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学科主题临床医学
The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis
Wang, L.1,2,3; Zhang, L.1; Wang, Z. -F.2,4; Huang, Z. -X.1,2,3; Hu, X.1,2,3; Gong, L.1; Tang, X.1; Liu, F.1; Luo, Z.1; Ji, W.2; Hu, W. -F.2,3; Woodward, Z.2; Zhu, J.4; Liu, Y. -Z.1; Nguyen, Q. D.2; Li, D. W. -C.1,2,3
关键词alpha A-crystallin experimental autoimmune uveitis gene therapy uveitis
刊名CURRENT MOLECULAR MEDICINE
2015
DOI10.2174/1566524015666150731101146
15期:6页:558-564
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Medicine, Research & Experimental
研究领域[WOS]Research & Experimental Medicine
关键词[WOS]HEAT-SHOCK-PROTEIN ; MITOCHONDRIAL OXIDATIVE STRESS ; LENS EPITHELIAL-CELLS ; TOLL-LIKE RECEPTORS ; B-CRYSTALLIN ; TNF-ALPHA ; INDUCED APOPTOSIS ; RETINAL AUTOIMMUNITY ; MOLECULAR CHAPERONE ; PROTECTIVE ACTIVITY
英文摘要

Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, alpha A-crystallin has been found to be up-regulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of alpha A-crystallin and discuss its functional mechanisms in EAU.

语种英语
WOS记录号WOS:000359986900008
项目编号81272228 ; 8282012
资助机构National Science Foundation of China ; Research Prevent Blindness ; Lotus Scholar Program ; Zhongshan Ophthalmic Center ; Chinese Scholarship Council
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66745
专题北京大学第二临床医学院
作者单位1.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China
2.Univ Nebraska Med Ctr, Stanley M Truhlsen Eye Inst, Dept Ophthalmol & Visual Sci, Coll Med, Omaha, NE 68198 USA
3.Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Educ Minist China, Changsha 410081, Hunan, Peoples R China
4.Peking Univ, Hepatobiliary Surg Ctr, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China
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GB/T 7714
Wang, L.,Zhang, L.,Wang, Z. -F.,et al. The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis[J]. CURRENT MOLECULAR MEDICINE,2015,15(6):558-564.
APA Wang, L..,Zhang, L..,Wang, Z. -F..,Huang, Z. -X..,Hu, X..,...&Li, D. W. -C..(2015).The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis.CURRENT MOLECULAR MEDICINE,15(6),558-564.
MLA Wang, L.,et al."The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis".CURRENT MOLECULAR MEDICINE 15.6(2015):558-564.
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