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学科主题: 临床医学
题名:
The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis
作者: Wang, L.1,2,3; Zhang, L.1; Wang, Z. -F.2,4; Huang, Z. -X.1,2,3; Hu, X.1,2,3; Gong, L.1; Tang, X.1; Liu, F.1; Luo, Z.1; Ji, W.2; Hu, W. -F.2,3; Woodward, Z.2; Zhu, J.4; Liu, Y. -Z.1; Nguyen, Q. D.2; Li, D. W. -C.1,2,3
关键词: alpha A-crystallin ; experimental autoimmune uveitis ; gene therapy ; uveitis
刊名: CURRENT MOLECULAR MEDICINE
发表日期: 2015
DOI: 10.2174/1566524015666150731101146
卷: 15, 期:6, 页:558-564
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Medicine, Research & Experimental
研究领域[WOS]: Research & Experimental Medicine
关键词[WOS]: HEAT-SHOCK-PROTEIN ; MITOCHONDRIAL OXIDATIVE STRESS ; LENS EPITHELIAL-CELLS ; TOLL-LIKE RECEPTORS ; B-CRYSTALLIN ; TNF-ALPHA ; INDUCED APOPTOSIS ; RETINAL AUTOIMMUNITY ; MOLECULAR CHAPERONE ; PROTECTIVE ACTIVITY
英文摘要:

Uveitis refers to a group of ocular inflammatory diseases that can lead to blindness. For years, researchers have been trying to decipher the underlying mechanisms and develop therapeutic strategies using the model of experimental autoimmune uveitis (EAU). Recently, alpha A-crystallin has been found to be up-regulated in EAU and can even ameliorate its severity through different mechanisms, suggesting its use as a potent therapeutic factor against uveitis. Here we review the protective role of alpha A-crystallin and discuss its functional mechanisms in EAU.

语种: 英语
所属项目编号: 81272228 ; 8282012
项目资助者: National Science Foundation of China ; Research Prevent Blindness ; Lotus Scholar Program ; Zhongshan Ophthalmic Center ; Chinese Scholarship Council
WOS记录号: WOS:000359986900008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66745
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Sun Yat Sen Univ, State Key Lab Ophthalmol, Zhongshan Ophthalm Ctr, Guangzhou 510060, Guangdong, Peoples R China
2.Univ Nebraska Med Ctr, Stanley M Truhlsen Eye Inst, Dept Ophthalmol & Visual Sci, Coll Med, Omaha, NE 68198 USA
3.Hunan Normal Univ, Coll Life Sci, Key Lab Prot Chem & Dev Biol, Educ Minist China, Changsha 410081, Hunan, Peoples R China
4.Peking Univ, Hepatobiliary Surg Ctr, Peking Univ Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Wang, L.,Zhang, L.,Wang, Z. -F.,et al. The Role of alpha A-Crystallin in Experimental Autoimmune Uveitis[J]. CURRENT MOLECULAR MEDICINE,2015,15(6):558-564.
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