
[Chen, Zongming E.]的文章
[Yaghmai, Vahid]的文章
百度学术
百度学术中相似的文章
[Wang, Yi]的文章
[Chen, Zongming E.]的文章
[Yaghmai, Vahid]的文章
必应学术
必应学术中相似的文章
[Wang, Yi]的文章
[Chen, Zongming E.]的文章
[Yaghmai, Vahid]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。